| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia | Blood | 2016 | 7,429 |
| 2 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | The prognostic landscape of genes and infiltrating immune cells across human cancers | Nature Medicine | 2015 | 2,505 |
| 5 | A clonogenic common myeloid progenitor that gives rise to all myeloid lineages | Nature | 2000 | 2,194 |
| 6 | Rejuvenation of aged progenitor cells by exposure to a young systemic environment | Nature | 2005 | 1,926 |
| 7 | Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow | Cell | 1997 | 1,912 |
| 8 | Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis | Cell | 2015 | 1,791 |
| 9 | Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells | Nature | 2003 | 1,768 |
| 10 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy | Cell | 1995 | 1,638 |
| 11 | Stem Cells | Cell | 2000 | 1,623 |
| 12 | Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Cell | 2015 | 1,485 |
| 13 | The development of allergic inflammation | Nature | 2008 | 1,475 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 15 | Architecture of the human regulatory network derived from ENCODE data | Nature | 2012 | 1,384 |
| 16 | α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1 | Cell | 1993 | 1,378 |
| 17 | Evolutionary and Biomedical Insights from the Rhesus Macaque Genome | Science | 2007 | 1,283 |
| 18 | Gene expression profiling identifies clinically relevant subtypes of prostate cancer | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,175 |
| 19 | Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors | Science | 1989 | 1,101 |
| 20 | The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype | Immunity | 1994 | 976 |
| 21 | Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus | Nature | 2013 | 961 |
| 22 | α4 integrins mediate lymphocyte attachment and rolling under physiologic flow | Cell | 1995 | 959 |
| 23 | Identification of a putative regulator of early T cell activation genes | Science | 1988 | 922 |
| 24 | Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia | New England Journal of Medicine | 2004 | 915 |
| 25 | Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma | Cell | 2010 | 894 |
| 26 | Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias | Cell | 1992 | 890 |
| 27 | Multiplexed ion beam imaging of human breast tumors | Nature Medicine | 2014 | 881 |
| 28 | Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease | New England Journal of Medicine | 1989 | 875 |
| 29 | Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils | Nature Immunology | 2011 | 859 |
| 30 | B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies | Nature Medicine | 2011 | 858 |
| 31 | Langerhans cells renew in the skin throughout life under steady-state conditions | Nature Immunology | 2002 | 857 |
| 32 | Integrated digital error suppression for improved detection of circulating tumor DNA | Nature Biotechnology | 2016 | 837 |
| 33 | ELAM-1 is an adhesion molecule for skin-homing T cells | Nature | 1991 | 836 |
| 34 | The aging of hematopoietic stem cells | Nature Medicine | 1996 | 790 |
| 35 | The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells | Nature | 1999 | 787 |
| 36 | Natural History and Treated Course of Usual and Desquamative Interstitial Pneumonia | New England Journal of Medicine | 1978 | 755 |
| 37 | Pathologic Features of Prognostic Significance in Adrenocortical Carcinoma | American Journal of Surgical Pathology | 1989 | 738 |
| 38 | Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 730 |
| 39 | A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging | Cell | 2018 | 729 |
| 40 | Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity | Nature Medicine | 2002 | 728 |
| 41 | pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane | Cell | 1987 | 721 |
| 42 | A tissue-specific endothelial cell molecule involved in lymphocyte homing | Nature | 1988 | 709 |
| 43 | Systemic Immunity Is Required for Effective Cancer Immunotherapy | Cell | 2017 | 708 |
| 44 | Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma | Cell Reports | 2017 | 701 |
| 45 | Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling | Cancer Discovery | 2017 | 701 |
| 46 | Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein | Nature | 1986 | 697 |
| 47 | Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus | Cell | 1988 | 695 |
| 48 | Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features | Nature Communications | 2016 | 694 |
| 49 | The winnowing: establishing the squid–vibrio symbiosis | Nature Reviews Microbiology | 2004 | 689 |
| 50 | The Biology of Hematopoietic Stem Cells | Annual Review of Cell and Developmental Biology | 1995 | 687 |
