| # | Title | Journal | Year | Citations |
|---|
| 1 | Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase | Nature | 2005 | 4,382 |
| 2 | Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus | Cell | 2020 | 3,551 |
| 3 | The role of myeloid cells in the promotion of tumour angiogenesis | Nature Reviews Cancer | 2008 | 1,404 |
| 4 | A meta-analysis of previous fracture and subsequent fracture risk | Bone | 2004 | 1,052 |
| 5 | A systematic review of hip fracture incidence and probability of fracture worldwide | Osteoporosis International | 2012 | 1,048 |
| 6 | The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women | Osteoporosis International | 2007 | 1,017 |
| 7 | The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages | PLoS ONE | 2010 | 897 |
| 8 | Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues | Blood | 2004 | 772 |
| 9 | International Variations in Hip Fracture Probabilities: Implications for Risk Assessment | Journal of Bone and Mineral Research | 2002 | 511 |
| 10 | Alcohol intake as a risk factor for fracture | Osteoporosis International | 2005 | 473 |
| 11 | Interpretation and use of FRAX in clinical practice | Osteoporosis International | 2011 | 450 |
| 12 | Clodronate and Liposome-Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′-(β,γ-Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro | Journal of Bone and Mineral Research | 1997 | 388 |
| 13 | Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models | Nature Cell Biology | 2019 | 384 |
| 14 | Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review | Osteoporosis International | 2017 | 381 |
| 15 | Fracture risk following an osteoporotic fracture | Osteoporosis International | 2004 | 377 |
| 16 | Testosterone: a metabolic hormone in health and disease | Journal of Endocrinology | 2013 | 372 |
| 17 | Biomechanical factors in atherosclerosis: mechanisms and clinical implications | European Heart Journal | 2014 | 359 |
| 18 | Mitochondrial function and morphology are impaired in parkin‐mutant fibroblasts | Annals of Neurology | 2008 | 339 |
| 19 | Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. | Journal of Clinical Investigation | 1989 | 321 |
| 20 | Development and use of FRAX® in osteoporosis | Osteoporosis International | 2010 | 320 |
| 21 | Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis | | 1997 | 305 |
| 22 | Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche | Nature Communications | 2015 | 296 |
| 23 | Testosterone and obesity | Obesity Reviews | 2015 | 294 |
| 24 | Eating problems in adolescents with Type 1 diabetes: a systematic review with meta‐analysis | Diabetic Medicine | 2013 | 286 |
| 25 | Systematic Review of Trends in the Incidence Rates of Thyroid Cancer | Thyroid | 2016 | 286 |
| 26 | Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy | Coordination Chemistry Reviews | 2019 | 285 |
| 27 | Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis | Muscle and Nerve | 2002 | 281 |
| 28 | The variable incidence of hip fracture in Southern Europe: The MEDOS study | Osteoporosis International | 1994 | 266 |
| 29 | Neutrophils: key mediators of tumour angiogenesis | International Journal of Experimental Pathology | 2009 | 257 |
| 30 | Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2 | Neurology | 2010 | 257 |
| 31 | Excess mortality after hospitalisation for vertebral fracture | Osteoporosis International | 2004 | 250 |
| 32 | Guidance for the adjustment of FRAX according to the dose of glucocorticoids | Osteoporosis International | 2011 | 248 |
| 33 | Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis | Journal of Bone and Mineral Research | 1997 | 247 |
| 34 | Overview of bisphosphonates | | 1997 | 243 |
| 35 | A high incidence of vertebral fracture in women with breast cancer | British Journal of Cancer | 1999 | 243 |
| 36 | Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026] | Breast Cancer Research | 2006 | 243 |
| 37 | SCOPE 2021: a new scorecard for osteoporosis in Europe | Archives of Osteoporosis | 2021 | 233 |
| 38 | Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells | Nucleic Acids Research | 2004 | 230 |
| 39 | Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles | Neurobiology of Disease | 2015 | 219 |
| 40 | Testosterone: a vascular hormone in health and disease | Journal of Endocrinology | 2013 | 217 |
| 41 | Tumor-associated macrophages: Effectors of angiogenesis and tumor progression | Biochimica Et Biophysica Acta: Reviews on Cancer | 2009 | 212 |
| 42 | Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodies | Acta Neuropathologica | 2010 | 206 |
| 43 | Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells | Cancer Research | 2002 | 203 |
| 44 | The in vitro antibacterial activity of Turkish medicinal plants | Journal of Ethnopharmacology | 1999 | 190 |
| 45 | Making sense of big data in health research: Towards an EU action plan | Genome Medicine | 2016 | 190 |
| 46 | Epigenetics in Prostate Cancer: Biologic and Clinical Relevance | European Urology | 2011 | 187 |
| 47 | Nutritional Status and Nutritional Treatment Are Related to Outcomes and Mortality in Older Adults with Hip Fracture | Nutrients | 2018 | 186 |
| 48 | Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis | Glia | 2005 | 185 |
| 49 | Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair | Nucleic Acids Research | 2006 | 182 |
| 50 | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway | Cancer Research | 1998 | 182 |
