Department of Biochemistry and Biotechnology

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#	Title	Journal	Year	Citations
1	Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support	Nucleic Acids Research	1989	809
2	A synthetic IgG-binding domain based on staphylococcal protein A	Protein Engineering, Design and Selection	1987	662
3	Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG	Structure	1995	340
4	On the interfacial activation of Candida antarctica lipase A and B as compared with Humicola lanuginosa lipase	Lipids and Lipid Metabolism	1995	289
5	Toxicokinetics of ochratoxin A in several species and its plasma-binding properties	Journal of Applied Toxicology	1989	242
6	A combinatorial library of an α-helical bacterial receptor domain	Protein Engineering, Design and Selection	1995	226
7	Intermediary Metabolism in Clostridium acetobutylicum : Levels of Enzymes Involved in the Formation of Acetate and Butyrate	Applied and Environmental Microbiology	1984	210
8	Substrate gradient formation in the large-scale bioreactor lowers cell yield and increases by-product formation	Bioprocess and Biosystems Engineering	1998	182
9	Engineering proteins to facilitate bioprocessing	Trends in Biotechnology	1994	173
10	Location of cellulose and callose in pollen tubes and grains of Nicotiana tabacum	Planta	1998	173
11	Substrate gradients in bioreactors: origin and consequences	Bioprocess and Biosystems Engineering	1996	168
12	Solid Phase DNA Minisequencing by an Enzymatic Luminometric Inorganic Pyrophosphate Detection Assay	Analytical Biochemistry	1993	167
13	High-level production of uniformly 15N-and 13C-enriched fusion proteins in Escherichia coli	Journal of Biomolecular NMR	1996	164
14	Factors influencing inclusion body formation in the production of a fused protein in Escherichia coli	Applied and Environmental Microbiology	1991	151
15	Ochratoxin A in Cow’s Milk and in Human Milk with Corresponding Human Blood Samples	Journal of AOAC INTERNATIONAL	1993	143
16	Bacillus sporothermodurans, a New Species Producing Highly Heat-Resistant Endospores	International Journal of Systematic Bacteriology	1996	141
17	Ochratoxin A in human blood and Balkan endemic nephropathy	Archives of Toxicology	1982	140
18	Plasma ochratoxin A levels in three Swedish populations surveyed using an ion‐pair HPLC technique	Food Additives and Contaminants	1991	140
19	Mutational analysis of the interaction between staphylococcal protein A and human IgG1	Protein Engineering, Design and Selection	1993	137
20	Phylogeny of the Mycoplasma mycoides cluster as determined by sequence analysis of the 16S rRNA genes from the two rRNA operons	Journal of Bacteriology	1996	137
21	Studies related to the scale-up of high-cell-densityE. coli fed-batch fermentations using multiparameter flow cytometry: Effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration	Biotechnology and Bioengineering	2000	136
22	Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B	BBA - Proteins and Proteomics	1995	134
23	Phylogeny of Some Mycoplasmas from Ruminants Based on 16S rRNA Sequences and Definition of a New Cluster within the Hominis Group	International Journal of Systematic Bacteriology	1996	133
24	Cell surface display of recombinant proteins on Staphylococcus carnosus	Journal of Bacteriology	1995	132
25	Induction of Protective Immunity in Rodents by Vaccination with a Prokaryotically Expressed Recombinant Fusion Protein Containing a Respiratory Syncytial Virus G Protein Fragment	Virology	1997	131
26	Single–Step Recovery of a Secreted Recombinant Protein by Expanded Bed Adsorption	Bio/technology	1994	129
27	A Process for large-scale isolation of ?-galactosidase fromE. coli in an aqueous two-phase system	Biotechnology and Bioengineering	1983	127
28	Fusion proteins in biotechnology	Current Opinion in Biotechnology	1992	124
29	Mechanisms of ammonia and ammonium ion toxicity in animal cells: Transport across cell membranes	Journal of Biotechnology	1993	118
30	Disulfide exchange folding of insulin-like growth factor I	Biochemistry	1992	114
31	Influence of substrate oscillations on acetate formation and growth yield inEscherichia coliglucose limited fed-batch cultivations	Biotechnology and Bioengineering	1995	114
32	Surface display of a functional single-chain Fv antibody on staphylococci	Journal of Bacteriology	1996	108
33	Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures	Biotechnology and Bioengineering	1994	104
34	Uptake and activation of acetate and butyrate in Clostridium acetobutylicum	Applied Microbiology and Biotechnology	1984	102
35	Molecular pathology in basal cell cancer with p53 as a genetic marker	Oncogene	1997	100
36	Chiral Recognition Of Alcohol Enantiomers In Acyl Transfer Reactions Catalysed ByCandida AntarcticaLipase B	Biocatalysis and Biotransformation	1998	97
37	Phylogenetic analysis of rabbit haemorrhagic disease and European brown hare syndrome viruses by comparison of sequences from the capsid protein gene	Archives of Virology	1997	96
38	Enhanced in vitro Refolding of Insulin-like Growth Factor I Using a Solubilizing Fusion Partner	Biochemistry	1994	93
39	Persistent p53 Mutations in Single Cells from Normal Human Skin	American Journal of Pathology	2001	93
40	Upstream Strategies to Minimize Proteolytic Degradation upon Recombinant Production inEscherichia coli	Protein Expression and Purification	1996	91
41	Control of in vivo proteolysis in the production of recombinant proteins	Trends in Biotechnology	1992	87
42	Physiology of cultured animal cells	Journal of Biotechnology	1997	87
43	Kinetic resolutions of amine and thiol analogues of secondary alcohols catalyzed by the Candida antarctica lipase B	Enzyme and Microbial Technology	1996	86
44	Immobilization and affinity purification of recombinant proteins using histidine peptide fusions	FEBS Journal	1989	85
45	Comparison of the Baker's yeast process performance in laboratory and production scale	Bioprocess and Biosystems Engineering	1998	85
46	Expression of recombinant proteins on the surface of the coagulase-negative bacterium Staphylococcus xylosus	Journal of Bacteriology	1992	83
47	A scale-down two-compartment reactor with controlled substrate oscillations: Metabolic response of Saccharomyces cerevisiae	Bioprocess and Biosystems Engineering	1993	83
48	The Mechanism of Binding Staphylococcal Protein A to Immunoglobin G Does Not Involve Helix Unwinding†	Biochemistry	1996	82
49	Transfer of Bacillus lentimorbus and Bacillus popilliae to the genus Paenibacillus with emended descriptions of Paenibacillus lentimorbus comb. nov. and Paenibacillus popilliae comb. nov.	International Journal of Systematic and Evolutionary Microbiology	1999	82
50	Engineering Proteins to Enhance their Partition Coefficients in Aqueous Two-Phase Systems	Nature Biotechnology	1991	81

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