| # | Title | Journal | Year | Citations |
|---|
| 1 | Why Don't Physicians Follow Clinical Practice Guidelines? | JAMA - Journal of the American Medical Association | 1999 | 5,548 |
| 2 | Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report | Journal of Allergy and Clinical Immunology | 2010 | 1,614 |
| 3 | A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS | Pediatrics | 1959 | 1,060 |
| 4 | Eosinophilic esophagitis attributed to gastroesophageal reflux: Improvement with an amino acid-based formula | Gastroenterology | 1995 | 1,028 |
| 5 | Bioconversion of lignocellulosic biomass: biochemical and molecular perspectives | Journal of Industrial Microbiology and Biotechnology | 2008 | 962 |
| 6 | Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1 | Journal of Biological Chemistry | 1996 | 951 |
| 7 | The CpG dinucleotide and human genetic disease | Human Genetics | 1988 | 932 |
| 8 | Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man | Nature | 1988 | 840 |
| 9 | An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products | Journal of Pediatrics | 2010 | 782 |
| 10 | Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene | Nature Genetics | 1992 | 715 |
| 11 | Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc | Journal of Biological Chemistry | 2000 | 708 |
| 12 | Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome | Nature Genetics | 1997 | 628 |
| 13 | Connexin 43 (GJA1) Mutations Cause the Pleiotropic Phenotype of Oculodentodigital Dysplasia | American Journal of Human Genetics | 2003 | 585 |
| 14 | Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities | Nature | 2012 | 560 |
| 15 | Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α | Journal of Biological Chemistry | 1997 | 557 |
| 16 | Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression | Critical Reviews in Biochemistry and Molecular Biology | 2000 | 557 |
| 17 | ICON: Food allergy | Journal of Allergy and Clinical Immunology | 2012 | 542 |
| 18 | Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis | Molecular and Cellular Biology | 2005 | 527 |
| 19 | Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways | Oncogene | 2005 | 523 |
| 20 | Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA | Nature | 1987 | 518 |
| 21 | Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2 | Cancer Research | 1999 | 484 |
| 22 | CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 473 |
| 23 | Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2 | Nature Genetics | 1994 | 458 |
| 24 | Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1 | Cancer Research | 2003 | 456 |
| 25 | Adolescent Maturity and the Brain: The Promise and Pitfalls of Neuroscience Research in Adolescent Health Policy | Journal of Adolescent Health | 2009 | 434 |
| 26 | Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia | Blood | 2000 | 422 |
| 27 | A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein | Nature | 1990 | 416 |
| 28 | Regulation of cancer cell metabolism by hypoxia-inducible factor 1 | Seminars in Cancer Biology | 2009 | 410 |
| 29 | Nonrandom association of polymorphic restriction sites in the -globin gene cluster | Proceedings of the National Academy of Sciences of the United States of America | 1982 | 401 |
| 30 | Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants | Journal of Pediatrics | 2013 | 396 |
| 31 | MicroRNAs: Critical Regulators of Development, Cellular Physiology and Malignancy | Cell Cycle | 2005 | 388 |
| 32 | Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans | Nature Genetics | 1995 | 378 |
| 33 | Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity | Nature Medicine | 2006 | 374 |
| 34 | Evaluating Strategies For Reducing Health Disparities By Addressing The Social Determinants Of Health | Health Affairs | 2016 | 371 |
| 35 | The Science of Early Life Toxic Stress for Pediatric Practice and Advocacy | Pediatrics | 2013 | 362 |
| 36 | Oral Human Papillomavirus Infection in Adults Is Associated with Sexual Behavior and HIV Serostatus | Journal of Infectious Diseases | 2004 | 329 |
| 37 | Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 327 |
| 38 | Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium | Nature Genetics | 2009 | 324 |
| 39 | Food Protein-Induced Enterocolitis Syndrome Caused by Solid Food Proteins | Pediatrics | 2003 | 312 |
| 40 | Loop-Mediated Isothermal Amplification for Detection of African Trypanosomes | Journal of Clinical Microbiology | 2003 | 307 |
| 41 | Abnormal RNA processing due to the exon mutation of βE-globin gene | Nature | 1982 | 302 |
| 42 | A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 Infection | American Journal of Respiratory Cell and Molecular Biology | 1991 | 299 |
| 43 | Thyrotropin-Releasing Hormone and the Thyroid Hormone Feedback Mechanism | Endocrinology | 2009 | 291 |
| 44 | Promoting Optimal Development: Identifying Infants and Young Children With Developmental Disorders Through Developmental Surveillance and Screening | Pediatrics | 2020 | 289 |
| 45 | Multi-contrast human neonatal brain atlas: Application to normal neonate development analysis | NeuroImage | 2011 | 277 |
| 46 | Regulation of Metabolism by Hypoxia-Inducible Factor 1 | Cold Spring Harbor Symposia on Quantitative Biology | 2011 | 275 |
| 47 | Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling | Journal of Cellular Biochemistry | 2007 | 269 |
| 48 | The natural history of tree nut allergy | Journal of Allergy and Clinical Immunology | 2005 | 268 |
| 49 | Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa | Lancet Infectious Diseases, The | 2008 | 257 |
| 50 | Tumor metabolism: cancer cells give and take lactate | Journal of Clinical Investigation | 2008 | 254 |
