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1Meta-analysis in clinical trialsContemporary Clinical Trials198633,020
2A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology196123,305
3Assessing the quality of reports of randomized clinical trials: Is blinding necessary?Contemporary Clinical Trials199616,054
4A logical calculus of the ideas immanent in nervous activityThe Bulletin of Mathematical Biophysics194312,960
5Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology197312,583
6Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1Advanced Drug Delivery Reviews200111,703
7Nitric oxide: physiology, pathophysiology, and pharmacologyPharmacological Reviews199111,205
8Apoptosis: A Review of Programmed Cell DeathToxicologic Pathology200710,063
9A method for estimating the probability of adverse drug reactionsClinical Pharmacology and Therapeutics19819,758
10Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews19978,880
11Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking AccuracyJournal of Medicinal Chemistry20047,428
12Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research - Environmental Mutagenesis and Related Subjects Including Methodology19756,858
13Ethical guidelines for investigations of experimental pain in conscious animalsPain19836,843
14Revised methods for the Salmonella mutagenicity testMutation Research - Environmental Mutagenesis and Related Subjects Including Methodology19836,361
15A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysJournal of Biomolecular Screening19996,128
16Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a reviewJournal of Controlled Release20005,797
17The McGill Pain Questionnaire: Major properties and scoring methodsPain19755,648
18Molecular Properties That Influence the Oral Bioavailability of Drug CandidatesJournal of Medicinal Chemistry20025,626
19Biological effects of essential oils – A reviewFood and Chemical Toxicology20085,516
20Biomarkers and surrogate endpoints: Preferred definitions and conceptual frameworkClinical Pharmacology and Therapeutics20015,390
21Extra Precision Glide:  Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand ComplexesJournal of Medicinal Chemistry20065,196
22Free radicals, metals and antioxidants in oxidative stress-induced cancerChemico-Biological Interactions20065,051
23Practical methods for incorporating summary time-to-event data into meta-analysisTrials20074,941
24Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in SkinSkin Pharmacology and Physiology20164,815
25A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridinesTetrahedron Letters19754,764
26A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in manPain19884,621
27A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaPain19884,531
28Identification of acquired antimicrobial resistance genesJournal of Antimicrobial Chemotherapy20124,515
29Natural Products as Sources of New Drugs from 1981 to 2014Journal of Natural Products20164,486
30Fast and Easy Multiresidue Method Employing Acetonitrile Extraction/Partitioning and “Dispersive Solid-Phase Extraction” for the Determination of Pesticide Residues in ProduceJournal of AOAC INTERNATIONAL20034,413
31Recent advances with liposomes as pharmaceutical carriersNature Reviews Drug Discovery20054,338
32Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Nature Reviews Drug Discovery20094,327
33A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailabilityPharmaceutical Research19954,287
34Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scalePain20014,278
35Neurocircuitry of AddictionNeuropsychopharmacology20104,187
36Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination StudiesPharmacological Reviews20064,172
37Bioavailability of Curcumin: Problems and PromisesMolecular Pharmaceutics20074,138
38A simplified method of evaluating dose-effect experimentsJournal of Pharmacology and Experimental Therapeutics19494,135
39Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challengesInternational Journal of Antimicrobial Agents20204,124
40Modeling and comparison of dissolution profilesEuropean Journal of Pharmaceutical Sciences20014,119
41Application of the pople-santry-segal CNDO method to the cyclopropylcarbinyl and cyclobutyl cation and to bicyclobutaneTetrahedron19684,057
42Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved PharmaceuticalsJournal of Medicinal Chemistry20143,996
43Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichmentsJournal of Computer-Aided Molecular Design20133,989
44Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database ScreeningJournal of Medicinal Chemistry20043,982
45Measurement of health statusContemporary Clinical Trials19893,981
46Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010Journal of Natural Products20123,976
47Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trialInternational Journal of Antimicrobial Agents20203,955
48Antimicrobial effects of silver nanoparticlesNanomedicine: Nanotechnology, Biology, and Medicine20073,939
49Metals, Toxicity and Oxidative StressCurrent Medicinal Chemistry20053,932
