| # | Title | Journal | Year | Citations |
|---|
| 1 | Cascade Reactions in Total Synthesis | Angewandte Chemie - International Edition | 2006 | 1,939 |
| 2 | Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates | Journal of the American Chemical Society | 2005 | 1,497 |
| 3 | Efficiency and Fidelity in a Click-Chemistry Route to Triazole Dendrimers by the Copper(I)-Catalyzed Ligation of Azides and Alkynes | Angewandte Chemie - International Edition | 2004 | 1,089 |
| 4 | The antiquity of RNA-based evolution | Nature | 2002 | 914 |
| 5 | A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron | Nature | 2004 | 912 |
| 6 | Analysis and Optimization of Copper‐Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation | Angewandte Chemie - International Edition | 2009 | 856 |
| 7 | Organic Synthesis on Soluble Polymer Supports: Liquid-Phase Methodologies | Chemical Reviews | 1997 | 623 |
| 8 | Addition of a photocrosslinking amino acid to the genetic code of Escherichia coli | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 617 |
| 9 | Expanding the Genetic Code | Angewandte Chemie - International Edition | 2005 | 583 |
| 10 | Direct Human Cartilage Repair Using Three-Dimensional Bioprinting Technology | Tissue Engineering - Part A | 2012 | 575 |
| 11 | Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis | Chemical Communications | 2003 | 571 |
| 12 | Chasing Molecules That Were Never There: Misassigned Natural Products and the Role of Chemical Synthesis in Modern Structure Elucidation | Angewandte Chemie - International Edition | 2005 | 556 |
| 13 | An Enhanced System for Unnatural Amino Acid Mutagenesis in E. coli | Journal of Molecular Biology | 2010 | 551 |
| 14 | Soluble Polymers as Scaffolds for Recoverable Catalysts and Reagents | Chemical Reviews | 2002 | 543 |
| 15 | Selectfluor: Mechanistic Insight and Applications | Angewandte Chemie - International Edition | 2005 | 536 |
| 16 | Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond | Journal of Pharmacy and Pharmaceutical Sciences | 2008 | 525 |
| 17 | EXPANDING THE GENETIC CODE | Annual Review of Biophysics and Biomolecular Structure | 2006 | 520 |
| 18 | A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity | Journal of the American Chemical Society | 2001 | 512 |
| 19 | Directed Evolution of Nucleic Acid Enzymes | Annual Review of Biochemistry | 2004 | 476 |
| 20 | Inhibitors of HIV-1 Protease by Using In Situ Click Chemistry | Angewandte Chemie - International Edition | 2006 | 469 |
| 21 | Iodine(V) Reagents in Organic Synthesis. Part 4.o-Iodoxybenzoic Acid as a Chemospecific Tool for Single Electron Transfer-Based Oxidation Processes | Journal of the American Chemical Society | 2002 | 420 |
| 22 | Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions | Journal of the American Chemical Society | 1999 | 381 |
| 23 | Adding Amino Acids with Novel Reactivity to the Genetic Code of Saccharomyces Cerevisiae | Journal of the American Chemical Society | 2003 | 371 |
| 24 | A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR | Molecular Cell | 2003 | 359 |
| 25 | Sulfotransferases: Structure, Mechanism, Biological Activity, Inhibition, and Synthetic Utility | Angewandte Chemie - International Edition | 2004 | 353 |
| 26 | Discovery and Characterization of Catalysts for Azide−Alkyne Cycloaddition by Fluorescence Quenching | Journal of the American Chemical Society | 2004 | 353 |
| 27 | Sulfatases: Structure, Mechanism, Biological Activity, Inhibition, and Synthetic Utility | Angewandte Chemie - International Edition | 2004 | 338 |
| 28 | Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases | Cell | 2008 | 332 |
| 29 | A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide | Angewandte Chemie - International Edition | 2005 | 331 |
| 30 | One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from In Situ Generated Azides | Organic Letters | 2004 | 329 |
| 31 | Mechanisms of in Situ Activation for DNA-Targeting Antitumor Agents | Chemical Reviews | 2002 | 328 |
| 32 | Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 323 |
| 33 | Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 321 |
| 34 | Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 320 |
| 35 | In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors | Journal of the American Chemical Society | 2005 | 318 |
| 36 | Dedifferentiation of Lineage-Committed Cells by a Small Molecule | Journal of the American Chemical Society | 2004 | 308 |
| 37 | Bromine-Catalyzed Aziridination of Olefins. A Rare Example of Atom-Transfer Redox Catalysis by a Main Group Element | Journal of the American Chemical Society | 1998 | 307 |
| 38 | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 302 |
| 39 | Construction of Linear Polymers, Dendrimers, Networks, and Other Polymeric Architectures by Copper‐Catalyzed Azide‐Alkyne Cycloaddition “Click” Chemistry | Macromolecular Rapid Communications | 2008 | 302 |
| 40 | Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 301 |
| 41 | Soluble Polymer-Supported Organic Synthesis | Accounts of Chemical Research | 2000 | 299 |
| 42 | The folding mechanism of a β-sheet: the WW domain | Journal of Molecular Biology | 2001 | 297 |
| 43 | Tailored Ligand Acceleration of the Cu-Catalyzed Azide−Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications | Journal of the American Chemical Society | 2010 | 291 |
| 44 | Accelerated Bioorthogonal Conjugation: A Practical Method for the Ligation of Diverse Functional Molecules to a Polyvalent Virus Scaffold | Bioconjugate Chemistry | 2005 | 287 |
| 45 | Click chemistry: function follows form | Chemical Society Reviews | 2010 | 284 |
| 46 | An Intramolecular [2 + 3] Cycloaddition Route to Fused 5-Heterosubstituted Tetrazoles | Organic Letters | 2001 | 281 |
| 47 | The Chemistry of Amine−Azide Interconversion: Catalytic Diazotransfer and Regioselective Azide Reduction | Journal of the American Chemical Society | 2002 | 276 |
| 48 | Towards Organo-Click Chemistry: Development of Organocatalytic Multicomponent Reactions Through Combinations of Aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen Cycloaddition Reactions | Chemistry - A European Journal | 2004 | 267 |
| 49 | A Genetically Encoded Fluorescent Amino Acid | Journal of the American Chemical Society | 2006 | 267 |
| 50 | The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug | Journal of Molecular Biology | 2012 | 267 |
