# | Title | Journal | Year | Citations |
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1 | Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death | Nature | 2005 | 2,005 |
2 | NADPH Oxidase: An Update | Blood | 1999 | 1,986 |
3 | Hepatitis B Virus Immunopathogenesis | Annual Review of Immunology | 1995 | 1,550 |
4 | Platelets in atherothrombosis | Nature Medicine | 2002 | 1,426 |
5 | Contribution of platelets to tumour metastasis | Nature Reviews Cancer | 2011 | 1,325 |
6 | PROACT: A Phase II Randomized Trial of Recombinant Pro-Urokinase by Direct Arterial Delivery in Acute Middle Cerebral Artery Stroke | Stroke | 1998 | 1,184 |
7 | Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection | Science | 1999 | 1,144 |
8 | Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection | Journal of Experimental Medicine | 2001 | 1,091 |
9 | Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor | Cell | 1996 | 1,085 |
10 | Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes | Immunity | 1996 | 1,065 |
11 | Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke | Annals of Neurology | 1992 | 970 |
12 | Phagocytes and oxidative stress | American Journal of Medicine | 2000 | 912 |
13 | Identification of direct residue contacts in protein–protein interaction by message passing | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 902 |
14 | NONCYTOLYTICCONTROL OFVIRALINFECTIONS BY THEINNATE ANDADAPTIVEIMMUNERESPONSE | Annual Review of Immunology | 2001 | 896 |
15 | CD8 + T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection | Journal of Virology | 2003 | 879 |
16 | dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs | Human Mutation | 2016 | 845 |
17 | Penetrance of 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA | Lancet, The | 2002 | 807 |
18 | The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response | Nature Medicine | 1996 | 804 |
19 | Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism? | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 804 |
20 | AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs | Cell | 2001 | 803 |
21 | The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? | Blood | 2006 | 781 |
22 | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 757 |
23 | Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow | Cell | 1998 | 743 |
24 | Mammalian Microsomal Cytochrome P450 Monooxygenase | Molecular Cell | 2000 | 738 |
25 | NADPH oxidase | Current Opinion in Immunology | 2004 | 719 |
26 | Two-component and phosphorelay signal transduction | Current Opinion in Microbiology | 2000 | 710 |
27 | Oncogenic PI3K deregulates transcription and translation | Nature Reviews Cancer | 2005 | 708 |
28 | Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. | Stroke | 1991 | 703 |
29 | Expression of galectin-3 modulates T-cell growth and apoptosis. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 689 |
30 | IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS | Annual Review of Pathology: Mechanisms of Disease | 2006 | 669 |
31 | Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 | Science | 1991 | 661 |
32 | Proteome-wide covalent ligand discovery in native biological systems | Nature | 2016 | 651 |
33 | NADPH oxidase: an update | Blood | 1999 | 647 |
34 | Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants | Science | 2011 | 635 |
35 | Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 634 |
36 | Adhesion Mechanisms in Platelet Function | Circulation Research | 2007 | 617 |
37 | High-level hepatitis B virus replication in transgenic mice | Journal of Virology | 1995 | 599 |
38 | Genomic analysis of the host response to hepatitis B virus infection | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 598 |
39 | Inhibition of hepatitis B virus in mice by RNA interference | Nature Biotechnology | 2003 | 595 |
40 | Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 582 |
41 | Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 581 |
42 | Cerebral Microvessel Responses to Focal Ischemia | Journal of Cerebral Blood Flow and Metabolism | 2003 | 576 |
43 | Direct Human Cartilage Repair Using Three-Dimensional Bioprinting Technology | Tissue Engineering - Part A | 2012 | 575 |
44 | Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94 | Journal of Cerebral Blood Flow and Metabolism | 2000 | 574 |
45 | Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells | Nature | 1994 | 572 |
46 | Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination | Nature | 2015 | 571 |
47 | Common vs. rare allele hypotheses for complex diseases | Current Opinion in Genetics and Development | 2009 | 568 |
48 | Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo | Journal of Experimental Medicine | 2000 | 560 |
49 | Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective | Nature Medicine | 2003 | 556 |
50 | Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy | Cell Death and Differentiation | 2007 | 555 |