| # | Title | Journal | Year | Citations |
|---|
| 1 | Bioconductor: open software development for computational biology and bioinformatics | Genome Biology | 2004 | 10,796 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) | Journal of Thrombosis and Haemostasis | 2006 | 6,039 |
| 4 | The chemokine system in diverse forms of macrophage activation and polarization | Trends in Immunology | 2004 | 5,272 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes | Trends in Immunology | 2002 | 4,494 |
| 7 | Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 | Journal of the American College of Cardiology | 2020 | 4,468 |
| 8 | Advanced capabilities for materials modelling with Quantum ESPRESSO | Journal of Physics Condensed Matter | 2017 | 4,303 |
| 9 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 10 | Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer | New England Journal of Medicine | 2002 | 3,765 |
| 11 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 12 | Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy | Cellular Physiology and Biochemistry | 2017 | 3,443 |
| 13 | Finite-time Analysis of the Multiarmed Bandit Problem | Machine Learning | 2002 | 3,350 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 15 | Genomic Classification and Prognosis in Acute Myeloid Leukemia | New England Journal of Medicine | 2016 | 3,067 |
| 16 | Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension | Lancet, The | 1997 | 2,841 |
| 17 | Classification criteria for psoriatic arthritis: Development of new criteria from a large international study | Arthritis and Rheumatism | 2006 | 2,811 |
| 18 | The Twentieth Century Reanalysis Project | Quarterly Journal of the Royal Meteorological Society | 2011 | 2,785 |
| 19 | Incidence, Predictors, and Outcome of Thrombosis After Successful Implantation of Drug-Eluting Stents | JAMA - Journal of the American Medical Association | 2005 | 2,769 |
| 20 | ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) | European Heart Journal | 2011 | 2,767 |
| 21 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 22 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 23 | Expanding consensus in portal hypertension | Journal of Hepatology | 2015 | 2,604 |
| 24 | Transcranial direct current stimulation: State of the art 2008 | Brain Stimulation | 2008 | 2,538 |
| 25 | Causal Inference without Balance Checking: Coarsened Exact Matching | Political Analysis | 2012 | 2,218 |
| 26 | Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Nature Genetics | 2009 | 2,155 |
| 27 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society | European Heart Journal | 2013 | 2,132 |
| 28 | The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 | Annals of Oncology | 2015 | 2,122 |
| 29 | The global spectrum of plant form and function | Nature | 2016 | 2,022 |
| 30 | Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation | Circulation: Arrhythmia and Electrophysiology | 2010 | 1,962 |
| 31 | A Gene Network Regulating Lysosomal Biogenesis and Function | Science | 2009 | 1,958 |
| 32 | Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes | Nature Medicine | 1998 | 1,908 |
| 33 | The genome of the domesticated apple (Malus × domestica Borkh.) | Nature Genetics | 2010 | 1,891 |
| 34 | Protein carbonyl groups as biomarkers of oxidative stress | Clinica Chimica Acta | 2003 | 1,888 |
| 35 | Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: A multiple-center epidemiological study* | Critical Care Medicine | 2005 | 1,885 |
| 36 | Decontamination of wastewaters containing synthetic organic dyes by electrochemical methods: A general review | Applied Catalysis B: Environmental | 2009 | 1,863 |
| 37 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update | Annals of the Rheumatic Diseases | 2020 | 1,860 |
| 38 | ESPEN guidelines on nutrition in cancer patients | Clinical Nutrition | 2017 | 1,855 |
| 39 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 40 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 41 | Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy | JAMA - Journal of the American Medical Association | 2020 | 1,777 |
| 42 | Moderate and severe traumatic brain injury in adults | Lancet Neurology, The | 2008 | 1,715 |
| 43 | GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours | Nature | 1989 | 1,680 |
| 44 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Heart Rhythm | 2017 | 1,671 |
| 45 | Smoldering and polarized inflammation in the initiation and promotion of malignant disease | Cancer Cell | 2005 | 1,622 |
| 46 | Epidemiology and Risk Factors of Urothelial Bladder Cancer | European Urology | 2013 | 1,572 |
| 47 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 48 | ISTH interim guidance on recognition and management of coagulopathy in COVID‐19 | Journal of Thrombosis and Haemostasis | 2020 | 1,513 |
| 49 | BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update | Journal of Hepatology | 2022 | 1,495 |
| 50 | Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer | Lancet, The | 1997 | 1,479 |
