| # | Title | Journal | Year | Citations |
|---|
| 1 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,634 |
| 2 | SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology | Nature Reviews Endocrinology | 2017 | 696 |
| 3 | Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data | Lancet Diabetes and Endocrinology,the | 2015 | 604 |
| 4 | PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project | Journal of Thoracic Oncology | 2018 | 589 |
| 5 | Somatic RHOA mutation in angioimmunoblastic T cell lymphoma | Nature Genetics | 2014 | 542 |
| 6 | Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria | Surgery Today | 2016 | 541 |
| 7 | Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers | Nature | 2016 | 536 |
| 8 | T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow | Journal of Experimental Medicine | 2014 | 462 |
| 9 | Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks | Nature Genetics | 2018 | 426 |
| 10 | Continuous support for women during childbirth | The Cochrane Library | 2017 | 396 |
| 11 | Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain | Nature Medicine | 2012 | 375 |
| 12 | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics | Nature Communications | 2017 | 373 |
| 13 | Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes | Nature Medicine | 2020 | 372 |
| 14 | Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment | Nature Reviews Neurology | 2019 | 364 |
| 15 | Dynamics of clonal evolution in myelodysplastic syndromes | Nature Genetics | 2017 | 348 |
| 16 | Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke | JAMA - Journal of the American Medical Association | 2021 | 348 |
| 17 | Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms | Nature Genetics | 2013 | 334 |
| 18 | Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome | Journal of the American College of Cardiology | 2015 | 315 |
| 19 | Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition | Journal of Obstetrics and Gynaecology Research | 2014 | 307 |
| 20 | Abnormal asymmetries in subcortical brain volume in schizophrenia | Molecular Psychiatry | 2016 | 300 |
| 21 | ctDNA guiding adjuvant immunotherapy in urothelial carcinoma | Nature | 2021 | 293 |
| 22 | SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism | Cell Metabolism | 2017 | 263 |
| 23 | Molecular International Prognostic Scoring System for Myelodysplastic Syndromes | Cell Metabolism | 2022 | 259 |
| 24 | A mitochondrial superoxide theory for oxidative stress diseases and aging | Journal of Clinical Biochemistry and Nutrition | 2015 | 253 |
| 25 | Chemical Principles in Tissue Clearing and Staining Protocols for Whole-Body Cell Profiling | Annual Review of Cell and Developmental Biology | 2016 | 238 |
| 26 | Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy | Nature Genetics | 2018 | 238 |
| 27 | Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis | The Lancet Global Health | 2018 | 237 |
| 28 | Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure | Journal of the American College of Cardiology | 2017 | 235 |
| 29 | Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 232 |
| 30 | The podocyte's response to stress: the enigma of foot process effacement | American Journal of Physiology - Renal Physiology | 2013 | 231 |
| 31 | Adjuvant atezolizumab versus observation in muscle-invasive urothelial carcinoma (IMvigor010): a multicentre, open-label, randomised, phase 3 trial | Lancet Oncology, The | 2021 | 225 |
| 32 | High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry | Nature Genetics | 2016 | 219 |
| 33 | A global analysis of Y-chromosomal haplotype diversity for 23 STR loci | Forensic Science International: Genetics | 2014 | 214 |
| 34 | Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders | Annals of Neurology | 2015 | 212 |
| 35 | Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study | Modern Pathology | 2012 | 206 |
| 36 | Clinical Implications of Intrarenal Hemodynamic Evaluation by Doppler Ultrasonography in Heart Failure | JACC: Heart Failure | 2016 | 202 |
| 37 | Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration | Cell | 2020 | 185 |
| 38 | Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study | Journal of Thoracic Oncology | 2016 | 184 |
| 39 | The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis | Science Translational Medicine | 2017 | 182 |
| 40 | Comparison of treatment invasiveness between upfront debulking surgery versus interval debulking surgery following neoadjuvant chemotherapy for stage III/IV ovarian, tubal, and peritoneal cancers in a phase III randomised trial: Japan Clinical Oncology Group Study JCOG0602 | European Journal of Cancer | 2016 | 180 |
| 41 | Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease | Cell Metabolism | 2018 | 180 |
| 42 | Distribution and Prognostic Significance of Left Ventricular Global Longitudinal Strain in Asymptomatic Significant Aortic Stenosis | JACC: Cardiovascular Imaging | 2019 | 178 |
| 43 | Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study | Brain | 2020 | 173 |
| 44 | ZNF384 -related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype | Haematologica | 2017 | 172 |
| 45 | Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 171 |
| 46 | Correlation between vitiligo occurrence and clinical benefit in advanced melanoma patients treated with nivolumab: A multi‐institutional retrospective study | Journal of Dermatology | 2017 | 170 |
| 47 | White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals | Molecular Psychiatry | 2020 | 170 |
| 48 | Epidemiology of urothelial carcinoma | International Journal of Urology | 2017 | 164 |
| 49 | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology | FEBS Letters | 2018 | 164 |
| 50 | iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease | Cell Reports | 2017 | 161 |
