| # | Title | Journal | Year | Citations |
|---|
| 1 | Fiji: an open-source platform for biological-image analysis | Nature Methods | 2012 | 47,818 |
| 2 | On the nature of allosteric transitions: A plausible model | Journal of Molecular Biology | 1965 | 8,467 |
| 3 | Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein | Cell | 2020 | 6,979 |
| 4 | Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) | Science | 1983 | 6,401 |
| 5 | Genetic regulatory mechanisms in the synthesis of proteins | Journal of Molecular Biology | 1961 | 6,014 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 7 | Correspondence of the brain's functional architecture during activation and rest | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 4,636 |
| 8 | Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria | Microbiology (United Kingdom) | 1979 | 4,194 |
| 9 | Molecular characterization of mitochondrial apoptosis-inducing factor | Nature | 1999 | 3,697 |
| 10 | Life with 6000 Genes | Science | 1996 | 3,548 |
| 11 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | Nature | 2020 | 3,542 |
| 12 | The complete genome sequence of the Gram-positive bacterium Bacillus subtilis | Nature | 1997 | 3,519 |
| 13 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion | Cell | 2005 | 3,273 |
| 14 | Synaptic Pruning by Microglia Is Necessary for Normal Brain Development | Science | 2011 | 3,138 |
| 15 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 16 | Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines | Blood | 2008 | 2,887 |
| 17 | Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA | FEBS Journal | 1980 | 2,712 |
| 18 | A genome-wide association study identifies novel risk loci for type 2 diabetes | Nature | 2007 | 2,651 |
| 19 | Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis | Nature Genetics | 2006 | 2,584 |
| 20 | T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV | Nature | 1984 | 2,568 |
| 21 | TrackMate: An open and extensible platform for single-particle tracking | Methods | 2017 | 2,546 |
| 22 | Evolution and tinkering | Science | 1977 | 2,539 |
| 23 | Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota | Science | 2015 | 2,539 |
| 24 | Bacillus thuringiensis and Its Pesticidal Crystal Proteins | Microbiology and Molecular Biology Reviews | 1998 | 2,505 |
| 25 | Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease | Science | 2000 | 2,451 |
| 26 | Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients | Science | 2020 | 2,374 |
| 27 | Integration of biological networks and gene expression data using Cytoscape | Nature Protocols | 2007 | 2,275 |
| 28 | Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 2,195 |
| 29 | Animals in a bacterial world, a new imperative for the life sciences | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 2,181 |
| 30 | The effect of human mobility and control measures on the COVID-19 epidemic in China | Science | 2020 | 2,168 |
| 31 | Allosteric proteins and cellular control systems | Journal of Molecular Biology | 1963 | 2,093 |
| 32 | Innate lymphoid cells — a proposal for uniform nomenclature | Nature Reviews Immunology | 2013 | 2,054 |
| 33 | Aspergillus fumigatusand Aspergillosis | Clinical Microbiology Reviews | 1999 | 2,051 |
| 34 | The 1993–94 Généthon human genetic linkage map | Nature Genetics | 1994 | 2,015 |
| 35 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 36 | Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study | Lancet, The | 2016 | 1,913 |
| 37 | Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction | Nature | 1992 | 1,880 |
| 38 | The Genome Sequence of the Malaria MosquitoAnopheles gambiae | Science | 2002 | 1,859 |
| 39 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
| 40 | Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization | Nature | 2021 | 1,803 |
| 41 | A second-generation linkage map of the human genome | Nature | 1992 | 1,795 |
| 42 | Antigen — Antibody Reactions In Gels | Acta Pathologica Et Microbiologica Scandinavica | 1949 | 1,795 |
| 43 | The complete general secretory pathway in gram-negative bacteria | Microbiological Reviews | 1993 | 1,764 |
| 44 | Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science | 2020 | 1,749 |
| 45 | The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1 | Nature | 1996 | 1,662 |
| 46 | Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior | Science | 2007 | 1,637 |
| 47 | A molecular marker of artemisinin-resistant Plasmodium falciparum malaria | Nature | 2014 | 1,617 |
| 48 | Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors | Nature Medicine | 2009 | 1,614 |
| 49 | Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism | Nature Genetics | 2003 | 1,612 |
| 50 | Massive gene decay in the leprosy bacillus | Nature | 2001 | 1,607 |
