| # | Title | Journal | Year | Citations |
|---|
| 1 | Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution | Science | 2014 | 1,567 |
| 2 | The Hedgehog and Wnt signalling pathways in cancer | Nature | 2001 | 1,309 |
| 3 | Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development | Science | 1996 | 1,253 |
| 4 | Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine | Nature | 2000 | 1,243 |
| 5 | BACE1 is the major β-secretase for generation of Aβ peptides by neurons | Nature Neuroscience | 2001 | 1,023 |
| 6 | Characterization of the Yeast Transcriptome | Cell | 1997 | 1,009 |
| 7 | Hedgehog signalling in prostate regeneration, neoplasia and metastasis | Nature | 2004 | 959 |
| 8 | High Frequency Retrotransposition in Cultured Mammalian Cells | Cell | 1996 | 950 |
| 9 | Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb | Cell | 2000 | 948 |
| 10 | Induction of Cachexia in Mice by Systemically Administered Myostatin | Science | 2002 | 829 |
| 11 | PCNA: structure, functions and interactions | Oncogene | 1997 | 787 |
| 12 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin | Nature Chemical Biology | 2010 | 757 |
| 13 | Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits | Nature | 1992 | 689 |
| 14 | Crx, a Novel Otx-like Paired-Homeodomain Protein, Binds to and Transactivates Photoreceptor Cell-Specific Genes | Neuron | 1997 | 641 |
| 15 | Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis | Journal of Clinical Investigation | 2017 | 603 |
| 16 | Human L1 Retrotransposition: cis Preference versus trans Complementation | Molecular and Cellular Biology | 2001 | 587 |
| 17 | The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. | Genes and Development | 1995 | 559 |
| 18 | Autoproteolysis in hedgehog protein biogenesis | Science | 1994 | 505 |
| 19 | A DNA Integrity Network in the Yeast Saccharomyces cerevisiae | Cell | 2006 | 490 |
| 20 | Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain | Cell | 1996 | 488 |
| 21 | The product of hedgehog autoproteolytic cleavage active in local and long-range signalling | Nature | 1995 | 483 |
| 22 | Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains | Cell | 2013 | 471 |
| 23 | Regulation of muscle growth by multiple ligands signaling through activin type II receptors | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 447 |
| 24 | Human L1 Retrotransposition Is Associated with Genetic Instability In Vivo | Cell | 2002 | 435 |
| 25 | Identification of a Neuropeptide Hormone That Regulates Sex Pheromone Production in Female Moths | Science | 1989 | 420 |
| 26 | Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery | Genes and Development | 1999 | 420 |
| 27 | Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice | Immunity | 1997 | 414 |
| 28 | Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal | Science | 2001 | 391 |
| 29 | TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1 | Cell | 1995 | 372 |
| 30 | Pathway to Totipotency: Lessons from Germ Cells | Cell | 2006 | 363 |
| 31 | CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition | Cell | 1995 | 361 |
| 32 | Virus-specific Activation of a Novel Interferon Regulatory Factor, IRF-5, Results in the Induction of Distinct Interferon α Genes | Journal of Biological Chemistry | 2001 | 343 |
| 33 | 3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline | Current Biology | 2008 | 342 |
| 34 | Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. | Genetics | 1990 | 342 |
| 35 | A new strategy for genome sequencing | Nature | 1996 | 338 |
| 36 | Regulated nucleosome mobility and the histone code | Nature Structural and Molecular Biology | 2004 | 336 |
| 37 | RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts | Nature | 2001 | 328 |
| 38 | A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment | Journal of Neuroscience | 1994 | 326 |
| 39 | Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease | Journal of Biological Chemistry | 1999 | 322 |
| 40 | Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2 | Nature | 1989 | 302 |
| 41 | A Robust Toolkit for Functional Profiling of the Yeast Genome | Molecular Cell | 2004 | 295 |
| 42 | A nuclear receptor-like pathway regulating multidrug resistance in fungi | Nature | 2008 | 294 |
| 43 | Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro | Cell | 1996 | 292 |
| 44 | Targeted nanopore sequencing with Cas9-guided adapter ligation | Nature Biotechnology | 2020 | 286 |
| 45 | Prevalence of off-target effects in Drosophila RNA interference screens | Nature | 2006 | 274 |
| 46 | Mighty Piwis Defend the Germline against Genome Intruders | Cell | 2007 | 265 |
| 47 | Substrate-assisted catalysis of peptide bond formation by the ribosome | Nature Structural and Molecular Biology | 2004 | 264 |
| 48 | Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity | Cell | 2005 | 264 |
| 49 | Products, genetic linkage and limb patterning activity of a murine hedgehog gene | Development (Cambridge) | 1994 | 263 |
| 50 | Biology and Pathogenesis of Lentiviruses | Journal of General Virology | 1989 | 254 |
