# | Title | Journal | Year | Citations |
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1 | Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging | Annals of Neurology | 1999 | 3,317 |
2 | Genomic analyses identify molecular subtypes of pancreatic cancer | Nature | 2016 | 2,700 |
3 | APC mutations occur early during colorectal tumorigenesis | Nature | 1992 | 1,731 |
4 | Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis | Annals of Neurology | 1981 | 1,694 |
5 | Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo | Neuron | 1996 | 1,471 |
6 | Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase | Human Molecular Genetics | 2004 | 1,350 |
7 | Tissue repair and stem cell renewal in carcinogenesis | Nature | 2004 | 1,131 |
8 | Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo | Neuron | 1996 | 1,054 |
9 | BACE1 is the major β-secretase for generation of Aβ peptides by neurons | Nature Neuroscience | 2001 | 1,023 |
10 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins | Neuron | 1997 | 964 |
11 | Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm | Human Pathology | 2011 | 932 |
12 | Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors | Science | 2000 | 906 |
13 | A mouse model for Down syndrome exhibits learning and behaviour deficits | Nature Genetics | 1995 | 854 |
14 | Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients | JAMA - Journal of the American Medical Association | 2021 | 835 |
15 | Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma | Journal of the National Cancer Institute | 2003 | 762 |
16 | Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm | Nature | 1997 | 730 |
17 | Co-expression of multiple transgenes in mouse CNS: a comparison of strategies | New Biotechnology | 2001 | 712 |
18 | GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport | Nature | 2015 | 692 |
19 | Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development | Developmental Cell | 2003 | 661 |
20 | Hashimoto thyroiditis: Clinical and diagnostic criteria | Autoimmunity Reviews | 2014 | 637 |
21 | Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis | Brain Research Bulletin | 1998 | 621 |
22 | Fatty Acid Synthase and Cancer: New Application of an Old Pathway: Figure 1. | Cancer Research | 2006 | 578 |
23 | AMPA glutamate receptor subunits are differentially distributed in rat brain | Neuroscience | 1993 | 575 |
24 | Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia | Gastroenterology | 2012 | 568 |
25 | C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. | Journal of Immunology | 1997 | 535 |
26 | Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies | Cancer Research | 1997 | 529 |
27 | Basal forebrain neurons in the dementia of Parkinson disease | Annals of Neurology | 1983 | 527 |
28 | HUPO Plasma Proteome Project specimen collection and handling: Towards the standardization of parameters for plasma proteome samples | Proteomics | 2005 | 515 |
29 | An Overview of APP Processing Enzymes and Products | NeuroMolecular Medicine | 2010 | 515 |
30 | Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity | Science | 2020 | 511 |
31 | International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading | Brain Pathology | 2014 | 499 |
32 | Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria | Neuron | 2004 | 497 |
33 | BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid- Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions | Journal of Neuroscience | 2005 | 490 |
34 | C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited | Journal of Immunology | 1997 | 479 |
35 | Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein | Neuron | 2009 | 459 |
36 | Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease | Journal of Neuroscience | 2005 | 455 |
37 | Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 454 |
38 | Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients | JAMA - Journal of the American Medical Association | 2021 | 452 |
39 | Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin Mutations | American Journal of Pathology | 2002 | 451 |
40 | MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas | Oncogene | 1998 | 442 |
41 | An Update of the Gleason Grading System | Journal of Urology | 2010 | 432 |
42 | Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma | Annals of Surgery | 2018 | 425 |
43 | Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease | Nature Genetics | 2001 | 422 |
44 | Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System: A Highly Malignant Tumor of Infancy and Childhood Frequently Mistaken for Medulloblastoma | American Journal of Surgical Pathology | 1998 | 413 |
45 | Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors | Cancer Research | 1999 | 413 |
46 | Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat Length | Neurobiology of Disease | 1998 | 408 |
47 | Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer | Surgery | 2007 | 408 |
48 | A Multicenter Study of [-2]Pro-Prostate Specific Antigen Combined With Prostate Specific Antigen and Free Prostate Specific Antigen for Prostate Cancer Detection in the 2.0 to 10.0 ng/ml Prostate Specific Antigen Range | Journal of Urology | 2011 | 408 |
49 | Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis | Circulation | 2001 | 401 |
50 | Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 399 |