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Top Articles

#TitleJournalYearCitations
1Three-dimensional tracking of axonal projections in the brain by magnetic resonance imagingAnnals of Neurology19993,317
2Genomic analyses identify molecular subtypes of pancreatic cancerNature20162,700
3APC mutations occur early during colorectal tumorigenesisNature19921,731
4Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalisAnnals of Neurology19811,694
5Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In VivoNeuron19961,471
6Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretaseHuman Molecular Genetics20041,350
7Tissue repair and stem cell renewal in carcinogenesisNature20041,131
8Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In VivoNeuron19961,054
9BACE1 is the major β-secretase for generation of Aβ peptides by neuronsNature Neuroscience20011,023
10Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor ProteinsNeuron1997964
11Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigmHuman Pathology2011932
12Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase InhibitorsScience2000906
13A mouse model for Down syndrome exhibits learning and behaviour deficitsNature Genetics1995854
14Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant RecipientsJAMA - Journal of the American Medical Association2021835
15Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous CarcinomaJournal of the National Cancer Institute2003762
16Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesodermNature1997730
17Co-expression of multiple transgenes in mouse CNS: a comparison of strategiesNew Biotechnology2001712
18GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transportNature2015692
19Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular DevelopmentDevelopmental Cell2003661
20Hashimoto thyroiditis: Clinical and diagnostic criteriaAutoimmunity Reviews2014637
21Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and NecrosisBrain Research Bulletin1998621
22Fatty Acid Synthase and Cancer: New Application of an Old Pathway: Figure 1.Cancer Research2006578
23AMPA glutamate receptor subunits are differentially distributed in rat brainNeuroscience1993575
24Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial NeoplasiaGastroenterology2012568
25C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited.Journal of Immunology1997535
26Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignanciesCancer Research1997529
27Basal forebrain neurons in the dementia of Parkinson diseaseAnnals of Neurology1983527
28HUPO Plasma Proteome Project specimen collection and handling: Towards the standardization of parameters for plasma proteome samplesProteomics2005515
29An Overview of APP Processing Enzymes and ProductsNeuroMolecular Medicine2010515
30Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severityScience2020511
31International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and GradingBrain Pathology2014499
32Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal MitochondriaNeuron2004497
33BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-  Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic FunctionsJournal of Neuroscience2005490
34C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisitedJournal of Immunology1997479
35Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synucleinNeuron2009459
36Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's DiseaseJournal of Neuroscience2005455
37Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healingProceedings of the National Academy of Sciences of the United States of America2011454
38Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant RecipientsJAMA - Journal of the American Medical Association2021452
39Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin MutationsAmerican Journal of Pathology2002451
40MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomasOncogene1998442
41An Update of the Gleason Grading SystemJournal of Urology2010432
42Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal AdenocarcinomaAnnals of Surgery2018425
43Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos diseaseNature Genetics2001422
44Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System: A Highly Malignant Tumor of Infancy and Childhood Frequently Mistaken for MedulloblastomaAmerican Journal of Surgical Pathology1998413
45Recurrent involvement of 2p23 in inflammatory myofibroblastic tumorsCancer Research1999413
46Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat LengthNeurobiology of Disease1998408
47Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancerSurgery2007408
48A Multicenter Study of [-2]Pro-Prostate Specific Antigen Combined With Prostate Specific Antigen and Free Prostate Specific Antigen for Prostate Cancer Detection in the 2.0 to 10.0 ng/ml Prostate Specific Antigen RangeJournal of Urology2011408
49Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary RestenosisCirculation2001401
50Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYCProceedings of the National Academy of Sciences of the United States of America2012399