| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 2 | Gut microbiota in the pathogenesis of inflammatory bowel disease | Clinical Journal of Gastroenterology | 2018 | 904 |
| 3 | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus | Nature Genetics | 2008 | 694 |
| 4 | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations | Nature Genetics | 2008 | 641 |
| 5 | Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney | Journal of Clinical Investigation | 2010 | 560 |
| 6 | Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease | Digestion | 2016 | 458 |
| 7 | SIRT1 and insulin resistance | Nature Reviews Endocrinology | 2009 | 312 |
| 8 | Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway | Diabetes | 2011 | 300 |
| 9 | Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease | Journal of Gastroenterology | 2018 | 296 |
| 10 | Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance | Lancet, The | 2009 | 272 |
| 11 | Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice | Science | 2020 | 255 |
| 12 | Association ofCDKAL1, IGF2BP2, CDKN2A/B, HHEX,SLC30A8,andKCNJ11With Susceptibility to Type 2 Diabetes in a Japanese Population | Diabetes | 2008 | 252 |
| 13 | A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B | Nature Genetics | 2010 | 245 |
| 14 | Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy | Diabetes | 2016 | 243 |
| 15 | Effects of Antioxidants in Diabetes-Induced Oxidative Stress in the Glomeruli of Diabetic Rats | Journal of the American Society of Nephrology: JASN | 2003 | 240 |
| 16 | Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease | Journal of Gastroenterology and Hepatology (Australia) | 2013 | 235 |
| 17 | Emerging role of autophagy in kidney function, diseases and aging | Autophagy | 2012 | 228 |
| 18 | Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis | Journal of Gastroenterology | 2010 | 224 |
| 19 | Diabetic neuropathy and nerve regeneration | Progress in Neurobiology | 2003 | 221 |
| 20 | Role of Altered Renal Lipid Metabolism in the Development of Renal Injury Induced by a High-Fat Diet | Journal of the American Society of Nephrology: JASN | 2007 | 220 |
| 21 | Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance | Cell | 2016 | 214 |
| 22 | Structural and functional changes in the kidneys of high-fat diet-induced obese mice | American Journal of Physiology - Renal Physiology | 2009 | 212 |
| 23 | SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation | Journal of Biological Chemistry | 2007 | 209 |
| 24 | Translocation of Glomerular p47phox and p67phox by Protein Kinase C- Activation Is Required for Oxidative Stress in Diabetic Nephropathy | Diabetes | 2003 | 199 |
| 25 | Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes | Molecular and Cellular Biology | 2004 | 199 |
| 26 | SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition | Cell Metabolism | 2020 | 197 |
| 27 | Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis | Journal of Gastroenterology | 2011 | 191 |
| 28 | Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy | Diabetes | 2005 | 189 |
| 29 | Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions | Journal of the American Society of Nephrology: JASN | 2013 | 185 |
| 30 | Factors Associated With Frequent Remission of Microalbuminuria in Patients With Type 2 Diabetes | Diabetes | 2005 | 182 |
| 31 | Epithelial overexpression of interleukin-32α in inflammatory bowel disease | Clinical and Experimental Immunology | 2007 | 180 |
| 32 | Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population | Journal of Clinical Biochemistry and Nutrition | 2016 | 171 |
| 33 | Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study | International Journal of Obesity | 2006 | 170 |
| 34 | Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India | Diabetes | 2013 | 167 |
| 35 | Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation | Free Radical Biology and Medicine | 2006 | 163 |
| 36 | Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes | American Journal of Human Genetics | 2004 | 160 |
| 37 | Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis | Gut | 2017 | 159 |
| 38 | Genome-wide association study identifies three novel loci for type 2 diabetes | Human Molecular Genetics | 2014 | 158 |
| 39 | Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease | Journal of Gastroenterology | 2012 | 152 |
| 40 | Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice | Biochemical and Biophysical Research Communications | 2006 | 150 |
| 41 | Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes | Nature Communications | 2016 | 149 |
| 42 | Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells | PLoS ONE | 2017 | 147 |
| 43 | Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis | Kidney International | 2011 | 145 |
| 44 | Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes | Diabetes | 2007 | 144 |
| 45 | Nutrient Sensing, Autophagy, and Diabetic Nephropathy | Diabetes | 2012 | 141 |
| 46 | Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model | Biochemical and Biophysical Research Communications | 2009 | 139 |
| 47 | Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis | Gastroenterology | 2018 | 139 |
| 48 | Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy | Diabetes Research and Clinical Practice | 2007 | 138 |
| 49 | Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems | Current Pharmaceutical Design | 2018 | 136 |
| 50 | Microbiome potentiates endurance exercise through intestinal acetate production | American Journal of Physiology - Endocrinology and Metabolism | 2019 | 131 |
