| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 3 | Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention | Nature Reviews Gastroenterology and Hepatology | 2018 | 3,487 |
| 4 | Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors | Science | 2017 | 1,846 |
| 5 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 6 | IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy | Nature Genetics | 2009 | 1,808 |
| 7 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 8 | The Human Cell Atlas | ELife | 2017 | 1,547 |
| 9 | Single-cell reconstruction of the early maternal–fetal interface in humans | Nature | 2018 | 1,547 |
| 10 | Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis | Nature Reviews Gastroenterology and Hepatology | 2013 | 1,381 |
| 11 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 12 | Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial | Lancet, The | 2018 | 1,282 |
| 13 | Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 | Journal of Hepatology | 2018 | 1,157 |
| 14 | The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease | Cell | 2016 | 1,052 |
| 15 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 16 | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease | Nature Genetics | 2017 | 943 |
| 17 | Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol | Diabetologia | 2011 | 909 |
| 18 | From NASH to HCC: current concepts and future challenges | Nature Reviews Gastroenterology and Hepatology | 2019 | 872 |
| 19 | Human dendritic cell subsets: an update | Immunology | 2018 | 866 |
| 20 | Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients | Diabetes Care | 2007 | 864 |
| 21 | Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening | Gastroenterology | 2016 | 847 |
| 22 | Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management | Journal of Hepatology | 2015 | 840 |
| 23 | Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases | Gut | 2017 | 807 |
| 24 | European Respiratory Society guidelines for the management of adult bronchiectasis | European Respiratory Journal | 2017 | 788 |
| 25 | Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease | Gastroenterology | 2019 | 777 |
| 26 | Origins of lifetime health around the time of conception: causes and consequences | Lancet, The | 2018 | 771 |
| 27 | IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance | Trends in Immunology | 2016 | 767 |
| 28 | IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses | Immunity | 2013 | 703 |
| 29 | Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence | Nature Communications | 2012 | 693 |
| 30 | Cellular senescence drives age-dependent hepatic steatosis | Nature Communications | 2017 | 673 |
| 31 | Age Group Comparability of Raw Accelerometer Output from Wrist- and Hip-Worn Monitors | Medicine and Science in Sports and Exercise | 2014 | 659 |
| 32 | Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study | PLoS ONE | 2017 | 654 |
| 33 | Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells | Immunity | 2012 | 643 |
| 34 | Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers | Hepatology | 2008 | 625 |
| 35 | Nonalcoholic fatty liver disease | Nature Reviews Disease Primers | 2015 | 612 |
| 36 | Comparison of gene expression profiles between human and mouse monocyte subsets | Blood | 2010 | 609 |
| 37 | Updated Treatment Algorithm of Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2013 | 596 |
| 38 | Chronic inflammation induces telomere dysfunction and accelerates ageing in mice | Nature Communications | 2014 | 596 |
| 39 | Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells | Cell | 2016 | 573 |
| 40 | Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial | Lancet Diabetes and Endocrinology,the | 2019 | 569 |
| 41 | Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis | JAMA - Journal of the American Medical Association | 2014 | 566 |
| 42 | IRF8Mutations and Human Dendritic-Cell Immunodeficiency | New England Journal of Medicine | 2011 | 564 |
| 43 | Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease | Hepatology | 2010 | 563 |
| 44 | Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis | European Journal of Epidemiology | 2013 | 550 |
| 45 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
| 46 | Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage | Science | 2013 | 541 |
| 47 | Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial | Lancet Diabetes and Endocrinology,the | 2015 | 535 |
| 48 | Mitochondria are required for pro‐ageing features of the senescent phenotype | EMBO Journal | 2016 | 527 |
| 49 | Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis | American Journal of Gastroenterology | 2017 | 524 |
| 50 | Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial | Lancet, The | 2013 | 518 |