50Natural Products as Sources of New Drugs over the Last 25 YearsJournal of Natural Products20073,838
51Digitoxin metabolism by rat liver microsomesBiochemical Pharmacology19753,820
52Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matricesJournal of Pharmaceutical Sciences19633,810
53Mechanisms of solute release from porous hydrophilic polymersInternational Journal of Pharmaceutics19833,799
54Flavonoids as AntioxidantsJournal of Natural Products20003,737
55Lead- and drug-like compounds: the rule-of-five revolutionDrug Discovery Today: Technologies20043,723
56Nanoparticle therapeutics: an emerging treatment modality for cancerNature Reviews Drug Discovery20083,710
57Iterative partial equalization of orbital electronegativity—a rapid access to atomic chargesTetrahedron19803,706
58Fish bioaccumulation and biomarkers in environmental risk assessment: a reviewEnvironmental Toxicology and Pharmacology20033,693
59Toxicity, mechanism and health effects of some heavy metalsInterdisciplinary Toxicology20143,692
60Nano based drug delivery systems: recent developments and future prospectsJournal of Nanobiotechnology20183,689
61Methods for in vitro evaluating antimicrobial activity: A reviewJournal of Pharmaceutical Analysis20163,675
62Cisplatin in cancer therapy: Molecular mechanisms of actionEuropean Journal of Pharmacology20143,667
63Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the artPain20003,615
64Liposomal drug delivery systems: From concept to clinical applicationsAdvanced Drug Delivery Reviews20133,565
65In Silico Detection and Typing of Plasmids using PlasmidFinder and Plasmid Multilocus Sequence TypingAntimicrobial Agents and Chemotherapy20143,558
66MicroRNA therapeutics: towards a new era for the management of cancer and other diseasesNature Reviews Drug Discovery20173,558
67The short-form McGill pain questionnairePain19873,518
68Can the pharmaceutical industry reduce attrition rates?Nature Reviews Drug Discovery20043,510
69Hydrogels for biomedical applicationsAdvanced Drug Delivery Reviews20023,447
70'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic dataXenobiotica19993,429
71The importance of the ratio of omega-6/omega-3 essential fatty acidsBiomedicine and Pharmacotherapy20023,394
72Doxil® — The first FDA-approved nano-drug: Lessons learnedJournal of Controlled Release20123,356
73Free radicals, antioxidants and functional foods: Impact on human healthPharmacognosy Reviews20103,350
74Hydrogels in pharmaceutical formulationsEuropean Journal of Pharmaceutics and Biopharmaceutics20003,290
75Therapeutic potential of resveratrol: the in vivo evidenceNature Reviews Drug Discovery20063,283
76Optimal two-stage designs for phase II clinical trialsContemporary Clinical Trials19893,264
77Role of Nrf2 in Oxidative Stress and ToxicityAnnual Review of Pharmacology and Toxicology20133,261
78A simple equation for description of solute release II. Fickian and anomalous release from swellable devicesJournal of Controlled Release19873,239
79The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutantsJournal of Exposure Science and Environmental Epidemiology20013,194
80Cellular processing of platinum anticancer drugsNature Reviews Drug Discovery20053,194
81Receptors for purines and pyrimidinesPharmacological Reviews19983,194
82Central sensitization: Implications for the diagnosis and treatment of painPain20113,166
83Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019Journal of Natural Products20203,162
84Engineering precision nanoparticles for drug deliveryNature Reviews Drug Discovery20213,154
85Animal research: Reporting in vivo experiments: The ARRIVE guidelinesBritish Journal of Pharmacology20103,150
86Human health effects of air pollutionEnvironmental Pollution20083,146
87The enduring effects of abuse and related adverse experiences in childhoodEuropean Archives of Psychiatry and Clinical Neuroscience20063,143
88Brine Shrimp: A Convenient General Bioassay for Active Plant ConstituentsPlanta Medica19823,136
89Strategies in the design of nanoparticles for therapeutic applicationsNature Reviews Drug Discovery20103,124
90Environment-sensitive hydrogels for drug deliveryAdvanced Drug Delivery Reviews20013,118
91The glutamate receptor ion channelsPharmacological Reviews19993,111
92Block copolymer micelles for drug delivery: design, characterization and biological significanceAdvanced Drug Delivery Reviews20013,107
93GLUTATHIONE TRANSFERASESAnnual Review of Pharmacology and Toxicology20053,104
94Targeting multidrug resistance in cancerNature Reviews Drug Discovery20063,098
95Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the artEuropean Journal of Pharmaceutics and Biopharmaceutics20003,078
96Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticlesInternational Journal of Pharmaceutics20063,077
97Determination of minimum inhibitory concentrationsJournal of Antimicrobial Chemotherapy20013,076
98How many drug targets are there?Nature Reviews Drug Discovery20063,073
99The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like CompoundsToxicological Sciences20063,071
100A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discsJournal of Controlled Release19873,070