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Top Articles

#TitleJournalYearCitations
1A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future NeedsEnvironmental Health Perspectives2005587
2A cascade of cytokines mediates mechanical inflammatory hypernociception in miceProceedings of the National Academy of Sciences of the United States of America2005503
3Hypernociceptive role of cytokines and chemokines: Targets for analgesic drug development?2006454
4Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infectionNature Medicine2010413
5Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disordersPhilosophical Transactions of the Royal Society B: Biological Sciences2012319
6The Stressed CNS: When Glucocorticoids Aggravate InflammationNeuron2009317
7Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1AreceptorsBritish Journal of Pharmacology2010304
8Antianxiety effect of cannabidiol in the elevated plus-mazePsychopharmacology1990295
9Cannabidiol, neuroprotection and neuropsychiatric disordersPharmacological Research2016293
10Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent MannerCancer Research2018283
11Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical SepsisPLoS ONE2016282
12Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsisProceedings of the National Academy of Sciences of the United States of America2009278
13A Role for IL-18 in Neutrophil ActivationJournal of Immunology2001266
14Crucial role of neutrophils in the development of mechanical inflammatory hypernociceptionJournal of Leukocyte Biology2008260
15Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approachesFrontiers in Microbiology2015258
16Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trialsBMC Musculoskeletal Disorders2007249
17Low-Level Laser Therapy Induces Dose-Dependent Reduction of TNFα Levels in Acute InflammationPhotomedicine and Laser Surgery2006246
18The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide releaseEuropean Journal of Pharmacology1991242
19Bradykinin initiates cytokine‐mediated inflammatory hyperalgesiaBritish Journal of Pharmacology1993242
20Chronic Unpredictable Stress Exacerbates Lipopolysaccharide-Induced Activation of Nuclear Factor- B in the Frontal Cortex and Hippocampus via Glucocorticoid SecretionJournal of Neuroscience2006238
21IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapyAnnals of the Rheumatic Diseases2010228
22Commensal microbiota is fundamental for the development of inflammatory painProceedings of the National Academy of Sciences of the United States of America2008226
23The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid systemInternational Journal of Neuropsychopharmacology2013225
245‐HT1A receptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in ratsBritish Journal of Pharmacology2009218
25Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic DiseasesMediators of Inflammation2018199
26NEUTROPHIL PARALYSIS IN SEPSISShock2010195
27Behavioral Effects of Acute and Chronic Imipramine in the Elevated T-Maze Model of AnxietyPharmacology Biochemistry and Behavior2000187
28Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New AgeFrontiers in Immunology2018187
29Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trialRMD Open2021183
30Morphine peripheral analgesia depends on activation of the PI3Kγ/AKT/nNOS/NO/K ATP signaling pathwayProceedings of the National Academy of Sciences of the United States of America2010181
31Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's DiseaseJournal of Alzheimer's Disease2011179
32Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonistBritish Journal of Pharmacology2000173
33Effects of Low-Level Laser Therapy and Eccentric Exercises in the Treatment of Recreational Athletes with Chronic Achilles TendinopathyAmerican Journal of Sports Medicine2008170
34Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive ratsAtherosclerosis2008170
35Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive ratsClinical Science2012170
36Peripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathwayProceedings of the National Academy of Sciences of the United States of America2004168
37Anxiolytic-like effect of cannabidiol in the rat Vogel conflict testProgress in Neuro-Psychopharmacology and Biological Psychiatry2006168
38IL-33 mediates antigen-induced cutaneous and articular hypernociception in miceProceedings of the National Academy of Sciences of the United States of America2008168
39IL-17 Receptor Signaling Is Required to Control Polymicrobial SepsisJournal of Immunology2009168
40A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive ratsCardiovascular Research2004166
41Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effectsPsychopharmacology2006166
42Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in miceEuropean Journal of Pharmacology2005164
43Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-Like Tyrosine Kinase-1 and Soluble Endogline in PreeclampsiaHypertension2008161
44The Central Role of the Gut Microbiota in Chronic Inflammatory DiseasesJournal of Immunology Research2014158
45Acute Aerobic Exercise Increases Brain-Derived Neurotrophic Factor Levels in Elderly with Alzheimer's DiseaseJournal of Alzheimer's Disease2014157
46A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthmaNature Medicine2004156
47Effect of 655-nm Low-Level Laser Therapy on Exercise-Induced Skeletal Muscle Fatigue in HumansPhotomedicine and Laser Surgery2008152
48Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptorEuropean Journal of Pharmacology2012151
49Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairmentJournal of Neuroinflammation2014151
50Effect of low-level laser (Ga-Al-As 655 nm) on skeletal muscle fatigue induced by electrical stimulation in ratsJournal of Applied Physiology2006150