| # | Title | Journal | Year | Citations |
|---|
| 1 | Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases | Nature Reviews Drug Discovery | 2019 | 849 |
| 2 | Transcriptional regulation of cadherins during development and carcinogenesis | International Journal of Developmental Biology | 2004 | 495 |
| 3 | Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development | Oxidative Medicine and Cellular Longevity | 2019 | 390 |
| 4 | Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes | Autophagy | 2016 | 300 |
| 5 | Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase | Nature Medicine | 2018 | 278 |
| 6 | European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) | Redox Biology | 2017 | 242 |
| 7 | Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP | Free Radical Biology and Medicine | 2015 | 196 |
| 8 | Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling | Gut | 2017 | 174 |
| 9 | NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology | Redox Biology | 2017 | 161 |
| 10 | Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A | Autophagy | 2018 | 134 |
| 11 | Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 128 |
| 12 | Clastosome: A Subtype of Nuclear Body Enriched in 19S and 20S Proteasomes, Ubiquitin, and Protein Substrates of Proteasome | Molecular Biology of the Cell | 2002 | 121 |
| 13 | Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications | Antioxidants and Redox Signaling | 2015 | 120 |
| 14 | Exosome-mimetic nanoplatforms for targeted cancer drug delivery | Journal of Nanobiotechnology | 2019 | 117 |
| 15 | Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis | Brain | 2014 | 112 |
| 16 | The PTEN/NRF2 Axis Promotes Human Carcinogenesis | Antioxidants and Redox Signaling | 2014 | 104 |
| 17 | The Transcription Factor Encyclopedia | Genome Biology | 2012 | 103 |
| 18 | Exosome secretion by eosinophils: A possible role in asthma pathogenesis | Journal of Allergy and Clinical Immunology | 2015 | 99 |
| 19 | Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease | Antioxidants and Redox Signaling | 2011 | 93 |
| 20 | Neuroprotective effect of melatonin against ischemia is partially mediated by alpha‐7 nicotinic receptor modulation and HO‐1 overexpression | Journal of Pineal Research | 2014 | 93 |
| 21 | Effects of Nrf2 Deficiency on Bone Microarchitecture in an Experimental Model of Osteoporosis | Oxidative Medicine and Cellular Longevity | 2014 | 83 |
| 22 | The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation | Aging Cell | 2019 | 80 |
| 23 | Effect of 25-OH-vitamin D on fracture healing in elderly rats | Journal of Orthopaedic Research | 1998 | 67 |
| 24 | Exosomes from eosinophils autoregulate and promote eosinophil functions | Journal of Leukocyte Biology | 2017 | 58 |
| 25 | A current perspective on cancer immune therapy: step‐by‐step approach to constructing the magic bullet | Clinical and Translational Medicine | 2017 | 58 |
| 26 | Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases | Frontiers in Pharmacology | 2020 | 55 |
| 27 | Regulation of CDC6, Geminin, and CDT1 in Human Cells that Undergo Polyploidization | Molecular Biology of the Cell | 2002 | 51 |
| 28 | WNT-3A Regulates an Axin1/NRF2 Complex That Regulates Antioxidant Metabolism in Hepatocytes | Antioxidants and Redox Signaling | 2015 | 50 |
| 29 | Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage | Trends in Endocrinology and Metabolism | 2019 | 50 |
| 30 | Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice | Gastroenterology | 2019 | 50 |
| 31 | The Role of Free Radicals in Autophagy Regulation: Implications for Ageing | Oxidative Medicine and Cellular Longevity | 2018 | 49 |
| 32 | Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery | European Journal of Obstetrics, Gynecology and Reproductive Biology | 2000 | 41 |
| 33 | VHL promotes immune response against renal cell carcinoma via NF-κB–dependent regulation of VCAM-1 | Journal of Cell Biology | 2017 | 39 |
| 34 | Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells | World Journal of Stem Cells | 2020 | 39 |
| 35 | Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases | Annual Review of Pharmacology and Toxicology | 2022 | 33 |
| 36 | Estimating the predictability of cancer evolution | Bioinformatics | 2019 | 28 |
| 37 | Every which way? On predicting tumor evolution using cancer progression models | PLoS Computational Biology | 2019 | 27 |
| 38 | Microgravity effects on the oogenesis and development of embryos of Drosophila melanogaster laid in the Spaceshuttle during the Biorack experiment (ESA) | International Journal of Developmental Biology | 1989 | 27 |
| 39 | Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis | Journal of Neurochemistry | 2009 | 25 |
| 40 | Changes in the Kinase Activity of the Insulin Receptor Account for an Increased Insulin Sensitivity of Mammary Gland in Late Pregnancy1 | Endocrinology | 1998 | 22 |
| 41 | Expression of the Murine Pomt1 Gene in Both the Developing Brain and Adult Muscle Tissues and Its Relationship with Clinical Aspects of Walker-Warburg Syndrome | American Journal of Pathology | 2007 | 22 |
| 42 | Intracellular redox equilibrium is essential for the constitutive expression of AP-1 dependent genes in resting cells: Studies on TGF-β1 regulation | International Journal of Biochemistry and Cell Biology | 2012 | 22 |
| 43 | Cancer progression models and fitness landscapes: a many-to-many relationship | Bioinformatics | 2018 | 22 |
| 44 | Low dihydropyridine receptor density in vasa deferentia of castrated rats | British Journal of Pharmacology | 1992 | 21 |
| 45 | Involvement of Both Phosphatidylinositol 3-Kinase and p44/p42 Mitogen-Activated Protein Kinase Pathways in the Short-Term Regulation of Pyruvate Kinase L by Insulin* | Endocrinology | 2001 | 20 |
| 46 | Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization | Arteriosclerosis, Thrombosis, and Vascular Biology | 2019 | 20 |
| 47 | Global epistasis on fitness landscapes | Philosophical Transactions of the Royal Society B: Biological Sciences | 2023 | 20 |
| 48 | Genome wide association study identifies a novel putative mammographic density locus at 1q12‐q21 | International Journal of Cancer | 2015 | 18 |
| 49 | OncoSimulR: genetic simulation with arbitrary epistasis and mutator genes in asexual populations | Bioinformatics | 2017 | 18 |
| 50 | The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance | Free Radical Biology and Medicine | 2022 | 13 |
