| # | Title | Journal | Year | Citations |
|---|
| 1 | Meta-analysis in clinical trials | Contemporary Clinical Trials | 1986 | 33,020 |
| 2 | A new and rapid colorimetric determination of acetylcholinesterase activity | Biochemical Pharmacology | 1961 | 23,305 |
| 3 | Assessing the quality of reports of randomized clinical trials: Is blinding necessary? | Contemporary Clinical Trials | 1996 | 16,054 |
| 4 | A logical calculus of the ideas immanent in nervous activity | The Bulletin of Mathematical Biophysics | 1943 | 12,960 |
| 5 | Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction | Biochemical Pharmacology | 1973 | 12,583 |
| 6 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1 | Advanced Drug Delivery Reviews | 2001 | 11,703 |
| 7 | Nitric oxide: physiology, pathophysiology, and pharmacology | Pharmacological Reviews | 1991 | 11,205 |
| 8 | Apoptosis: A Review of Programmed Cell Death | Toxicologic Pathology | 2007 | 10,063 |
| 9 | A method for estimating the probability of adverse drug reactions | Clinical Pharmacology and Therapeutics | 1981 | 9,758 |
| 10 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings | Advanced Drug Delivery Reviews | 1997 | 8,880 |
| 11 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy | Journal of Medicinal Chemistry | 2004 | 7,428 |
| 12 | Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test | Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology | 1975 | 6,858 |
| 13 | Ethical guidelines for investigations of experimental pain in conscious animals | Pain | 1983 | 6,843 |
| 14 | Revised methods for the Salmonella mutagenicity test | Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology | 1983 | 6,361 |
| 15 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays | Journal of Biomolecular Screening | 1999 | 6,128 |
| 16 | Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review | Journal of Controlled Release | 2000 | 5,797 |
| 17 | The McGill Pain Questionnaire: Major properties and scoring methods | Pain | 1975 | 5,648 |
| 18 | Molecular Properties That Influence the Oral Bioavailability of Drug Candidates | Journal of Medicinal Chemistry | 2002 | 5,626 |
| 19 | Biological effects of essential oils – A review | Food and Chemical Toxicology | 2008 | 5,516 |
| 20 | Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework | Clinical Pharmacology and Therapeutics | 2001 | 5,390 |
| 21 | Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes | Journal of Medicinal Chemistry | 2006 | 5,196 |
| 22 | Free radicals, metals and antioxidants in oxidative stress-induced cancer | Chemico-Biological Interactions | 2006 | 5,051 |
| 23 | Practical methods for incorporating summary time-to-event data into meta-analysis | Trials | 2007 | 4,941 |
| 24 | Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin | Skin Pharmacology and Physiology | 2016 | 4,815 |
| 25 | A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines | Tetrahedron Letters | 1975 | 4,764 |
| 26 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man | Pain | 1988 | 4,621 |
| 27 | A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia | Pain | 1988 | 4,531 |
| 28 | Identification of acquired antimicrobial resistance genes | Journal of Antimicrobial Chemotherapy | 2012 | 4,515 |
| 29 | Natural Products as Sources of New Drugs from 1981 to 2014 | Journal of Natural Products | 2016 | 4,486 |
| 30 | Fast and Easy Multiresidue Method Employing Acetonitrile Extraction/Partitioning and “Dispersive Solid-Phase Extraction” for the Determination of Pesticide Residues in Produce | Journal of AOAC INTERNATIONAL | 2003 | 4,413 |
| 31 | Recent advances with liposomes as pharmaceutical carriers | Nature Reviews Drug Discovery | 2005 | 4,338 |
| 32 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Nature Reviews Drug Discovery | 2009 | 4,327 |
