| # | Title | Journal | Year | Citations |
|---|
| 1 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
| 2 | Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex | Science | 2005 | 5,761 |
| 3 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals | Nature Genetics | 2003 | 5,434 |
| 4 | Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs | Nature | 2005 | 4,435 |
| 5 | The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray) | Science | 2006 | 3,945 |
| 6 | Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals | Nature | 2009 | 3,801 |
| 7 | An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans | Science | 2001 | 3,041 |
| 8 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state | Nature | 2007 | 2,517 |
| 9 | MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS | Annual Review of Plant Biology | 2006 | 2,418 |
| 10 | Tumour invasion and metastasis initiated by microRNA-10b in breast cancer | Nature | 2007 | 2,382 |
| 11 | Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton | Current Biology | 2004 | 2,370 |
| 12 | The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 | Science | 2008 | 2,280 |
| 13 | I kappa B: a specific inhibitor of the NF-kappa B transcription factor | Science | 1988 | 2,240 |
| 14 | Creation of human tumour cells with defined genetic elements | Nature | 1999 | 2,148 |
| 15 | Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA | Molecular Cell | 2004 | 2,097 |
| 16 | Epigenetic memory in induced pluripotent stem cells | Nature | 2010 | 2,011 |
| 17 | Role for DNA methylation in genomic imprinting | Nature | 1993 | 2,001 |
| 18 | Tumor spectrum analysis in p53-mutant mice | Current Biology | 1994 | 1,903 |
| 19 | The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes | Nature | 2003 | 1,887 |
| 20 | HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation | Cell | 2003 | 1,862 |
| 21 | Oxidized redox state of glutathione in the endoplasmic reticulum | Science | 1992 | 1,797 |
| 22 | MicroRNAs in plants | Genes and Development | 2002 | 1,797 |
| 23 | Effects of an Rb mutation in the mouse | Nature | 1992 | 1,730 |
| 24 | Nonfilamentous C. albicans Mutants Are Avirulent | Cell | 1997 | 1,693 |
| 25 | hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization | Cell | 1997 | 1,689 |
| 26 | Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution | Cell Stem Cell | 2007 | 1,596 |
| 27 | Induction of Tumors in Mice by Genomic Hypomethylation | Science | 2003 | 1,393 |
| 28 | The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution | Science | 2005 | 1,382 |
| 29 | miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis | Nature Cell Biology | 2010 | 1,216 |
| 30 | Mechanisms of Viral Membrane Fusion and Its Inhibition | Annual Review of Biochemistry | 2001 | 1,209 |
| 31 | MicroRNAs Regulate Brain Morphogenesis in Zebrafish | Science | 2005 | 1,209 |
| 32 | A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana | Genes and Development | 2006 | 1,208 |
| 33 | HIV Entry and Its Inhibition | Cell | 1998 | 1,203 |
| 34 | Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS | Cell | 1992 | 1,202 |
| 35 | Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2020 | 1,195 |
| 36 | Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA–binding protein gene | Nature Genetics | 1995 | 1,183 |
| 37 | Criteria for Annotation of Plant MicroRNAs | Plant Cell | 2008 | 1,158 |
| 38 | The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen | Nature | 1984 | 1,107 |
| 39 | Demonstration that CFTR is a chloride channel by alteration of its anion selectivity | Science | 1991 | 1,103 |
| 40 | PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase | Molecular Cell | 2007 | 1,088 |
| 41 | Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation | Science | 2007 | 1,060 |
| 42 | The New Genomics: Global Views of Biology | Science | 1996 | 1,045 |
| 43 | Mice lacking brain-derived neurotrophic factor develop with sensory deficits | Nature | 1994 | 1,023 |
| 44 | mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway | Cell | 2011 | 1,002 |
| 45 | Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes | Cell | 2005 | 991 |
| 46 | Human Keratinocytes That Express hTERT and Also Bypass a p16 INK4a -Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics | Molecular and Cellular Biology | 2000 | 943 |
| 47 | A spring-loaded mechanism for the conformational change of influenza hemagglutinin | Cell | 1993 | 918 |
| 48 | Four Evolutionary Strata on the Human X Chromosome | Science | 1999 | 894 |
| 49 | GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR | Molecular Cell | 2003 | 883 |
| 50 | DNA hypomethylation leads to elevated mutation rates | Nature | 1998 | 859 |
