| # | Title | Journal | Year | Citations |
|---|
| 1 | Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE | Nature | 1994 | 2,471 |
| 2 | Barriers to recruiting underrepresented populations to cancer clinical trials: A systematic review | Cancer | 2008 | 866 |
| 3 | Recent progress in pancreatic cancer | Ca-A Cancer Journal for Clinicians | 2013 | 743 |
| 4 | Recent progress in the diagnosis and treatment of ovarian cancer | Ca-A Cancer Journal for Clinicians | 2011 | 618 |
| 5 | Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer | Nature Genetics | 2009 | 597 |
| 6 | The natural polyamine spermine functions directly as a free radical scavenger | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 587 |
| 7 | Detectable clonal mosaicism and its relationship to aging and cancer | Nature Genetics | 2012 | 519 |
| 8 | Epstein-Barr virus in AIDS-related primary central nervous system lymphoma | Lancet, The | 1991 | 513 |
| 9 | Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis -induced colon tumorigenesis | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 482 |
| 10 | Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands | Cancer Cell | 2011 | 452 |
| 11 | Mutation of the PIK3CA oncogene in human cancers | British Journal of Cancer | 2006 | 444 |
| 12 | Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma | Annals of Surgery | 2018 | 425 |
| 13 | Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 423 |
| 14 | An In vivo Platform for Translational Drug Development in Pancreatic Cancer | Clinical Cancer Research | 2006 | 407 |
| 15 | Engineering tailored nanoparticles with microbes: quo vadis? | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology | 2016 | 389 |
| 16 | Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 375 |
| 17 | Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors | Nature Reviews Gastroenterology and Hepatology | 2021 | 370 |
| 18 | Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer | Cell | 2017 | 366 |
| 19 | Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice | Cancer Research | 2001 | 357 |
| 20 | Peripheral neuropathy from taxol and cisplatin combination chemotherapy: Clinical and electrophysiological studies | Annals of Neurology | 1994 | 334 |
| 21 | Gibbon genome and the fast karyotype evolution of small apes | Nature | 2014 | 320 |
| 22 | Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide | Science Translational Medicine | 2013 | 303 |
| 23 | HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 299 |
| 24 | Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists | Cancer Cell | 2013 | 296 |
| 25 | Targeted nanopore sequencing with Cas9-guided adapter ligation | Nature Biotechnology | 2020 | 286 |
| 26 | Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity | Cell | 2005 | 264 |
| 27 | Genetic, Immunohistochemical, and Clinical Features of Medullary Carcinoma of the Pancreas | American Journal of Pathology | 2000 | 263 |
| 28 | Attrition of T Cell Memory | Immunity | 1999 | 261 |
| 29 | The emerging role of epigenetic therapeutics in immuno-oncology | Nature Reviews Clinical Oncology | 2020 | 260 |
| 30 | Antagonists of PD-1 and PD-L1 in Cancer Treatment | Seminars in Oncology | 2015 | 259 |
| 31 | High-Level Variability in the ORF-K1 Membrane Protein Gene at the Left End of the Kaposi’s Sarcoma-Associated Herpesvirus Genome Defines Four Major Virus Subtypes and Multiple Variants or Clades in Different Human Populations | Journal of Virology | 1999 | 236 |
| 32 | A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study | Lancet Haematology,the | 2015 | 232 |
| 33 | Eukaryotic Initiation Factor 2α-independent Pathway of Stress Granule Induction by the Natural Product Pateamine A | Journal of Biological Chemistry | 2006 | 229 |
| 34 | Risk of colorectal cancer in juvenile polyposis | Gut | 2007 | 228 |
| 35 | Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells | Journal of Immunology | 2009 | 224 |
| 36 | Update on Familial Pancreatic Cancer | Advances in Surgery | 2010 | 224 |
| 37 | Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer | Nature Genetics | 2015 | 224 |
| 38 | Phenotypic variation in eight extendedCDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families | Cancer | 2002 | 221 |
| 39 | GSTP1 CpG Island Hypermethylation Is Responsible for the Absence of GSTP1 Expression in Human Prostate Cancer Cells | American Journal of Pathology | 2001 | 219 |
| 40 | Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays | British Journal of Haematology | 2004 | 218 |
| 41 | Epigenetic therapy inhibits metastases by disrupting premetastatic niches | Nature | 2020 | 213 |
| 42 | In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter | Immunity | 1996 | 209 |
| 43 | Current management of glioblastoma multiforme | Seminars in Oncology | 2004 | 206 |
| 44 | Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States | Blood | 1993 | 202 |
| 45 | Mesenchymal markers on human adipose stem/progenitor cells | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2013 | 200 |
| 46 | Association Between Hyperglycemia and Survival in Patients With Newly Diagnosed Glioblastoma | Journal of Clinical Oncology | 2009 | 199 |
| 47 | TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer | Cancer Discovery | 2016 | 196 |
| 48 | Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells | OncoImmunology | 2015 | 195 |
| 49 | Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum | Clinical Cancer Research | 2017 | 193 |
| 50 | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer | Nature Communications | 2018 | 188 |
