| # | Title | Journal | Year | Citations |
|---|
| 1 | The Cochrane Collaboration's tool for assessing risk of bias in randomised trials | BMJ: British Medical Journal | 2011 | 23,287 |
| 2 | Statistical analysis of cointegration vectors | Journal of Economic Dynamics and Control | 1988 | 13,109 |
| 3 | STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets | Nucleic Acids Research | 2019 | 12,237 |
| 4 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 5 | A human gut microbial gene catalogue established by metagenomic sequencing | Nature | 2010 | 9,342 |
| 6 | STRING v10: protein–protein interaction networks, integrated over the tree of life | Nucleic Acids Research | 2015 | 9,029 |
| 7 | MAXIMUM LIKELIHOOD ESTIMATION AND INFERENCE ON COINTEGRATION — WITH APPLICATIONS TO THE DEMAND FOR MONEY | Oxford Bulletin of Economics and Statistics | 1990 | 8,592 |
| 8 | Planetary boundaries: Guiding human development on a changing planet | Science | 2015 | 7,124 |
| 9 | New method for quantitative determination of uronic acids | Analytical Biochemistry | 1973 | 6,487 |
| 10 | The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible | Nucleic Acids Research | 2017 | 6,303 |
| 11 | Enterotypes of the human gut microbiome | Nature | 2011 | 5,800 |
| 12 | Stable isotopes in precipitation | Tellus | 2022 | 5,642 |
| 13 | A metagenome-wide association study of gut microbiota in type 2 diabetes | Nature | 2012 | 5,345 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 15 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 16 | Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer | New England Journal of Medicine | 2005 | 4,601 |
| 17 | SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials | Annals of Internal Medicine | 2013 | 4,463 |
| 18 | The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets | Nucleic Acids Research | 2021 | 4,274 |
| 19 | Sample Size in Qualitative Interview Studies | Qualitative Health Research | 2016 | 4,227 |
| 20 | Stable isotopes in precipitation | Tellus | 1964 | 4,147 |
| 21 | Evidence for general instability of past climate from a 250-kyr ice-core record | Nature | 1993 | 4,111 |
| 22 | Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction | New England Journal of Medicine | 2019 | 4,108 |
| 23 | From game design elements to gamefulness | | 2011 | 4,081 |
| 24 | Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes | New England Journal of Medicine | 2003 | 3,894 |
| 25 | Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions | Science | 2009 | 3,883 |
| 26 | Planetary Boundaries: Exploring the Safe Operating Space for Humanity | Ecology and Society | 2009 | 3,867 |
| 27 | Standardised Nordic questionnaires for the analysis of musculoskeletal symptoms | Applied Ergonomics | 1987 | 3,769 |
| 28 | Richness of human gut microbiome correlates with metabolic markers | Nature | 2013 | 3,641 |
| 29 | Assessing the Performance of Prediction Models | Epidemiology | 2010 | 3,387 |
| 30 | SignalP 5.0 improves signal peptide predictions using deep neural networks | Nature Biotechnology | 2019 | 3,317 |
| 31 | Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill | Journal of Immunological Methods | 1989 | 3,265 |
| 32 | The Danish National Patient Register | Scandinavian Journal of Public Health | 2011 | 3,237 |
| 33 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 34 | PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions | Journal of Chemical Theory and Computation | 2011 | 3,121 |
| 35 | The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored | Nucleic Acids Research | 2011 | 3,014 |
| 36 | The size and burden of mental disorders and other disorders of the brain in Europe 2010 | European Neuropsychopharmacology | 2011 | 2,930 |
| 37 | Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis | Journal of Neurochemistry | 1984 | 2,872 |
| 38 | Antibiotic resistance of bacterial biofilms | International Journal of Antimicrobial Agents | 2010 | 2,809 |
| 39 | Assembly, configuration, and break-up history of Rodinia: A synthesis | Precambrian Research | 2008 | 2,747 |
| 40 | The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection | Annals of the Rheumatic Diseases | 2009 | 2,713 |
| 41 | Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 | Journal of the American College of Cardiology | 2017 | 2,705 |
| 42 | Iolite: Freeware for the visualisation and processing of mass spectrometric data | Journal of Analytical Atomic Spectrometry | 2011 | 2,629 |
| 43 | eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses | Nucleic Acids Research | 2019 | 2,575 |
| 44 | Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations | Journal of Pain | 2008 | 2,564 |
| 45 | The Physiology of Glucagon-like Peptide 1 | Physiological Reviews | 2007 | 2,504 |
| 46 | DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Nature | 2005 | 2,491 |
| 47 | High-resolution record of Northern Hemisphere climate extending into the last interglacial period | Nature | 2004 | 2,489 |
| 48 | The Microbial Engines That Drive Earth's Biogeochemical Cycles | Science | 2008 | 2,449 |
| 49 | Cross-Validation of Item Selection and Scoring for the SF-12 Health Survey in Nine Countries | Journal of Clinical Epidemiology | 1998 | 2,428 |
| 50 | Global Iron Connections Between Desert Dust, Ocean Biogeochemistry, and Climate | Science | 2005 | 2,365 |
