| CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice | Nucleic Acids Research | 1994 | 52.6K |
| Deep learning | Nature | 2015 | 31.1K |
| Optimization by simulated annealing | Science | 1983 | 26.9K |
| Differential Evolution – A Simple and Efficient Heuristic for global Optimization over Continuous Spaces | | 1997 | 14.3K |
| A New Approach to Linear Filtering and Prediction Problems | Journal of Basic Engineering | 1960 | 14K |
| Hierarchical Grouping to Optimize an Objective Function | Journal of the American Statistical Association | 1963 | 10.7K |
| Stochastic relaxation, gibbs distributions, and the bayesian restoration of images | IEEE Transactions on Pattern Analysis and Machine Intelligence | 1984 | 9.6K |
| A Tutorial on Support Vector Machines for Pattern Recognition | | 1998 | 9K |
| Primer3 on the WWW for general users and for biologist programmers | Methods in Molecular Biology | 2000 | 8.6K |
| A Decision-Theoretic Generalization of On-Line Learning and an Application to Boosting | Journal of Computer and System Sciences | 1997 | 8K |
| Greedy function approximation: A gradient boosting machine. | Annals of Statistics | 2001 | 7.8K |
| Learning the parts of objects by non-negative matrix factorization | Nature | 1999 | 7.4K |
| Unified segmentation | NeuroImage | 2005 | 5.6K |
| A Fast Iterative Shrinkage-Thresholding Algorithm for Linear Inverse Problems | SIAM Journal on Imaging Sciences | 2009 | 5.5K |
| A tutorial on support vector regression | Statistics and Computing | 2004 | 5.4K |
| A fast diffeomorphic image registration algorithm | NeuroImage | 2007 | 5.3K |
| Image-to-Image Translation with Conditional Adversarial Networks | | 2017 | 4.9K |
| Data clustering: 50 years beyond K-means | Pattern Recognition Letters | 2010 | 4.8K |
| Tensor Decompositions and Applications | SIAM Review | 2009 | 4.7K |
| A survey on deep learning in medical image analysis | Medical Image Analysis | 2017 | 4.7K |
| A tutorial on spectral clustering | Statistics and Computing | 2007 | 4.7K |
| MOEA/D: A Multiobjective Evolutionary Algorithm Based on Decomposition | IEEE Transactions on Evolutionary Computation | 2007 | 4.6K |
| On the implementation of an interior-point filter line-search algorithm for large-scale nonlinear programming | Mathematical Programming | 2006 | 4.4K |
| Training feedforward networks with the Marquardt algorithm | IEEE Transactions on Neural Networks | 1994 | 4.3K |
