| # | Title | Journal | Year | Citations |
|---|
| 1 | Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer | Nature Genetics | 2005 | 1,710 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Effectiveness of acute geriatric units on functional decline, living at home, and case fatality among older patients admitted to hospital for acute medical disorders: meta-analysis | BMJ: British Medical Journal | 2009 | 302 |
| 4 | Association between health information, use of protective devices and occurrence of acute health problems in the Prestige oil spill clean-up in Asturias and Cantabria (Spain): a cross-sectional study | BMC Public Health | 2006 | 284 |
| 5 | Gender differences in the utilization of health-care services among the older adult population of Spain | BMC Public Health | 2006 | 279 |
| 6 | Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase | Nature Medicine | 2018 | 278 |
| 7 | Health-Related Quality of Life as a Predictor of Hospital Readmission and Death Among Patients With Heart Failure | Archives of Internal Medicine | 2005 | 251 |
| 8 | Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides | Journal of the American Society of Nephrology: JASN | 2015 | 205 |
| 9 | Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients | Biochemical and Biophysical Research Communications | 2003 | 193 |
| 10 | Cognitive-Emotional Hyperarousal as a Premorbid Characteristic of Individuals Vulnerable to Insomnia | Psychosomatic Medicine | 2010 | 193 |
| 11 | Colocalization of cholinesterases with ? amyloid protein in aged and Alzheimer's brains | Acta Neuropathologica | 1993 | 168 |
| 12 | Social network and health-related quality of life in older adults: A population-based study in Spain | Quality of Life Research | 2005 | 168 |
| 13 | The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 via Nuclear Factor Erythroid-2-Related Factor 2 | Antioxidants and Redox Signaling | 2013 | 162 |
| 14 | Mapping 123 million neonatal, infant and child deaths between 2000 and 2017 | Nature | 2019 | 161 |
| 15 | Selected eating behaviours and excess body weight: a systematic review | Obesity Reviews | 2012 | 158 |
| 16 | Immunophenotypic Characterization and Quantification of the Epithelial Inflammatory Infiltrate in Eosinophilic Esophagitis Through Stereology | American Journal of Surgical Pathology | 2007 | 154 |
| 17 | Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome | Cell | 2021 | 151 |
| 18 | Assessment of an after-school physical activity program to prevent obesity among 9- to 10-year-old children: a cluster randomized trial | International Journal of Obesity | 2008 | 145 |
| 19 | Social Network as a Predictor of Hospital Readmission and Mortality Among Older Patients With Heart Failure | Journal of Cardiac Failure | 2006 | 142 |
| 20 | Insomnia and sleep quality among primary care physicians with low and high burnout levels | Journal of Psychosomatic Research | 2008 | 137 |
| 21 | Mortality from diseases other than cancer following low doses of ionizing radiation: results from the 15-Country Study of nuclear industry workers | International Journal of Epidemiology | 2007 | 135 |
| 22 | Sleep duration, general and abdominal obesity, and weight change among the older adult population of Spain | American Journal of Clinical Nutrition | 2008 | 135 |
| 23 | The Spanish version of the Insomnia Severity Index: A confirmatory factor analysis | Sleep Medicine | 2012 | 134 |
| 24 | Nitric oxide mediates tumor necrosis factor-α cytotoxicity in endothelial cells | Biochemical and Biophysical Research Communications | 1992 | 133 |
| 25 | Usual sleep duration and cognitive function in older adults in Spain | Journal of Sleep Research | 2009 | 130 |
| 26 | A simple estimate of mortality attributable to excess weight in the European Union | European Journal of Clinical Nutrition | 2003 | 128 |
| 27 | Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 128 |
| 28 | Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension | Antioxidants and Redox Signaling | 2013 | 127 |
| 29 | Exosome-mimetic nanoplatforms for targeted cancer drug delivery | Journal of Nanobiotechnology | 2019 | 117 |
| 30 | Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2008 | 116 |
| 31 | Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2 | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2014 | 116 |
| 32 | NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage | Proceedings of the National Academy of Sciences of the United States of America | 2017 | 112 |
| 33 | Electrophysiological evidence for the existence of a posterior cortical–prefrontal–basal forebrain circuitry in modulating sensory responses in visual and somatosensory rat cortical areas | Neuroscience | 2003 | 108 |
| 34 | Brain Repair and Neuroprotection by Serum Insulin-Like Growth Factor I | Molecular Neurobiology | 2003 | 106 |
| 35 | Waist Circumference as a Predictor of Disability among Older Adults | Obesity | 2007 | 103 |
| 36 | The Transcription Factor Encyclopedia | Genome Biology | 2012 | 103 |
| 37 | A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality | Antimicrobial Agents and Chemotherapy | 2020 | 102 |
| 38 | Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases | Cardiovascular Diabetology | 2019 | 101 |
| 39 | Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice | Nature Communications | 2021 | 101 |
| 40 | Testicular Microlithiasis in 2 Children with Bilateral Cryptorchidism | Journal of Urology | 1979 | 100 |
| 41 | Prevalence of white-coat and masked hypertension in national and international registries | Hypertension Research | 2015 | 100 |
| 42 | Brain Glutamine Synthesis Requires Neuronal-Born Aspartate as Amino Donor for Glial Glutamate Formation | Journal of Cerebral Blood Flow and Metabolism | 2011 | 98 |
| 43 | Adhesion dynamics at a glance | Journal of Cell Science | 2011 | 95 |
| 44 | An update review of intradialytic hypotension: concept, risk factors, clinical implications and management | CKJ: Clinical Kidney Journal | 2020 | 89 |
| 45 | Local NADPH—Diaphorase Neurons Innervate Pial Arteries and Lie Close or Project to Intracerebral Blood Vessels: A Possible Role for Nitric Oxide in the Regulation of Cerebral Blood Flow | Journal of Cerebral Blood Flow and Metabolism | 1993 | 88 |
| 46 | Eating behaviours and obesity in the adult population of Spain | British Journal of Nutrition | 2008 | 81 |
| 47 | A quantitative morphological study of human Leydig cells from birth to adulthood | Cell and Tissue Research | 1986 | 80 |
| 48 | Nitric Oxide Mediates the Neurogenic Vasodilation of Bovine Cerebral Arteries | Journal of Cerebral Blood Flow and Metabolism | 1991 | 80 |
| 49 | DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications? | Frontiers in Pharmacology | 2020 | 80 |
| 50 | Air pollution and kidney disease: review of current evidence | CKJ: Clinical Kidney Journal | 2019 | 78 |
