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Top Articles

#TitleJournalYearCitations
1T-cell activation by transitory neo-antigens derived from distinct microbial pathwaysNature2014731
2Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cellsJournal of Experimental Medicine2013516
3Natural product and natural product derived drugs in clinical trialsNatural Product Reports2014471
4Antibiotics in the clinical pipeline in 2013Journal of Antibiotics2013348
5Constraining Cyclic Peptides To Mimic Protein Structure MotifsAngewandte Chemie - International Edition2014338
6Role for NLRP3 Inflammasome–mediated, IL-1β–Dependent Responses in Severe, Steroid-Resistant AsthmaAmerican Journal of Respiratory and Critical Care Medicine2017304
7Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and AutoregulationCell Host and Microbe2011301
8ConoServer: updated content, knowledge, and discovery tools in the conopeptide databaseNucleic Acids Research2012298
9Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principlesMolecular Neurodegeneration2019262
10Recognition of vitamin B metabolites by mucosal-associated invariant T cellsNature Communications2013261
11A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cellsJournal of Experimental Medicine2014245
12Antibiotics in the clinical pipeline in 2011Journal of Antibiotics2011236
13Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signalsMucosal Immunology2017216
14Conopeptide characterization and classifications: An analysis using ConoServerToxicon2010198
15Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-MycMolecular Cancer2021191
16Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidaseNature Communications2015186
17MAIT cells protect against pulmonary Legionella longbeachae infectionNature Communications2018177
18Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertensionCardiovascular Research2019165
19Discovery of a selective Na V 1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain modelsProceedings of the National Academy of Sciences of the United States of America2013164
20Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potencyProceedings of the National Academy of Sciences of the United States of America2010162
21Comparative α‐Helicity of Cyclic Pentapeptides in WaterAngewandte Chemie - International Edition2014153
22Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic NicheCancer Research2014151
23Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approachesAdvanced Drug Delivery Reviews2020150
24Targeting virulence not viability in the search for future antibacterialsBritish Journal of Clinical Pharmacology2015144
25Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in miceBritish Journal of Pharmacology2016143
26Bioactive cystine knot proteinsCurrent Opinion in Chemical Biology2011142
27Recent advances in microtubule-stabilizing agentsEuropean Journal of Medicinal Chemistry2018133
28The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1Nature Immunology2016127
29Inflammasomes in the lungMolecular Immunology2017126
30Solving the α-Conotoxin Folding Problem: Efficient Selenium-Directed On-Resin Generation of More Potent and Stable Nicotinic Acetylcholine Receptor AntagonistsJournal of the American Chemical Society2010124
31Improving on Nature: Making a Cyclic Heptapeptide Orally BioavailableAngewandte Chemie - International Edition2014123
32Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T CellsJournal of Biological Chemistry2015123
33Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin MetabolitesJournal of Immunology2015121
34Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cellsNature Communications2017113
35Inflammasomes in COPD and neutrophilic asthmaThorax2015109
36Catalyst‐Free N‐Arylation Using Unactivated FluorobenzenesAngewandte Chemie - International Edition2012105
37Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formationProceedings of the National Academy of Sciences of the United States of America2011101
38MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1Cancer Discovery2020101
39Clawing through Evolution: Toxin Diversification and Convergence in the Ancient Lineage Chilopoda (Centipedes)Molecular Biology and Evolution2014100
40Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)Current Topics in Medicinal Chemistry201296
41Novel Agonists and Antagonists for Human Protease Activated Receptor 2Journal of Medicinal Chemistry201091
42Invited reviewnative chemical ligation applied to the synthesis and bioengineering of circular peptides and proteinsBiopolymers201090
43Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras ProteinsJournal of Biological Chemistry201289
44Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworksProceedings of the National Academy of Sciences of the United States of America201585
45Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine ReceptorJournal of Medicinal Chemistry201384
46Circular proteins and mechanisms of cyclizationBiopolymers201079
47Blockade of Neuronal α7-nAChR by α-Conotoxin ImI Explained by Computational Scanning and Energy CalculationsPLoS Computational Biology201177
48α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABABreceptorsGut201777
49Extracting value: mechanistic insights into the formation of natural product artifacts – case studies in marine natural productsNatural Product Reports202076
50IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infectionScience Immunology201975