| # | Title | Journal | Year | Citations |
|---|
| 1 | Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices | Journal of Pharmaceutical Sciences | 1963 | 3,810 |
| 2 | Development of the asthma control test☆A survey for assessing asthma control | Journal of Allergy and Clinical Immunology | 2004 | 2,249 |
| 3 | Chronic catheterization of the spinal subarachnoid space | Physiology and Behavior | 1976 | 2,161 |
| 4 | The Stability of Cyclodextrin Complexes in Solution | Chemical Reviews | 1997 | 2,019 |
| 5 | Characteristics and Significance of the Amorphous State in Pharmaceutical Systems | Journal of Pharmaceutical Sciences | 1997 | 1,598 |
| 6 | Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity | Toxicological Sciences | 2005 | 1,100 |
| 7 | Amphiphilic block copolymers for drug delivery | Journal of Pharmaceutical Sciences | 2003 | 943 |
| 8 | Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems | Expert Opinion on Drug Delivery | 2010 | 917 |
| 9 | Analgesia mediated by a direct spinal action of narcotics | Science | 1976 | 916 |
| 10 | Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures | Pharmaceutical Research | 1995 | 788 |
| 11 | Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery | Advanced Drug Delivery Reviews | 2002 | 724 |
| 12 | Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis | Journal of Biological Chemistry | 2003 | 691 |
| 13 | Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress | Journal of Neuroscience | 2003 | 684 |
| 14 | Organic Glasses with Exceptional Thermodynamic and Kinetic Stability | Science | 2007 | 647 |
| 15 | Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques | Pain | 1977 | 625 |
| 16 | Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights | Analytical Chemistry | 2018 | 625 |
| 17 | The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids | Pharmaceutical Research | 1994 | 617 |
| 18 | Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray | Brain Research | 1976 | 602 |
| 19 | Developmental and Reproductive Toxicity of Dioxins and Related Compounds: Cross-Species Comparisons | Critical Reviews in Toxicology | 1993 | 586 |
| 20 | Doxorubicin-loaded poly(ethylene glycol)–poly(β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance | Journal of Controlled Release | 2000 | 577 |
| 21 | Analysis of Data on the Medicament Release from Ointments | Journal of Pharmaceutical Sciences | 1962 | 532 |
| 22 | Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay | Biochemistry | 1991 | 526 |
| 23 | The brief medication questionnaire: A tool for screening patient adherence and barriers to adherence | Patient Education and Counseling | 1999 | 509 |
| 24 | Polymeric Micelles for Drug Delivery | Current Pharmaceutical Design | 2006 | 508 |
| 25 | The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state | International Journal of Pharmaceutics | 1990 | 505 |
| 26 | Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation bytert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult | Journal of Neuroscience | 2004 | 504 |
| 27 | An Important Role of Nrf2-ARE Pathway in the Cellular Defense Mechanism | BMB Reports | 2004 | 503 |
| 28 | Nrf2, a multi‐organ protector? | FASEB Journal | 2005 | 468 |
| 29 | Feeling bad on Facebook: depression disclosures by college students on a social networking site | Depression and Anxiety | 2011 | 448 |
| 30 | Bioadhesive‐Based Dosage Forms: The Next Generation | Journal of Pharmaceutical Sciences | 2000 | 437 |
| 31 | Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds | Critical Reviews in Therapeutic Drug Carrier Systems | 2003 | 418 |
| 32 | Drug Delivery via the Mucous Membranes of the Oral Cavity | Journal of Pharmaceutical Sciences | 1992 | 415 |
| 33 | Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery | Nature Biotechnology | 1997 | 409 |
| 34 | Crystallization of Indomethacin from the Amorphous State below and above Its Glass Transition Temperature | Journal of Pharmaceutical Sciences | 1994 | 408 |
| 35 | Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization | Pharmaceutical Research | 1999 | 380 |
| 36 | Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery II: Synthesis and Evaluation of Some Swelling, Water-Insoluble Bioadhesive Polymers | Journal of Pharmaceutical Sciences | 1985 | 373 |
| 37 | Curcumin for chemoprevention of colon cancer | Cancer Letters | 2007 | 361 |
| 38 | Dissolution Behavior of Crystalline Solvated and Nonsolvated Forms of Some Pharmaceuticals | Journal of Pharmaceutical Sciences | 1963 | 358 |
| 39 | In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin | Toxicology and Applied Pharmacology | 1992 | 358 |
| 40 | Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion | International Journal of Pharmaceutics | 1984 | 342 |
| 41 | Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly | Advanced Drug Delivery Reviews | 2011 | 331 |
| 42 | A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer | Science | 2009 | 321 |
| 43 | Enantioselective Bromolactonization of Conjugated (Z)-Enynes | Journal of the American Chemical Society | 2010 | 321 |
| 44 | Review of the Refeeding Syndrome | Nutrition in Clinical Practice | 2005 | 318 |
| 45 | Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699 | Chemistry and Biology | 1998 | 316 |
| 46 | In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin | Toxicology and Applied Pharmacology | 1992 | 314 |
| 47 | Allenamides: A Powerful and Versatile Building Block in Organic Synthesis | Chemical Reviews | 2013 | 309 |
| 48 | Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels | Pharmaceutical Research | 1987 | 306 |
| 49 | Early Life Stage Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Zebrafish (Danio rerio) | Toxicology and Applied Pharmacology | 1997 | 304 |
| 50 | Assessing the performance of amorphous solid dispersions | Journal of Pharmaceutical Sciences | 2012 | 301 |
