| # | Title | Journal | Year | Citations |
|---|
| 1 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling | Nature | 2000 | 8,977 |
| 2 | Life with 6000 Genes | Science | 1996 | 3,548 |
| 3 | Exploring the new world of the genome with DNA microarrays | Nature Genetics | 1999 | 2,189 |
| 4 | The Genetic Landscape of a Cell | Science | 2010 | 1,937 |
| 5 | Single myosin molecule mechanics: piconewton forces and nanometre steps | Nature | 1994 | 1,861 |
| 6 | Structural Basis for Gluten Intolerance in Celiac Sprue | Science | 2002 | 1,383 |
| 7 | A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization. | Genome Research | 1996 | 946 |
| 8 | Inorganic Polyphosphate: A Molecule of Many Functions | Annual Review of Biochemistry | 1999 | 937 |
| 9 | Gene Expression During the Life Cycle of Drosophila melanogaster | Science | 2002 | 843 |
| 10 | Integration of murine leukemia virus DNA depends on mitosis. | EMBO Journal | 1993 | 824 |
| 11 | Duplex opening by dnaA protein at novel sequences in initiation of replication at the origin of the E. coli chromosome | Cell | 1988 | 726 |
| 12 | Comparative Gene Expression Profiles Following UV Exposure in Wild-Type and SOS-Deficient Escherichia coli | Genetics | 2001 | 721 |
| 13 | sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways | Cell | 1998 | 708 |
| 14 | Rain-, wind-, and touch-induced expression of calmodulin and calmodulin-related genes in Arabidopsis | Cell | 1990 | 698 |
| 15 | A Single-Molecule Study of RNA Catalysis and Folding | Science | 2000 | 696 |
| 16 | Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli | Science | 2001 | 687 |
| 17 | Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed | Molecular and Cellular Biology | 1983 | 674 |
| 18 | Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association | Nature Genetics | 2001 | 642 |
| 19 | NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A | Nature | 1988 | 633 |
| 20 | RNA Chaperones and the RNA Folding Problem | Journal of Biological Chemistry | 1995 | 632 |
| 21 | Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 632 |
| 22 | ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein | Cell | 1991 | 622 |
| 23 | Tube Morphogenesis | Cell | 2003 | 618 |
| 24 | An algorithm for finding protein–DNA binding sites with applications to chromatin- immunoprecipitation microarray experiments | Nature Biotechnology | 2002 | 617 |
| 25 | A high-resolution map of transcription in the yeast genome | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 613 |
| 26 | DNA Ligase: Structure, Mechanism, and Function | Science | 1974 | 603 |
| 27 | Systematic Analysis of Breast Cancer Morphology Uncovers Stromal Features Associated with Survival | Science Translational Medicine | 2011 | 603 |
| 28 | branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching | Cell | 1996 | 586 |
| 29 | A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast | Nature | 1989 | 574 |
| 30 | Helix propensities of the amino acids measured in alanine‐based peptides without helix‐stabilizing side‐chain interactions | Protein Science | 1994 | 572 |
| 31 | The rate of bulk flow from the endoplasmic reticulum to the cell surface | Cell | 1987 | 563 |
| 32 | Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms | Cell | 1993 | 555 |
| 33 | Inorganic polyphosphate: toward making a forgotten polymer unforgettable | Journal of Bacteriology | 1995 | 552 |
| 34 | In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses | Journal of Virology | 2008 | 546 |
| 35 | Genomic profiling of drug sensitivities via induced haploinsufficiency | Nature Genetics | 1999 | 533 |
| 36 | Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 531 |
| 37 | Bacterial Chromosomal Loci Move Subdiffusively through a Viscoelastic Cytoplasm | Physical Review Letters | 2010 | 527 |
| 38 | Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1 | Science | 1992 | 526 |
| 39 | Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water | Biopolymers | 1991 | 515 |
| 40 | Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 504 |
| 41 | Involvement of GTP-binding “G” proteins in transport through the Golgi stack | Cell | 1987 | 503 |
| 42 | A model for initiation at origins of DNA replication | Cell | 1988 | 490 |
| 43 | The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. | Genes and Development | 1990 | 485 |
| 44 | Relative helix-forming tendencies of nonpolar amino acids | Nature | 1990 | 479 |
| 45 | Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer | Genes Chromosomes and Cancer | 2006 | 464 |
| 46 | How molecular motors work | Nature | 1994 | 451 |
| 47 | The golgi apparatus: two organelles in tandem | Science | 1981 | 449 |
| 48 | The Hypoxic Response: Huffing and HIFing | Cell | 1997 | 446 |
| 49 | Synergism between morphogenetic mutants of Myxococcus xanthus | Developmental Biology | 1978 | 442 |
| 50 | Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches | Cell | 2007 | 437 |
