| # | Title | Journal | Year | Citations |
|---|
| 1 | Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders | Nature | 2011 | 2,806 |
| 2 | SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes | Nature Medicine | 2020 | 2,182 |
| 3 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 4 | The Human Cell Atlas | ELife | 2017 | 1,547 |
| 5 | Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma | Cancer Cell | 2013 | 856 |
| 6 | Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19) | Journal of Pathology | 2020 | 791 |
| 7 | Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics | Nature | 2012 | 759 |
| 8 | Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury | Journal of the American Society of Nephrology: JASN | 2009 | 751 |
| 9 | A cellular census of human lungs identifies novel cell states in health and in asthma | Nature Medicine | 2019 | 631 |
| 10 | Double-hit B-cell lymphomas | Blood | 2011 | 603 |
| 11 | Chronic inflammation induces telomere dysfunction and accelerates ageing in mice | Nature Communications | 2014 | 596 |
| 12 | MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers | Nature | 2011 | 551 |
| 13 | Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes | Nature Genetics | 2017 | 472 |
| 14 | Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease | Antioxidants and Redox Signaling | 2009 | 445 |
| 15 | For better or for worse: the role of Pim oncogenes in tumorigenesis | Nature Reviews Cancer | 2011 | 423 |
| 16 | Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors | European Heart Journal | 2020 | 381 |
| 17 | Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health? | Current Opinion in Clinical Nutrition and Metabolic Care | 2010 | 368 |
| 18 | Endothelial to Mesenchymal Transition in Cardiovascular Disease | Journal of the American College of Cardiology | 2019 | 357 |
| 19 | Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge | Frontiers in Medicine | 2015 | 350 |
| 20 | New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries | Nature Genetics | 2019 | 350 |
| 21 | Brain pathology of spinocerebellar ataxias | Acta Neuropathologica | 2012 | 337 |
| 22 | Reactive oxygen species (ROS) in macrophage activation and function in diabetes | Immunobiology | 2019 | 333 |
| 23 | Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis | Nature Genetics | 2017 | 306 |
| 24 | Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma | PLoS Genetics | 2012 | 261 |
| 25 | Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets | Nature Genetics | 2017 | 257 |
| 26 | Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice | Frontiers in Immunology | 2017 | 252 |
| 27 | Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System | Advanced Materials | 2012 | 247 |
| 28 | Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression | PLoS Genetics | 2013 | 247 |
| 29 | Oxidative stress in placental pathology | Placenta | 2018 | 246 |
| 30 | The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine | Antioxidants and Redox Signaling | 2017 | 244 |
| 31 | Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci | American Journal of Human Genetics | 2012 | 239 |
| 32 | Endothelial–mesenchymal transition in atherosclerosis | Cardiovascular Research | 2018 | 239 |
| 33 | Polymers in cell encapsulation from an enveloped cell perspective | Advanced Drug Delivery Reviews | 2014 | 237 |
| 34 | Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction | European Journal of Heart Failure | 2019 | 236 |
| 35 | Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study | Lancet Respiratory Medicine,the | 2017 | 233 |
| 36 | Ductular reactions in human liver: Diversity at the interface | Hepatology | 2011 | 232 |
| 37 | MicroRNAs, macrocontrol: Regulation of miRNA processing | Rna | 2010 | 229 |
| 38 | Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan | Nature Cell Biology | 2013 | 229 |
| 39 | Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci | American Journal of Human Genetics | 2012 | 227 |
| 40 | Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells | Respiratory Research | 2013 | 227 |
| 41 | Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure | American Journal of Respiratory Cell and Molecular Biology | 2018 | 217 |
| 42 | The Brainstem Pathologies of Parkinson's Disease and Dementia with Lewy Bodies | Brain Pathology | 2015 | 214 |
| 43 | Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis | American Journal of Respiratory and Critical Care Medicine | 2020 | 208 |
| 44 | Pericyte Migration | Diabetes | 2008 | 207 |
| 45 | Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts | Cell Communication and Signaling | 2013 | 203 |
| 46 | High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice | Aging | 2015 | 201 |
| 47 | The extracellular matrix – the under‐recognized element in lung disease? | Journal of Pathology | 2016 | 195 |
| 48 | Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner | Nature Communications | 2016 | 195 |
| 49 | Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression | PLoS Genetics | 2012 | 194 |
| 50 | Glomerular and Tubular Damage Markers Are Elevated in Patients With Diabetes | Diabetes Care | 2011 | 191 |
