| # | Title | Journal | Year | Citations |
|---|
| 1 | Robust enumeration of cell subsets from tissue expression profiles | Nature Methods | 2015 | 8,460 |
| 2 | The 2016 revision of the World Health Organization classification of lymphoid neoplasms | Blood | 2016 | 5,965 |
| 3 | The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008 | Journal of Clinical Epidemiology | 2010 | 3,521 |
| 4 | The prognostic landscape of genes and infiltrating immune cells across human cancers | Nature Medicine | 2015 | 2,505 |
| 5 | Determining cell type abundance and expression from bulk tissues with digital cytometry | Nature Biotechnology | 2019 | 2,396 |
| 6 | Chronic inflammation in the etiology of disease across the life span | Nature Medicine | 2019 | 2,195 |
| 7 | The development of androgen-independent prostate cancer | Nature Reviews Cancer | 2001 | 2,057 |
| 8 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 9 | Profiling Tumor Infiltrating Immune Cells with CIBERSORT | Methods in Molecular Biology | 2018 | 1,936 |
| 10 | An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage | Nature Medicine | 2014 | 1,771 |
| 11 | Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2014 | 1,711 |
| 12 | Rheumatoid Arthritis | New England Journal of Medicine | 1990 | 1,608 |
| 13 | IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma | Blood | 1997 | 1,555 |
| 14 | Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray | Science | 1999 | 1,434 |
| 15 | Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,373 |
| 16 | Development and evaluation of a scale to measure perceived self-efficacy in people with arthritis | Arthritis and Rheumatism | 1989 | 1,367 |
| 17 | Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues | Nature Nanotechnology | 2016 | 1,223 |
| 18 | Identification of the Uncultured Bacillus of Whipple’s Disease | New England Journal of Medicine | 1992 | 1,196 |
| 19 | Increasing value and reducing waste in research design, conduct, and analysis | Lancet, The | 2014 | 1,186 |
| 20 | Executive Summary: Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2014 | 1,156 |
| 21 | Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes | Cell | 2012 | 1,134 |
| 22 | The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method | BMC Medical Research Methodology | 2014 | 1,095 |
| 23 | Financial crisis, austerity, and health in Europe | Lancet, The | 2013 | 1,077 |
| 24 | High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA | Molecular Genetics and Genomics | 1979 | 1,050 |
| 25 | Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA | Nucleic Acids Research | 1984 | 968 |
| 26 | SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin | Nature | 2008 | 945 |
| 27 | Insulin-Dependent Diabetes Mellitus | Cell | 1996 | 929 |
| 28 | Polyarginine enters cells more efficiently than other polycationic homopolymers | Chemical Biology and Drug Design | 2000 | 918 |
| 29 | B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies | Nature Medicine | 2011 | 858 |
| 30 | Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry | Annals of Oncology | 2019 | 842 |
| 31 | Integrated digital error suppression for improved detection of circulating tumor DNA | Nature Biotechnology | 2016 | 837 |
| 32 | Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates | Clinical Microbiology Reviews | 1996 | 799 |
| 33 | MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer | Nature | 2004 | 796 |
| 34 | The biological and clinical significance of emerging SARS-CoV-2 variants | Nature Reviews Genetics | 2021 | 778 |
| 35 | Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists | PLoS Medicine | 2018 | 773 |
| 36 | Right Heart Adaptation to Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2013 | 770 |
| 37 | Role of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition | Annual Review of Medicine | 1993 | 766 |
| 38 | Evidence suggesting that health education for self-management in patients with chronic arthritis has sustained health benefits while reducing health care costs | Arthritis and Rheumatism | 1993 | 757 |
| 39 | Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 743 |
| 40 | Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report | Diabetes Care | 2019 | 734 |
| 41 | Human immunodeficiency virus reverse transcriptase and protease sequence database | Nucleic Acids Research | 2003 | 730 |
| 42 | Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice | Nature | 1995 | 713 |
| 43 | CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells | Nature | 2016 | 709 |
| 44 | Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling | Cancer Discovery | 2017 | 701 |
| 45 | Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer | JAMA Oncology | 2020 | 696 |
| 46 | Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB–IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial | Lancet, The | 2021 | 689 |
| 47 | Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed | Molecular and Cellular Biology | 1983 | 674 |
| 48 | Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia | Nature Medicine | 2000 | 651 |
| 49 | American Gastroenterological Association Institute Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation During Immunosuppressive Drug Therapy | Gastroenterology | 2015 | 634 |
| 50 | Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial | Lancet Respiratory Medicine,the | 2015 | 614 |
