| # | Title | Journal | Year | Citations |
|---|
| 1 | Regulated portals of entry into the cell | Nature | 2003 | 3,355 |
| 2 | High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor | Science | 2007 | 3,112 |
| 3 | A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics | Analytical Chemistry | 2004 | 2,280 |
| 4 | ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures | Cell | 2003 | 2,180 |
| 5 | RING Domain E3 Ubiquitin Ligases | Annual Review of Biochemistry | 2009 | 2,180 |
| 6 | Adapting Proteostasis for Disease Intervention | Science | 2008 | 2,104 |
| 7 | Wnt proteins are lipid-modified and can act as stem cell growth factors | Nature | 2003 | 2,006 |
| 8 | Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides | Nature | 1996 | 1,933 |
| 9 | Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | Science | 2009 | 1,788 |
| 10 | The Gap Junction Communication Channel | Cell | 1996 | 1,765 |
| 11 | Matrix metalloproteinases and tumor metastasis | Cancer and Metastasis Reviews | 2006 | 1,712 |
| 12 | Robust single-particle tracking in live-cell time-lapse sequences | Nature Methods | 2008 | 1,658 |
| 13 | Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin | Neuron | 2004 | 1,599 |
| 14 | Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock | Science | 2000 | 1,539 |
| 15 | A mechanosensory complex that mediates the endothelial cell response to fluid shear stress | Nature | 2005 | 1,457 |
| 16 | The Way Things Move: Looking Under the Hood of Molecular Motor Proteins | Science | 2000 | 1,387 |
| 17 | Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins | Science | 1995 | 1,296 |
| 18 | A proteomic view of the Plasmodium falciparum life cycle | Nature | 2002 | 1,184 |
| 19 | Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. | Journal of Cell Biology | 1994 | 1,136 |
| 20 | A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2 | Cell | 1997 | 1,125 |
| 21 | Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5 | Science | 1997 | 1,120 |
| 22 | Phylogenetic Relationships within Cation Transporter Families of Arabidopsis | Plant Physiology | 2001 | 1,110 |
| 23 | Talin Binding to Integrin Tails: A Final Common Step in Integrin Activation | Science | 2003 | 1,079 |
| 24 | Time zones: a comparative genetics of circadian clocks | Nature Reviews Genetics | 2001 | 1,036 |
| 25 | Spiroindolones, a Potent Compound Class for the Treatment of Malaria | Science | 2010 | 1,031 |
| 26 | Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines | Nature | 2007 | 1,018 |
| 27 | Monocyte chemoattractant protein 1 in obesity and insulin resistance | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,000 |
| 28 | Activity-based protein profiling: The serine hydrolases | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 981 |
| 29 | Functional amyloid – from bacteria to humans | Trends in Biochemical Sciences | 2007 | 953 |
| 30 | Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis | Science | 1996 | 936 |
| 31 | Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome | Science | 2002 | 919 |
| 32 | A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron | Nature | 2004 | 912 |
| 33 | A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock | Neuron | 2004 | 909 |
| 34 | Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells | Current Biology | 1998 | 898 |
| 35 | Coordination of Rho GTPase activities during cell protrusion | Nature | 2009 | 898 |
| 36 | A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor | Structure | 2008 | 892 |
| 37 | The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore | Cell | 2006 | 887 |
| 38 | Nociceptors: the sensors of the pain pathway | Journal of Clinical Investigation | 2010 | 881 |
| 39 | Circadian rhythms from flies to human | Nature | 2002 | 860 |
| 40 | Piezo proteins are pore-forming subunits of mechanically activated channels | Nature | 2012 | 848 |
| 41 | A Heat-Sensitive TRP Channel Expressed in Keratinocytes | Science | 2002 | 828 |
| 42 | Conserved microtubule–actin interactions in cell movement and morphogenesis | Nature Cell Biology | 2003 | 794 |
| 43 | TRPM8 Is Required for Cold Sensation in Mice | Neuron | 2007 | 777 |
| 44 | Cloning of the Arabidopsis Clock Gene TOC1, an Autoregulatory Response Regulator Homolog | Science | 2000 | 772 |
| 45 | Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals | Nature | 1995 | 756 |
| 46 | Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding | Nature | 1995 | 756 |
| 47 | CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING:An Integrated Process | Annual Review of Biochemistry | 1997 | 745 |
| 48 | A structural change in the kinesin motor protein that drives motility | Nature | 1999 | 745 |
| 49 | A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses | Science | 2005 | 743 |
| 50 | Spatiotemporal dynamics of RhoA activity in migrating cells | Nature | 2006 | 734 |
