| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | TFOS DEWS II Definition and Classification Report | Ocular Surface | 2017 | 1,932 |
| 4 | Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche | Cell | 2004 | 1,753 |
| 5 | Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein | Journal of Biological Chemistry | 2004 | 1,397 |
| 6 | Microglia-specific localisation of a novel calcium binding protein, Iba1 | Molecular Brain Research | 1998 | 1,228 |
| 7 | Gastroduodenal Disorders | Gastroenterology | 2016 | 1,088 |
| 8 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth | Cancer Cell | 2011 | 1,020 |
| 9 | Operative Results and Postoperative Progression of Ossification Among Patients With Ossification of Cervical Posterior Longitudinal Ligament | Spine | 1981 | 916 |
| 10 | Metabolic requirements for the maintenance of self-renewing stem cells | Nature Reviews Molecular Cell Biology | 2014 | 848 |
| 11 | Variation in the safety of induced pluripotent stem cell lines | Nature Biotechnology | 2009 | 811 |
| 12 | Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2019 | 767 |
| 13 | Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury | Nature Medicine | 2009 | 754 |
| 14 | Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis | Gastroenterology | 2014 | 753 |
| 15 | Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials | Spinal Cord | 2007 | 748 |
| 16 | Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial | Lancet, The | 2018 | 706 |
| 17 | Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche | Cell Stem Cell | 2007 | 686 |
| 18 | Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis | Cell Metabolism | 2006 | 681 |
| 19 | Expansive Open-Door Laminoplasty for Cervical Spinal Stenotic Myelopathy | Spine | 1983 | 677 |
| 20 | Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma | Cell Reports | 2016 | 671 |
| 21 | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations | Nature Genetics | 2008 | 641 |
| 22 | Differential Metabolomics Reveals Ophthalmic Acid as an Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption* | Journal of Biological Chemistry | 2006 | 640 |
| 23 | Osteoclast–osteoblast communication | Archives of Biochemistry and Biophysics | 2008 | 618 |
| 24 | Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model | Biomaterials | 2004 | 602 |
| 25 | A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆ | Gastroenterology | 2004 | 600 |
| 26 | IFCC Reference System for Measurement of Hemoglobin A1c in Human Blood and the National Standardization Schemes in the United States, Japan, and Sweden: A Method-Comparison Study | Clinical Chemistry | 2004 | 587 |
| 27 | Efficacy and safety of recombinant human soluble thrombomodulin (ART‐123) in disseminated intravascular coagulation: results of a phase III, randomized, double‐blind clinical trial | Journal of Thrombosis and Haemostasis | 2007 | 534 |
| 28 | The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer | Journal of Thoracic Oncology | 2016 | 530 |
| 29 | Modeling familial Alzheimer's disease with induced pluripotent stem cells | Human Molecular Genetics | 2011 | 527 |
| 30 | Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain | Stroke | 2001 | 515 |
| 31 | Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos | Journal of Biological Chemistry | 2004 | 509 |
| 32 | v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation | Nature Medicine | 2006 | 502 |
| 33 | Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 489 |
| 34 | Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor | Nature | 1996 | 486 |
| 35 | Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 473 |
| 36 | ADAMs in cancer cell proliferation and progression | Cancer Science | 2007 | 472 |
| 37 | THE REGIONAL AND SUBCELLULAR DISTRIBUTION OF 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE IN THE CENTRAL NERVOUS SYSTEM | Journal of Neurochemistry | 1967 | 454 |
| 38 | Lack of common NOD2 variants in Japanese patients with Crohn's disease | Gastroenterology | 2002 | 449 |
| 39 | Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction | Journal of Molecular and Cellular Cardiology | 2013 | 447 |
| 40 | Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: A Japanese Gynecologic Oncology Group study | Gynecologic Oncology | 2008 | 431 |
| 41 | External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers | Journal of Experimental Medicine | 2009 | 429 |
| 42 | Vegetarian Diets and Blood Pressure | JAMA Internal Medicine | 2014 | 417 |
| 43 | Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures | Spinal Cord | 2007 | 403 |
| 44 | A novel difficulty scoring system for laparoscopic liver resection | Journal of Hepato-Biliary-Pancreatic Sciences | 2014 | 403 |
| 45 | High-Frequency Generation of Transgenic Zebrafish Which Reliably Express GFP in Whole Muscles or the Whole Body by Using Promoters of Zebrafish Origin | Developmental Biology | 1997 | 400 |
| 46 | Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin | Nature | 1993 | 396 |
| 47 | Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1 | Esophagus | 2019 | 394 |
| 48 | Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society | Esophagus | 2015 | 383 |
| 49 | Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 382 |
| 50 | Long-Term Outcomes of Standard Discectomy for Lumbar Disc Herniation | Spine | 2001 | 376 |
