# | Title | Journal | Year | Citations |
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1 | A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease | Nature | 2001 | 4,589 |
2 | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology | Canadian Journal of Gastroenterology & Hepatology | 2005 | 2,711 |
3 | Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas | Gastroenterology | 1994 | 2,329 |
4 | Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart | Circulation | 2002 | 2,078 |
5 | Frailty as a Predictor of Surgical Outcomes in Older Patients | Journal of the American College of Surgeons | 2010 | 1,731 |
6 | c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism | Molecular and Cellular Biology | 1999 | 1,501 |
7 | Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia | Journal of Biological Chemistry | 2008 | 1,424 |
8 | Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction | Circulation | 1998 | 1,272 |
9 | Very high risk of cancer in familial Peutz–Jeghers syndrome | Gastroenterology | 2000 | 1,247 |
10 | The prevalence and etiology of elevated aminotransferase levels in the United States | American Journal of Gastroenterology | 2003 | 1,164 |
11 | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 1,150 |
12 | Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis | Hepatology | 2011 | 1,128 |
13 | Clinical Response to Aminoglycoside Therapy: Importance of the Ratio of Peak Concentration to Minimal Inhibitory Concentration | Journal of Infectious Diseases | 1987 | 1,104 |
14 | Antibiotic-Associated Diarrhea | New England Journal of Medicine | 2002 | 1,097 |
15 | HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells | Cell | 2007 | 1,068 |
16 | Competing Risk Regression Models for Epidemiologic Data | American Journal of Epidemiology | 2009 | 984 |
17 | Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis | Science | 1990 | 949 |
18 | c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 944 |
19 | Combined Ventricular Systolic and Arterial Stiffening in Patients With Heart Failure and Preserved Ejection Fraction | Circulation | 2003 | 878 |
20 | BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications | Endocrine Reviews | 2007 | 857 |
21 | Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease | Neuron | 2019 | 830 |
22 | From structure to disease: the evolving tale of aquaporin biology | Nature Reviews Molecular Cell Biology | 2004 | 829 |
23 | Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc | Journal of Biological Chemistry | 2000 | 708 |
24 | Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation | Cancer Cell | 2010 | 707 |
25 | Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 642 |
26 | Superoxide Generation from Endothelial Nitric-oxide Synthase | Journal of Biological Chemistry | 1998 | 638 |
27 | Cardiac Resynchronization and Death From Progressive Heart Failure | JAMA - Journal of the American Medical Association | 2003 | 633 |
28 | Patients With Depression Are Less Likely to Follow Recommendations to Reduce Cardiac Risk During Recovery From a Myocardial Infarction | Archives of Internal Medicine | 2000 | 594 |
29 | Identification and Characterization of a Gene Encoding a Gut-enriched Krüppel-like Factor Expressed during Growth Arrest | Journal of Biological Chemistry | 1996 | 591 |
30 | THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI | Journal of Experimental Medicine | 1933 | 590 |
31 | The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I | Cell | 1996 | 558 |
32 | Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II | Circulation Research | 1999 | 557 |
33 | Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction | Nature Medicine | 2010 | 549 |
34 | Narrative Review: The New Epidemic of Clostridium difficile–Associated Enteric Disease | Annals of Internal Medicine | 2006 | 529 |
35 | Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis | Molecular and Cellular Biology | 2005 | 527 |
36 | The Yeast Endosomal Na+(K+)/H+ Exchanger Nhx1 Regulates Cellular pH to Control Vesicle Trafficking | Molecular Biology of the Cell | 2005 | 518 |
37 | Epstein-Barr virus in AIDS-related primary central nervous system lymphoma | Lancet, The | 1991 | 513 |
38 | Depression Is a Risk Factor for Coronary Artery Disease in Men | Archives of Internal Medicine | 1998 | 502 |
39 | SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 496 |
40 | Evolutionary origins of eukaryotic sodium/proton exchangers | American Journal of Physiology - Cell Physiology | 2005 | 492 |
41 | Nitrosative stress drives heart failure with preserved ejection fraction | Nature | 2019 | 492 |
42 | NEUROPSYCHIATRIC MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS: DIAGNOSIS, CLINICAL SPECTRUM, AND RELATIONSHIP TO OTHER FEATURES OF THE DISEASE | Medicine (United States) | 1976 | 483 |
43 | Theoretical Basis of Indicator-Dilution Methods For Measuring Flow and Volume | Circulation Research | 1962 | 480 |
44 | Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen | Immunity | 1996 | 478 |
45 | Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems | Journal of Biological Chemistry | 1998 | 478 |
46 | Prevalence of Obesity and Diabetes in Patients With Cryptogenic Cirrhosis: A Case-Control Study | Hepatology | 2000 | 476 |
47 | A clinician's guide to X-linked hypophosphatemia | Journal of Bone and Mineral Research | 2011 | 476 |
48 | Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure | Circulation Research | 1996 | 467 |
49 | Global mapping of c-Myc binding sites and target gene networks in human B cells | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 462 |
50 | Risk Factors for Chronic Kidney Disease: A Prospective Study of 23,534 Men and Women in Washington County, Maryland | Journal of the American Society of Nephrology: JASN | 2003 | 453 |