| 33 | A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability | Pharmaceutical Research | 1995 | 4,287 |
| 34 | Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale | Pain | 2001 | 4,278 |
| 35 | Neurocircuitry of Addiction | Neuropsychopharmacology | 2010 | 4,187 |
| 36 | Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies | Pharmacological Reviews | 2006 | 4,172 |
| 37 | Bioavailability of Curcumin: Problems and Promises | Molecular Pharmaceutics | 2007 | 4,138 |
| 38 | A simplified method of evaluating dose-effect experiments | Journal of Pharmacology and Experimental Therapeutics | 1949 | 4,135 |
| 39 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges | International Journal of Antimicrobial Agents | 2020 | 4,124 |
| 40 | Modeling and comparison of dissolution profiles | European Journal of Pharmaceutical Sciences | 2001 | 4,119 |
| 41 | Application of the pople-santry-segal CNDO method to the cyclopropylcarbinyl and cyclobutyl cation and to bicyclobutane | Tetrahedron | 1968 | 4,057 |
| 42 | Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals | Journal of Medicinal Chemistry | 2014 | 3,996 |
| 43 | Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments | Journal of Computer-Aided Molecular Design | 2013 | 3,989 |
| 44 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening | Journal of Medicinal Chemistry | 2004 | 3,982 |
| 45 | Measurement of health status | Contemporary Clinical Trials | 1989 | 3,981 |
| 46 | Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 | Journal of Natural Products | 2012 | 3,976 |
| 47 | Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial | International Journal of Antimicrobial Agents | 2020 | 3,955 |
| 48 | Antimicrobial effects of silver nanoparticles | Nanomedicine: Nanotechnology, Biology, and Medicine | 2007 | 3,939 |
| 49 | Metals, Toxicity and Oxidative Stress | Current Medicinal Chemistry | 2005 | 3,932 |
| 50 | Natural Products as Sources of New Drugs over the Last 25 Years⊥ | Journal of Natural Products | 2007 | 3,838 |
| 51 | Digitoxin metabolism by rat liver microsomes | Biochemical Pharmacology | 1975 | 3,820 |
| 52 | Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices | Journal of Pharmaceutical Sciences | 1963 | 3,810 |
| 53 | Mechanisms of solute release from porous hydrophilic polymers | International Journal of Pharmaceutics | 1983 | 3,799 |
| 54 | Flavonoids as Antioxidants | Journal of Natural Products | 2000 | 3,737 |
| 55 | Lead- and drug-like compounds: the rule-of-five revolution | Drug Discovery Today: Technologies | 2004 | 3,723 |
| 56 | Nanoparticle therapeutics: an emerging treatment modality for cancer | Nature Reviews Drug Discovery | 2008 | 3,710 |
| 57 | Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges | Tetrahedron | 1980 | 3,706 |
| 58 | Fish bioaccumulation and biomarkers in environmental risk assessment: a review | Environmental Toxicology and Pharmacology | 2003 | 3,693 |
| 59 | Toxicity, mechanism and health effects of some heavy metals | Interdisciplinary Toxicology | 2014 | 3,692 |
| 60 | Nano based drug delivery systems: recent developments and future prospects | Journal of Nanobiotechnology | 2018 | 3,689 |
| 61 | Methods for in vitro evaluating antimicrobial activity: A review | Journal of Pharmaceutical Analysis | 2016 | 3,675 |
| 62 | Cisplatin in cancer therapy: Molecular mechanisms of action | European Journal of Pharmacology | 2014 | 3,667 |
| 63 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art | Pain | 2000 | 3,615 |
| 64 | Liposomal drug delivery systems: From concept to clinical applications | Advanced Drug Delivery Reviews | 2013 | 3,565 |
| 65 | In Silico Detection and Typing of Plasmids using PlasmidFinder and Plasmid Multilocus Sequence Typing | Antimicrobial Agents and Chemotherapy | 2014 | 3,558 |
| 66 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases | Nature Reviews Drug Discovery | 2017 | 3,558 |
