| # | Title | Journal | Year | Citations |
|---|
| 1 | A behavioral assessment of Ts65Dn mice: a putative Down syndrome model | Neuroscience Letters | 1995 | 233 |
| 2 | Melatonin-estrogen interactions in breast cancer | Journal of Pineal Research | 2005 | 204 |
| 3 | A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity | Nature Neuroscience | 2004 | 196 |
| 4 | Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells | Cancer Research | 1998 | 185 |
| 5 | Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain | European Journal of Neuroscience | 2003 | 184 |
| 6 | Melatonin increases p53 and p21WAFl expression in MCF-7 human breast cancer cells in vitro | Life Sciences | 1999 | 165 |
| 7 | Cellular Senescence in Neurodegenerative Diseases | Frontiers in Cellular Neuroscience | 2020 | 164 |
| 8 | Estrogen-signaling pathway: A link between breast cancer and melatonin oncostatic actions | Cancer Detection and Prevention | 2006 | 152 |
| 9 | Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities | Neural Plasticity | 2012 | 151 |
| 10 | Melatonin and Mammary Pathological Growth | Frontiers in Neuroendocrinology | 2000 | 150 |
| 11 | Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome | Neuroscience Letters | 1998 | 149 |
| 12 | Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome | Neuroscience Letters | 1998 | 137 |
| 13 | Reducing GABAAα5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome | Journal of Neuroscience | 2013 | 137 |
| 14 | Melatonin and mammary cancer: a short review. | Endocrine-Related Cancer | 2003 | 128 |
| 15 | Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome | Neuroscience Letters | 2008 | 125 |
| 16 | Differential Distribution of [ 3 H]Sumatriptan Binding Sites (5-HT 1B , 5-HT 1D and 5-HT 1F Receptors) in Human Brain: Focus on Brainstem and Spinal Cord | Neuropharmacology | 1997 | 124 |
| 17 | Strategies for producing faster acting antidepressants | Drug Discovery Today | 2005 | 122 |
| 18 | Selective Increase of α2A‐Adrenoceptor Agonist Binding Sites in Brains of Depressed Suicide Victims | Journal of Neurochemistry | 1998 | 118 |
| 19 | Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice | Brain Research | 2000 | 115 |
| 20 | The Koolen-de Vries syndrome: a phenotypic comparison of patients with a 17q21.31 microdeletion versus a KANSL1 sequence variant | European Journal of Human Genetics | 2016 | 108 |
| 21 | Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT1A receptors in rat brain | Neuropharmacology | 2003 | 102 |
| 22 | Melatonin modulates aromatase activity in MCF-7 human breast cancer cells | Journal of Pineal Research | 2005 | 99 |
| 23 | Autoradiographic distribution of M1, M2, M3, and M4 muscarinic receptor subtypes in Alzheimer's disease | Synapse | 1997 | 98 |
| 24 | Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome | Brain Research | 1997 | 97 |
| 25 | Does melatonin induce apoptosis in MCF-7 human breast cancer cells in vitro? | Journal of Pineal Research | 2002 | 96 |
| 26 | Autoradiographic distribution of 5-HT7 receptors in the human brain using [3 H]mesulergine: comparison to other mammalian species | British Journal of Pharmacology | 2004 | 96 |
| 27 | Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells | Journal of Pineal Research | 2013 | 94 |
| 28 | Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity | International Journal of Cancer | 2006 | 89 |
| 29 | Melatonin inhibits both ERα activation and breast cancer cell proliferation induced by a metalloestrogen, cadmium | Journal of Pineal Research | 2006 | 88 |
| 30 | Memantine Normalizes Several Phenotypic Features in the Ts65Dn Mouse Model of Down Syndrome | Journal of Alzheimer's Disease | 2010 | 85 |
| 31 | Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome | PLoS ONE | 2014 | 81 |
| 32 | Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells | British Journal of Cancer | 2009 | 79 |
| 33 | Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome | Behavioural Brain Research | 2005 | 75 |
| 34 | Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin | Life Sciences | 1996 | 73 |
| 35 | Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain | European Journal of Pharmacology | 2002 | 73 |
| 36 | CB1 knockout mice display impaired functionality of 5‐HT1A and 5‐HT2A/C receptors | Journal of Neurochemistry | 2007 | 73 |
| 37 | Melatonin inhibits dna synthesis in mcf-7 human breast cancer cells in vitro | Life Sciences | 1996 | 72 |
| 38 | Melatonin as a Selective Estrogen Enzyme Modulator | Current Cancer Drug Targets | 2008 | 72 |
| 39 | Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes | Neurobiology of Disease | 2017 | 72 |
| 40 | β-blocker Binding to Human 5-HT1A Receptors in vivo and in vitro Implications for Antidepressant Therapy | Neuropsychopharmacology | 2000 | 70 |
| 41 | Melatonin, experimental basis for a possible application in breast cancer prevention and treatment | Histology and Histopathology | 2000 | 70 |
| 42 | Role of melatonin in the epigenetic regulation of breast cancer | Breast Cancer Research and Treatment | 2009 | 68 |
| 43 | Clinical Uses of Melatonin in Pediatrics | International Journal of Pediatrics (United Kingdom) | 2011 | 67 |
| 44 | Antiangiogenic effects of melatonin in endothelial cell cultures | Microvascular Research | 2013 | 65 |
| 45 | Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization | Neuroscience | 1996 | 64 |
| 46 | [3H]Sumatriptan binding sites in human brain: regional-dependent labelling of 5-HT1D and 5-HT1F receptors | European Journal of Pharmacology | 1996 | 64 |
| 47 | Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers | International Journal of Endocrinology | 2018 | 64 |
| 48 | Murine models for Down syndrome | Physiology and Behavior | 2001 | 62 |
| 49 | Melatonin down-regulates hTERT expression induced by either natural estrogens (17β-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells | Cancer Letters | 2008 | 62 |
| 50 | Long-Term Fluoxetine Treatment Modulates Cannabinoid Type 1 Receptor-Mediated Inhibition of Adenylyl Cyclase in the Rat Prefrontal Cortex through 5-Hydroxytryptamine1AReceptor-Dependent Mechanisms | Molecular Pharmacology | 2010 | 62 |
