| # | Title | Journal | Year | Citations |
|---|
| 1 | Robust enumeration of cell subsets from tissue expression profiles | Nature Methods | 2015 | 8,460 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Determining cell type abundance and expression from bulk tissues with digital cytometry | Nature Biotechnology | 2019 | 2,396 |
| 4 | Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours | Nature | 1996 | 2,223 |
| 5 | A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage | Current Biology | 2000 | 1,867 |
| 6 | An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage | Nature Medicine | 2014 | 1,771 |
| 7 | Nasopharyngeal carcinoma | Lancet, The | 2019 | 1,667 |
| 8 | Pre-metastatic niches: organ-specific homes for metastases | Nature Reviews Cancer | 2017 | 1,272 |
| 9 | The complexity of p53 modulation: emerging patterns from divergent signals | Genes and Development | 1998 | 1,154 |
| 10 | The unique physiology of solid tumors: opportunities (and problems) for cancer therapy | Cancer Research | 1998 | 1,141 |
| 11 | Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin | Molecular and Cellular Biology | 2002 | 1,106 |
| 12 | Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial | Lancet, The | 2019 | 879 |
| 13 | Integrated digital error suppression for improved detection of circulating tumor DNA | Nature Biotechnology | 2016 | 837 |
| 14 | Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling | Cancer Discovery | 2017 | 701 |
| 15 | Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer | JAMA Oncology | 2020 | 696 |
| 16 | Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice | Journal of Clinical Investigation | 2010 | 686 |
| 17 | Factors Affecting Late Mortality From Heart Disease After Treatment of Hodgkin's Disease | JAMA - Journal of the American Medical Association | 1993 | 613 |
| 18 | Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. | Molecular and Cellular Biology | 1994 | 587 |
| 19 | Loss of PTEN facilitates HIF-1-mediated gene expression | Genes and Development | 2000 | 561 |
| 20 | FoxO3 Regulates Neural Stem Cell Homeostasis | Cell Stem Cell | 2009 | 526 |
| 21 | Apoptosis, p53, and tumor cell sensitivity to anticancer agents | Cancer Research | 1999 | 524 |
| 22 | SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation | Nature | 2012 | 503 |
| 23 | The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture | Cancer Research | 1999 | 500 |
| 24 | XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth | Cancer Research | 2004 | 496 |
| 25 | Modern Radiation Therapy for Hodgkin Lymphoma: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group (ILROG) | International Journal of Radiation Oncology Biology Physics | 2014 | 479 |
| 26 | The changing therapeutic landscape of head and neck cancer | Nature Reviews Clinical Oncology | 2019 | 454 |
| 27 | Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma | Cancer | 2015 | 447 |
| 28 | Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline | Practical Radiation Oncology | 2018 | 431 |
| 29 | Penalized weighted least-squares approach to sinogram noise reduction and image reconstruction for low-dose X-ray computed tomography | IEEE Transactions on Medical Imaging | 2006 | 425 |
| 30 | Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer | International Journal of Radiation Oncology Biology Physics | 2004 | 420 |
| 31 | Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13 | Developmental Cell | 2002 | 419 |
| 32 | Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line | Cell Death and Differentiation | 2002 | 410 |
| 33 | Segmentation of organs‐at‐risks in head and neck CT images using convolutional neural networks | Medical Physics | 2017 | 398 |
| 34 | Integrating genomic features for non-invasive early lung cancer detection | Nature | 2020 | 379 |
| 35 | Frequency-dependent FDTD methods using Z transforms | IEEE Transactions on Antennas and Propagation | 1992 | 375 |
| 36 | Asymptomatic cardiac disease following mediastinal irradiation | Journal of the American College of Cardiology | 2003 | 349 |
| 37 | MiR-210 – micromanager of the hypoxia pathway | Trends in Molecular Medicine | 2010 | 343 |
| 38 | Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging | Journal of the American Chemical Society | 2014 | 338 |
| 39 | The ever-expanding role of HIF in tumour and stromal biology | Nature Cell Biology | 2016 | 337 |
| 40 | Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects | Nature Genetics | 2008 | 334 |
| 41 | SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours | British Journal of Cancer | 1993 | 333 |
| 42 | Utilization of special education services and educational attainment among long-term survivors of childhood cancer | Cancer | 2003 | 327 |
| 43 | Hypoxia, inflammation, and the tumor microenvironment in metastatic disease | Cancer and Metastasis Reviews | 2010 | 321 |
| 44 | Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1α Enhances Hypoxic Gene Expression and Tumor Growth | Molecular and Cellular Biology | 2010 | 312 |
| 45 | Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer | International Journal of Radiation Oncology Biology Physics | 2005 | 308 |
| 46 | Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group | International Journal of Radiation Oncology Biology Physics | 2015 | 303 |
| 47 | Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro | Molecular and Cellular Biology | 2007 | 295 |
| 48 | Tracking moving organs in real time | Seminars in Radiation Oncology | 2004 | 294 |
| 49 | Cells at Intermediate Oxygen Levels Can Be More Important Than the "Hypoxic Fraction" in Determining Tumor Response to Fractionated Radiotherapy | Radiation Research | 1997 | 288 |
| 50 | Hypoxia Links ATR and p53 through Replication Arrest | Molecular and Cellular Biology | 2002 | 283 |
