| The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? | Blood | 2006 | 625 |
| Immunobiology and pathogenesis of viral hepatitis | Annual Review of Pathology: Mechanisms of Disease | 2006 | 544 |
| Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes | Journal of Biological Chemistry | 2006 | 439 |
| Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake | Journal of Clinical Investigation | 2006 | 406 |
| Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 363 |
| Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells | Nature Structural and Molecular Biology | 2006 | 353 |
| Cancer-specific mutations in PIK3CA are oncogenic in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 348 |
| Sweet spots in functional glycomics | Nature Chemical Biology | 2006 | 327 |
| UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity | EMBO Journal | 2006 | 304 |
| Enamine-based aldol organocatalysis in water: are they really "all wet"? | Angewandte Chemie - International Edition | 2006 | 266 |
| Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization | Nature Chemical Biology | 2006 | 263 |
| Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system | Neurobiology of Disease | 2006 | 262 |
| Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6 | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 253 |
| Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 245 |
| TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism | Science | 2006 | 240 |
| Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death | Investigative Ophthalmology and Visual Science | 2006 | 235 |
| Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage | Nature Medicine | 2006 | 222 |
| Persistent hepatitis C virus infection in vitro: coevolution of virus and host | Journal of Virology | 2006 | 218 |
| A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis | Nature Medicine | 2006 | 210 |
| GroEL-GroES-mediated protein folding | Chemical Reviews | 2006 | 205 |
| Stroke and neurovascular protection | New England Journal of Medicine | 2006 | 193 |
| The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase | Journal of Biological Chemistry | 2006 | 191 |
| Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis | Amyloid: the International Journal of Experimental and Clinical Investigation: the Official Journal of the International Society of Amyloidosis | 2006 | 191 |
| Integrin-matrix interactions in the cerebral microvasculature | Arteriosclerosis, Thrombosis, and Vascular Biology | 2006 | 181 |
| Vaccination against weight gain | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 175 |
