| # | Title | Journal | Year | Citations |
|---|
| 1 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 2 | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases | Frontiers in Immunology | 2019 | 1,956 |
| 3 | Common variants associated with plasma triglycerides and risk for coronary artery disease | Nature Genetics | 2013 | 754 |
| 4 | Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation | Diabetes | 2015 | 734 |
| 5 | Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma | Nature Genetics | 2011 | 501 |
| 6 | The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies | BMC Endocrine Disorders | 2014 | 440 |
| 7 | New gene functions in megakaryopoiesis and platelet formation | Nature | 2011 | 401 |
| 8 | Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids | American Journal of Physiology - Renal Physiology | 2013 | 401 |
| 9 | Targeting senescent cells alleviates obesity‐induced metabolic dysfunction | Aging Cell | 2019 | 395 |
| 10 | Seventy-five genetic loci influencing the human red blood cell | Nature | 2012 | 320 |
| 11 | A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis | Circulation Research | 2019 | 226 |
| 12 | Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target | Frontiers in Immunology | 2019 | 206 |
| 13 | VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications | Cell Metabolism | 2016 | 180 |
| 14 | Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet | British Journal of Nutrition | 2010 | 177 |
| 15 | Measuring Residual Estrogen Receptor Availability during Fulvestrant Therapy in Patients with Metastatic Breast Cancer | Cancer Discovery | 2015 | 168 |
| 16 | The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease | Journal of Nutritional Biochemistry | 2016 | 155 |
| 17 | Vitamin D status and outcomes in heart failure patients | European Journal of Heart Failure | 2011 | 147 |
| 18 | Fenofibrate Simultaneously Induces Hepatic Fatty Acid Oxidation, Synthesis, and Elongation in Mice | Journal of Biological Chemistry | 2009 | 141 |
| 19 | Immuno‐miRs: critical regulators of T‐cell development, function and ageing | Immunology | 2015 | 141 |
| 20 | Pantethine rescues a Drosophila model for pantothenate kinase–associated neurodegeneration | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 132 |
| 21 | Dietary Influences on Plasma and Urinary Metanephrines: Implications for Diagnosis of Catecholamine-Producing Tumors | Journal of Clinical Endocrinology and Metabolism | 2009 | 131 |
| 22 | Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography–tandem mass spectrometry | Analytical and Bioanalytical Chemistry | 2011 | 130 |
| 23 | High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice | PLoS ONE | 2009 | 126 |
| 24 | Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial | International Journal of Cancer | 2009 | 123 |
| 25 | Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion | Cell Metabolism | 2016 | 119 |
| 26 | The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation | Gut | 2013 | 118 |
| 27 | Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection | Journal of Infectious Diseases | 2015 | 118 |
| 28 | The Many Faces of Cobalamin (Vitamin B12) Deficiency | Mayo Clinic Proceedings Innovations, Quality & Outcomes | 2019 | 117 |
| 29 | Aging disturbs the balance between effector and regulatory CD4+ T cells | Experimental Gerontology | 2014 | 115 |
| 30 | Associations between smoking, components of metabolic syndrome and lipoprotein particle size | BMC Medicine | 2013 | 109 |
| 31 | Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice | Gastroenterology | 2017 | 109 |
| 32 | Variability of biomarkers in patients with chronic heart failure and healthy controls | European Journal of Heart Failure | 2017 | 102 |
| 33 | High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis | Allergy: European Journal of Allergy and Clinical Immunology | 2012 | 98 |
| 34 | Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1 | PLoS ONE | 2015 | 97 |
| 35 | Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets | PLoS ONE | 2015 | 95 |
| 36 | Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4 | Journal of Hepatology | 2015 | 94 |
| 37 | Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat | Diabetologia | 2010 | 92 |
| 38 | Effect of a lifestyle intervention in obese infertile women on cardiometabolic health and quality of life: A randomized controlled trial | PLoS ONE | 2018 | 91 |
| 39 | Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers | PLoS ONE | 2013 | 88 |
| 40 | De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation | Journal of Lipid Research | 2011 | 86 |
| 41 | Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? | Psychoneuroendocrinology | 2014 | 86 |
| 42 | Bile salt sequestration induces hepaticde novolipogenesis through farnesoid X receptor- and liver X receptorα-controlled metabolic pathways in mice | Hepatology | 2010 | 84 |
| 43 | Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors | Hormones and Cancer | 2015 | 83 |
| 44 | Higher mast cell load decreases the risk of Hymenoptera venom–induced anaphylaxis in patients with mastocytosis | Journal of Allergy and Clinical Immunology | 2013 | 81 |
| 45 | Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease | Journal of Neurochemistry | 2019 | 81 |
| 46 | Prevalence of indolent systemic mastocytosis in a Dutch region | Journal of Allergy and Clinical Immunology | 2013 | 78 |
| 47 | No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid Hormone Parameters, Health-Related Quality of Life, and Cognitive Functioning in a Large Population-Based Cohort Study | Thyroid | 2017 | 78 |
| 48 | Psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients: A critical review of the literature | Neuroscience and Biobehavioral Reviews | 2010 | 77 |
| 49 | Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice | Laboratory Investigation | 2010 | 77 |
| 50 | TheATG16L1–T300Aallele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients | Gut | 2015 | 77 |
