Department of Rheumatology

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#	Title	Journal	Year	Citations
1	The contribution of H LA to rheumatoid arthritis	Clinical Genetics	1989	325
2	Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines	Annals of the Rheumatic Diseases	2002	176
3	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	Arthritis Research	2005	153
4	The Metallo-Disintegrin ADAM10 (MADM) from Bovine Kidney Has Type IV Collagenase Activityin Vitro	Biochemical and Biophysical Research Communications	1998	119
5	Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline	Journal of Bone and Mineral Research	2019	102
6	Activation of procollagenases is a key control point in cartilage collagen degradation: Interaction of serine and metalloproteinase pathways	Arthritis and Rheumatism	2001	94
7	Hormone-sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophages	FEBS Letters	1989	82
8	PRIMARY SJÖGREN'S SYNDROME IN NORTH EAST ENGLAND-A LONGITUDINAL STUDY	Rheumatology	1991	80
9	The Regulation of MMPs and TIMPs in Cartilage Turnover	Annals of the New York Academy of Sciences	1999	80
10	Synergistic induction of matrix metalloproteinase 1 by interleukin-1? and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism	Arthritis and Rheumatism	2001	78
11	Recurrence risk for psoriasis and psoriatic arthritis within sibships	Rheumatology	2005	74
12	More 'cries from the joints': assessment of the musculoskeletal system is poorly documented in routine paediatric clerking	British Journal of Rheumatology	2004	66
13	Localization of ADAM10 and notch receptors in bone	Bone	1999	63
14	Anti-TNFα Therapy Modulates the Phenotype of Peripheral Blood CD4+T Cells in Patients with Posterior Segment Intraocular Inflammation		2004	59
15	ADAM gene expression and regulation during human osteoclast formation	Bone	2004	59
16	Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls	Annals of the Rheumatic Diseases	2001	54
17	Abnormally-fucosylated serum haptoglobins in patients with inflammatory joint disease	Clinica Chimica Acta	1989	53
18	The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis	Current Opinion in Pharmacology	2001	52
19	Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts	Cellular Signalling	2004	50
20	Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines	Annals of the Rheumatic Diseases	2001	41
21	Phosphorylation and activation of hormone-sensitive lipase in isolated macrophages	FEBS Letters	1991	40
22	Drugs in development: bisphosphonates and metalloproteinase inhibitors	Arthritis Research	2003	40
23	96-Well Plate Assays for Measuring Collagenase Activity Using 3H-Acetylated Collagen	Analytical Biochemistry	1999	37
24	Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation	Annals of the Rheumatic Diseases	2010	36
25	Processing of viable Salmonella typhimurium for presentation of a CD4 T cell epitope from the Salmonella invasion protein C (SipC)	European Journal of Immunology	2002	26
26	The route of bacterial uptake by macrophages influences the repertoire of epitopes presented to CD4 T cells	European Journal of Immunology	2002	26
27	MMP28 gene expression is regulated by Sp1 transcription factor acetylation	Biochemical Journal	2010	26
28	TGF-β1 and IFN-γ cross-regulate antigen presentation to CD4 T cells by macrophages	Journal of Leukocyte Biology	2002	26
29	TGF-beta1 and IFN-gamma cross-regulate antigen presentation to CD4 T cells by macrophages	Journal of Leukocyte Biology	2002	26
30	Serum MMP-1 and TIMP-1 levels are increased in patients with psoriatic arthritis and their siblings	British Journal of Rheumatology	2003	25
31	Influence of the severity of rheumatoid arthritis on sex differences in health assessment questionnaire scores.	Annals of the Rheumatic Diseases	1992	23
32	Linkage studies of hla and primary sjögren's syndrome in multicase families	Arthritis and Rheumatism	1993	22
33	Cartilage catabolism in arthritis: factors that influence homeostasis	Expert Reviews in Molecular Medicine	2001	13
34	Sialochemistry in juvenile idiopathic arthritis	Oral Diseases	2002	13
35	New developments in Sjogren’s syndrome	Rheumatology	2021	11
36	Self-report overestimates true height loss: implications for diagnosis of osteoporosis	Clinical Rheumatology	2005	10
37	Positive anti-MOG antibodies in a patient with Sjögren's syndrome and transverse myelitis	European Journal of Rheumatology	2019	10
38	Anti-Ro antibodies and complete heart block in adults with Sjögren’s syndrome	European Journal of Rheumatology	2018	10
39	A comparison of glycosaminoglycans content of human synovial fluid in different disease states	Biochemical Society Transactions	1984	5
40	Effect of rituximab or tumour necrosis factor inhibitors on lung infection and survival in rheumatoid arthritis-associated bronchiectasis	Rheumatology	2020	5
41	Nodular localized primary cutaneous amyloidosis and primary Sjögren’s syndrome	Scandinavian Journal of Rheumatology	2020	4
42	Prostate Cancer and Fracture: Identifying at-Risk Groups	Journal of Clinical Densitometry	2017	3
43	A limiting dilution assay to determine the frequency of antigen presenting cells	Journal of Immunological Methods	1987	2
44	Modified Larsen scoring of digitized radiographs in rheumatoid arthritis	Journal of Rheumatology	2003	2
45	Classification of rheumatoid arthritis: The importance of including data from the siblings	Genetic Epidemiology	1987	1
46	Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties	Arthritis Research and Therapy	2007	1
47	Rheumatology and Rheumatoid Arthritis in the Twenty-First Century	Seminars in Musculoskeletal Radiology	2012	1
48	OP0257 Differential DNA Methylation Related to Response to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis	Annals of the Rheumatic Diseases	2014	1
49	Gallium Uptake and Clinical Examination of Inflamed Diarthrodial Joints	Clinical Science	1980	0
50	Tolerogenic dendritic cells differentially modulate naïve and memory CD4+ T cells	Arthritis Research and Therapy	2007	0

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