| # | Title | Journal | Year | Citations |
|---|
| 1 | Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele | Nature | 1996 | 3,776 |
| 2 | Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions | Nature Medicine | 2001 | 1,484 |
| 3 | uPAR: a versatile signalling orchestrator | Nature Reviews Molecular Cell Biology | 2002 | 1,140 |
| 4 | Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 | Nature Medicine | 2002 | 1,008 |
| 5 | Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration | Nature Genetics | 2001 | 967 |
| 6 | A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 703 |
| 7 | Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 | Nature Medicine | 2003 | 699 |
| 8 | Role of tissue factor in embryonic blood vessel development | Nature | 1996 | 646 |
| 9 | Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization | Nature Medicine | 1998 | 635 |
| 10 | Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation | Nature Genetics | 1997 | 621 |
| 11 | VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model | Nature | 2004 | 569 |
| 12 | Modification of kidney barrier function by the urokinase receptor | Nature Medicine | 2008 | 501 |
| 13 | VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection | BioEssays | 2004 | 476 |
| 14 | Blood vessels and nerves: common signals, pathways and diseases | Nature Reviews Genetics | 2003 | 456 |
| 15 | Identification of a new caspase homologue: caspase-14 | Cell Death and Differentiation | 1998 | 448 |
| 16 | Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis | Nature Genetics | 2004 | 410 |
| 17 | Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia | Nature Genetics | 2004 | 393 |
| 18 | Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 | Mechanisms of Development | 2002 | 390 |
| 19 | Syntenin, a PDZ protein that binds syndecan cytoplasmic domains | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 386 |
| 20 | Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival | Journal of Cell Biology | 2008 | 376 |
| 21 | Regulation of gene expression by alternative promoters | FASEB Journal | 1996 | 328 |
| 22 | Regulation of angiogenesis by tissue factor cytoplasmic domain signaling | Nature Medicine | 2004 | 326 |
| 23 | The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways | Journal of Experimental Medicine | 2002 | 325 |
| 24 | Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy | Nature Genetics | 2006 | 323 |
| 25 | Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders | Journal of Thrombosis and Haemostasis | 2003 | 312 |
| 26 | VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization | FASEB Journal | 2006 | 309 |
| 27 | The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin | Journal of Cell Biology | 2001 | 307 |
| 28 | Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas | Cancer Research | 1999 | 295 |
| 29 | VEGF: A modifier of the del22q11 (DiGeorge) syndrome? | Nature Medicine | 2003 | 288 |
| 30 | Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth | Circulation | 2004 | 273 |
| 31 | Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation Syndrome | American Journal of Human Genetics | 2003 | 272 |
| 32 | Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia | Journal of Clinical Investigation | 2003 | 267 |
| 33 | The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent | FASEB Journal | 2002 | 260 |
| 34 | Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality | Journal of Experimental Medicine | 2006 | 249 |
| 35 | Nanoparticles for the delivery of genes and drugs to human hepatocytes | Nature Biotechnology | 2003 | 245 |
| 36 | Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome | Nature Medicine | 2001 | 240 |
| 37 | Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders | Seminars in Cell and Developmental Biology | 2002 | 234 |
| 38 | Molecular Basis of Angiogenesis: Role of VEGF and VE‐Cadherin | Annals of the New York Academy of Sciences | 2000 | 233 |
| 39 | Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing | Cell Death and Differentiation | 2000 | 218 |
| 40 | The syndecans, tuners of transmembrane signaling | FASEB Journal | 1999 | 205 |
| 41 | Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation | Molecular and Cellular Biology | 2005 | 202 |
| 42 | Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation | Circulation | 1997 | 200 |
| 43 | VEGF: a critical player in neurodegeneration | Journal of Clinical Investigation | 2004 | 198 |
| 44 | Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 193 |
| 45 | Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans The GenBank accession number for the sequence reported in this paper is AF043230. | Microbiology (United Kingdom) | 2001 | 187 |
| 46 | Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 186 |
| 47 | Toxic effect of indocyanine green on retinal pigment epithelium related to osmotic effects of the solvent | American Journal of Ophthalmology | 2002 | 184 |
| 48 | Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils | Journal of Experimental Medicine | 2004 | 176 |
| 49 | Survivin splice variants regulate the balance between proliferation and cell death | Oncogene | 2005 | 176 |
| 50 | Differential contribution of the three Aph1 genes to γ-secretase activity in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 173 |
