| # | Title | Journal | Year | Citations |
|---|
| 1 | Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US | JAMA Internal Medicine | 2020 | 711 |
| 2 | The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I | Cell | 1996 | 558 |
| 3 | Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 527 |
| 4 | Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease | Blood | 2014 | 462 |
| 5 | Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 | JAMA Internal Medicine | 2021 | 385 |
| 6 | Shear stress and the endothelium | Kidney International | 1998 | 333 |
| 7 | Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro | Journal of Biological Chemistry | 2007 | 318 |
| 8 | DASH (Dietary Approaches to Stop Hypertension) Diet and Risk of Subsequent Kidney Disease | American Journal of Kidney Diseases | 2016 | 221 |
| 9 | AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 | Journal of the American Society of Nephrology: JASN | 2021 | 207 |
| 10 | Somatic Mutation in Individual Liver Cysts Supports a Two-Hit Model of Cystogenesis in Autosomal Dominant Polycystic Kidney Disease | Molecular Cell | 1998 | 192 |
| 11 | Blood Pressure Excursions Below the Cerebral Autoregulation Threshold During Cardiac Surgery are Associated With Acute Kidney Injury* | Critical Care Medicine | 2013 | 183 |
| 12 | Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells | Journal of Biological Chemistry | 1996 | 160 |
| 13 | Biomarkers of Acute and Chronic Kidney Disease | Annual Review of Physiology | 2019 | 159 |
| 14 | Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region | Journal of Biological Chemistry | 1998 | 155 |
| 15 | Effectiveness of Educational and Social Worker Interventions to Activate Patients' Discussion and Pursuit of Preemptive Living Donor Kidney Transplantation: A Randomized Controlled Trial | American Journal of Kidney Diseases | 2013 | 145 |
| 16 | A Flagellar Polycystin-2 Homolog Required for Male Fertility in Drosophila | Current Biology | 2003 | 142 |
| 17 | Polycystin-1 regulates STAT activity by a dual mechanism | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 125 |
| 18 | The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21 | Genomics | 1995 | 119 |
| 19 | Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP | American Journal of Physiology - Cell Physiology | 2001 | 119 |
| 20 | WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells | Kidney International | 2006 | 119 |
| 21 | TonEBP transcriptional activator in the cellular response to increased osmolality | Pflugers Archiv European Journal of Physiology | 2002 | 117 |
| 22 | Retroperitoneal Fibrosis | Medicine (United States) | 2009 | 113 |
| 23 | Cis- andtrans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity | American Journal of Physiology - Renal Physiology | 1998 | 103 |
| 24 | Post–Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression | JAMA Internal Medicine | 2020 | 98 |
| 25 | Gene conversion is a likely cause of mutation in PKD1 | Human Molecular Genetics | 1998 | 89 |
| 26 | Characterization of cis-Autoproteolysis of Polycystin-1, the Product of Human Polycystic Kidney Disease 1 Gene | Journal of Biological Chemistry | 2007 | 88 |
| 27 | HIV Type 1 RNA Level as a Clinical Indicator of Renal Pathology in HIV‐Infected Patients | Clinical Infectious Diseases | 2006 | 85 |
| 28 | A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death | Kidney International | 2021 | 72 |
| 29 | Eculizumab cessation in atypical hemolytic uremic syndrome | Blood | 2017 | 70 |
| 30 | Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca2+ Entry through Interactions with STIM1 | PLoS ONE | 2010 | 64 |
| 31 | Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay | journal of applied laboratory medicine, The | 2019 | 61 |
| 32 | Aortic abnormalities in males with Alport syndrome | Nephrology Dialysis Transplantation | 2010 | 60 |
| 33 | Treatment of the anemia of chronic renal failure with subcutaneous recombinant human erythropoietin | American Journal of Medicine | 1990 | 58 |
| 34 | Long COVID and kidney disease | Nature Reviews Nephrology | 2021 | 58 |
| 35 | Contrast-Associated Acute Kidney Injury and Serious Adverse Outcomes Following Angiography | Journal of the American College of Cardiology | 2020 | 57 |
| 36 | Transcriptional regulation by changes in tonicity | Kidney International | 2001 | 56 |
| 37 | “Mistakes Happen”: Somatic Mutation and Disease | American Journal of Human Genetics | 1997 | 54 |
| 38 | A missense mutation in PKD1 attenuates the severity of renal disease | Kidney International | 2012 | 54 |
| 39 | Rituximab and Therapeutic Plasma Exchange in Recurrent Focal Segmental Glomerulosclerosis Postkidney Transplantation | Transplantation | 2018 | 50 |
| 40 | Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus | Journal of Bioenergetics and Biomembranes | 1995 | 48 |
| 41 | Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene | Biochimica Et Biophysica Acta Gene Regulatory Mechanisms | 1999 | 47 |
| 42 | Disparities in Provision of Transplant Education by Profit Status of the Dialysis Center | American Journal of Transplantation | 2012 | 47 |
| 43 | Purification and reconstitution of functional human P-glycoprotein | Journal of Bioenergetics and Biomembranes | 1995 | 46 |
| 44 | High-sensitivity cardiac troponin and natriuretic peptide with risk of lower-extremity peripheral artery disease: the Atherosclerosis Risk in Communities (ARIC) Study | European Heart Journal | 2018 | 46 |
| 45 | Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival | JAMA Network Open | 2020 | 46 |
| 46 | Reduced Racial Disparity in Kidney Transplant Outcomes in the United States from 1990 to 2012 | Journal of the American Society of Nephrology: JASN | 2016 | 45 |
| 47 | Teprasiran, a Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study | Circulation | 2021 | 42 |
| 48 | Screening for Chronic Kidney Disease in HIV-Infected Patients | Advances in Chronic Kidney Disease | 2010 | 41 |
| 49 | The Structural Organization of the Human Na+/Myo-inositol Cotransporter (SLC5A3) Gene and Characterization of the Promoter | Genomics | 1997 | 39 |
| 50 | Retroperitoneal Fibrosis | Rheumatic Disease Clinics of North America | 2013 | 39 |