| 67 | The short-form McGill pain questionnaire | Pain | 1987 | 3,518 |
| 68 | Can the pharmaceutical industry reduce attrition rates? | Nature Reviews Drug Discovery | 2004 | 3,510 |
| 69 | Hydrogels for biomedical applications | Advanced Drug Delivery Reviews | 2002 | 3,447 |
| 70 | 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data | Xenobiotica | 1999 | 3,429 |
| 71 | The importance of the ratio of omega-6/omega-3 essential fatty acids | Biomedicine and Pharmacotherapy | 2002 | 3,394 |
| 72 | Doxil® — The first FDA-approved nano-drug: Lessons learned | Journal of Controlled Release | 2012 | 3,356 |
| 73 | Free radicals, antioxidants and functional foods: Impact on human health | Pharmacognosy Reviews | 2010 | 3,350 |
| 74 | Hydrogels in pharmaceutical formulations | European Journal of Pharmaceutics and Biopharmaceutics | 2000 | 3,290 |
| 75 | Therapeutic potential of resveratrol: the in vivo evidence | Nature Reviews Drug Discovery | 2006 | 3,283 |
| 76 | Optimal two-stage designs for phase II clinical trials | Contemporary Clinical Trials | 1989 | 3,264 |
| 77 | Role of Nrf2 in Oxidative Stress and Toxicity | Annual Review of Pharmacology and Toxicology | 2013 | 3,261 |
| 78 | A simple equation for description of solute release II. Fickian and anomalous release from swellable devices | Journal of Controlled Release | 1987 | 3,239 |
| 79 | The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants | Journal of Exposure Science and Environmental Epidemiology | 2001 | 3,194 |
| 80 | Cellular processing of platinum anticancer drugs | Nature Reviews Drug Discovery | 2005 | 3,194 |
| 81 | Receptors for purines and pyrimidines | Pharmacological Reviews | 1998 | 3,194 |
| 82 | Central sensitization: Implications for the diagnosis and treatment of pain | Pain | 2011 | 3,166 |
| 83 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 | Journal of Natural Products | 2020 | 3,162 |
| 84 | Engineering precision nanoparticles for drug delivery | Nature Reviews Drug Discovery | 2021 | 3,154 |
| 85 | Animal research: Reporting in vivo experiments: The ARRIVE guidelines | British Journal of Pharmacology | 2010 | 3,150 |
| 86 | Human health effects of air pollution | Environmental Pollution | 2008 | 3,146 |
| 87 | The enduring effects of abuse and related adverse experiences in childhood | European Archives of Psychiatry and Clinical Neuroscience | 2006 | 3,143 |
| 88 | Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents | Planta Medica | 1982 | 3,136 |
| 89 | Strategies in the design of nanoparticles for therapeutic applications | Nature Reviews Drug Discovery | 2010 | 3,124 |
| 90 | Environment-sensitive hydrogels for drug delivery | Advanced Drug Delivery Reviews | 2001 | 3,118 |
| 91 | The glutamate receptor ion channels | Pharmacological Reviews | 1999 | 3,111 |
| 92 | Block copolymer micelles for drug delivery: design, characterization and biological significance | Advanced Drug Delivery Reviews | 2001 | 3,107 |
| 93 | GLUTATHIONE TRANSFERASES | Annual Review of Pharmacology and Toxicology | 2005 | 3,104 |
| 94 | Targeting multidrug resistance in cancer | Nature Reviews Drug Discovery | 2006 | 3,098 |
| 95 | Solid lipid nanoparticles (SLN) for controlled drug delivery â a review of the state of the art | European Journal of Pharmaceutics and Biopharmaceutics | 2000 | 3,078 |
| 96 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles | International Journal of Pharmaceutics | 2006 | 3,077 |
| 97 | Determination of minimum inhibitory concentrations | Journal of Antimicrobial Chemotherapy | 2001 | 3,076 |
| 98 | How many drug targets are there? | Nature Reviews Drug Discovery | 2006 | 3,073 |
| 99 | The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds | Toxicological Sciences | 2006 | 3,071 |
| 100 | A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs | Journal of Controlled Release | 1987 | 3,070 |
