| # | Title | Journal | Year | Citations |
|---|
| 1 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 4,561 |
| 2 | The comet assay: topical issues | Mutagenesis | 2008 | 811 |
| 3 | Adenosine in the central nervous system: release mechanisms and extracellular concentrations | Journal of Neurochemistry | 2008 | 677 |
| 4 | Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies | Medicinal Research Reviews | 2010 | 431 |
| 5 | Role of Nitric Oxide in Angiogenesis and Tumor Progression in Head and Neck Cancer | Journal of the National Cancer Institute | 1998 | 404 |
| 6 | Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆ | Journal of Nutritional Biochemistry | 2010 | 393 |
| 7 | Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium | Journal of Biological Chemistry | 1998 | 392 |
| 8 | Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy | Circulation | 2013 | 347 |
| 9 | Pharmacological Strategies for Overcoming Multidrug Resistance | Current Drug Targets | 2006 | 335 |
| 10 | Adenosine decreases aspartate and glutamate release from rat hippocampal slices | European Journal of Pharmacology | 1984 | 334 |
| 11 | Pharmacokinetic Drug Interactions of Macrolides | Clinical Pharmacokinetics | 1992 | 322 |
| 12 | Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model | Journal of Agricultural and Food Chemistry | 2009 | 294 |
| 13 | Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites | European Journal of Pharmacology | 1999 | 282 |
| 14 | Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1 | European Journal of Pharmacology | 1999 | 280 |
| 15 | Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells | Microvascular Research | 1990 | 268 |
| 16 | Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation | Pain | 2011 | 264 |
| 17 | Presence of Kynurenic Acid in the Mammalian Brain | Journal of Neurochemistry | 1988 | 258 |
| 18 | Effects of novelty and habituation on acetylcholine, GABA, and glutamate release from the frontal cortex and hippocampus of freely moving rats | Neuroscience | 2001 | 241 |
| 19 | Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation | Progress in Neurobiology | 2007 | 232 |
| 20 | ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia | Neurochemistry International | 2005 | 227 |
| 21 | Curcumin, a golden spice with a low bioavailability | Journal of Herbal Medicine | 2015 | 224 |
| 22 | A role for superoxide in gentamicin-mediated nephropathy in rats | European Journal of Pharmacology | 2002 | 216 |
| 23 | Changes in cortical acetylcholine output induced by modulation of the nucleus basalis | Brain Research Bulletin | 1986 | 213 |
| 24 | Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo | Journal of Medicinal Chemistry | 2012 | 211 |
| 25 | Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium | American Journal of Physiology - Heart and Circulatory Physiology | 1996 | 205 |
| 26 | High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo | Journal of Neurochemistry | 2007 | 204 |
| 27 | Presynaptic kynurenate-sensitive receptors inhibit glutamate release | European Journal of Neuroscience | 2001 | 203 |
| 28 | Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation | PLoS ONE | 2012 | 194 |
| 29 | TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism | Pflugers Archiv European Journal of Physiology | 2012 | 190 |
| 30 | Cholinesterase Inhibitors and Beyond | Current Alzheimer Research | 2009 | 181 |
| 31 | Induction of Inflammatory Mediators and Microglial Activation in Mice Transgenic for Mutant Human P301S Tau Protein | American Journal of Pathology | 2004 | 180 |
| 32 | Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions | Pharmacology Biochemistry and Behavior | 1996 | 170 |
| 33 | Differential effects of amyloid peptides β-(1–40) and β-(25–35) injections into the rat nucleus basalis | Neuroscience | 1995 | 169 |
| 34 | Platelets and inflammation: Role of platelet-derived growth factor, adhesion molecules and histamine | Inflammation Research | 1997 | 166 |
| 35 | The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension | Trends in Pharmacological Sciences | 2005 | 166 |
| 36 | NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study | Journal of Neuroscience | 1994 | 165 |
| 37 | The ‘headache tree’ via umbellulone and TRPA1 activates the trigeminovascular system | Brain | 2012 | 163 |
| 38 | Inhibition of Nicotinamide Phosphoribosyltransferase | Journal of Biological Chemistry | 2010 | 162 |
| 39 | Chemistry and mode of action of macrolides | Journal of Antimicrobial Chemotherapy | 1993 | 160 |
| 40 | Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities | Neuroscience | 1994 | 153 |
| 41 | Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women | British Journal of Nutrition | 2006 | 153 |
| 42 | Clinical Pharmacokinetics of Depot Leuprorelin | Clinical Pharmacokinetics | 2002 | 151 |
| 43 | Long-term ethanol consumption by rats: Effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior | Neuroscience | 1993 | 150 |
| 44 | Kynurenine Hydroxylase Inhibitors Reduce Ischemic Brain Damage: Studies with (m-Nitrobenzoyl)-Alanine (mNBA) and 3,4-Dimethoxy-[-N-4-(Nitrophenyl)Thiazol-2YL]-Benzenesulfonamide (Ro 61-8048) in Models of Focal or Global Brain Ischemia | Journal of Cerebral Blood Flow and Metabolism | 1999 | 150 |
| 45 | A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology | Journal of Enzyme Inhibition and Medicinal Chemistry | 2012 | 150 |
| 46 | Adverse Effects of Macrolide Antibacterials | Drug Safety | 1993 | 147 |
| 47 | CELL BIOLOGY: PARP-1--a Perpetrator of Apoptotic Cell Death? | Science | 2002 | 146 |
| 48 | Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer | American Journal of Pathology | 2003 | 146 |
| 49 | Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1 | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 146 |
| 50 | Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease | Journal of Neurochemistry | 2010 | 146 |
