| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | What low back pain is and why we need to pay attention | Lancet, The | 2018 | 2,444 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | PAX3: A Molecule with Oncogenic or Tumor Suppressor Function Is Involved in Cancer | BioMed Research International | 2018 | 865 |
| 5 | Genome-wide Analyses Identify KIF5A as a Novel ALS Gene | Neuron | 2018 | 517 |
| 6 | Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis | Nature Genetics | 2016 | 494 |
| 7 | Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice | Science Translational Medicine | 2018 | 493 |
| 8 | Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: A systematic review, meta-analyses, and meta-regression | Journal of Hepatology | 2017 | 390 |
| 9 | The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review | Oxidative Medicine and Cellular Longevity | 2016 | 363 |
| 10 | Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial | Lancet, The | 2016 | 321 |
| 11 | Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases | Neuropharmacology | 2017 | 281 |
| 12 | Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma | Oncotarget | 2015 | 278 |
| 13 | Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study | Lancet HIV,the | 2018 | 273 |
| 14 | ICBT in routine care: A descriptive analysis of successful clinics in five countries | Internet Interventions | 2018 | 273 |
| 15 | Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity | Nature Communications | 2017 | 265 |
| 16 | Circulating tumour DNA predicts response to anti-PD1 antibodies in metastatic melanoma | Annals of Oncology | 2017 | 253 |
| 17 | Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1–Based Immunotherapy | Clinical Cancer Research | 2019 | 249 |
| 18 | Association Between Circulating Tumor DNA and Pseudoprogression in Patients With Metastatic Melanoma Treated With Anti–Programmed Cell Death 1 Antibodies | JAMA Oncology | 2018 | 229 |
| 19 | NEK1 variants confer susceptibility to amyotrophic lateral sclerosis | Nature Genetics | 2016 | 218 |
| 20 | Knee osteoarthritis phenotypes and their relevance for outcomes: a systematic review | Osteoarthritis and Cartilage | 2017 | 207 |
| 21 | Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA | ACS Chemical Neuroscience | 2015 | 202 |
| 22 | Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression | Nature Genetics | 2020 | 192 |
| 23 | Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression | Scientific Reports | 2017 | 183 |
| 24 | Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB | PLoS ONE | 2015 | 181 |
| 25 | Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization | European Heart Journal | 2017 | 175 |
| 26 | CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia | Nature Communications | 2016 | 174 |
| 27 | Task errors by emergency physicians are associated with interruptions, multitasking, fatigue and working memory capacity: a prospective, direct observation study | BMJ Quality and Safety | 2018 | 173 |
| 28 | Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders | International Journal of Molecular Sciences | 2019 | 173 |
| 29 | Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 | ACS Chemical Neuroscience | 2015 | 167 |
| 30 | Where the rubber meets the road: using FRAM to align work-as-imagined with work-as-done when implementing clinical guidelines | Implementation Science | 2015 | 166 |
| 31 | The State of Lung Cancer Research: A Global Analysis | Journal of Thoracic Oncology | 2016 | 166 |
| 32 | The Personalization of Conversational Agents in Health Care: Systematic Review | Journal of Medical Internet Research | 2019 | 166 |
| 33 | Dendritic spines: Revisiting the physiological role | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2019 | 165 |
| 34 | Neuroinflammation in frontotemporal dementia | Nature Reviews Neurology | 2019 | 159 |
| 35 | Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation | Nature Communications | 2018 | 158 |
| 36 | Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia | Molecular Psychiatry | 2020 | 155 |
| 37 | Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma | Nature Genetics | 2018 | 152 |
| 38 | Risk factors for low back pain and sciatica: an umbrella review | Spine Journal | 2018 | 150 |
| 39 | Effective and Targeted Human Orthotopic Glioblastoma Xenograft Therapy via a Multifunctional Biomimetic Nanomedicine | Advanced Materials | 2018 | 148 |
| 40 | Intensive care unit environmental surfaces are contaminated by multidrug-resistant bacteria in biofilms: combined results of conventional culture, pyrosequencing, scanning electron microscopy, and confocal laser microscopy | Journal of Hospital Infection | 2015 | 143 |
| 41 | The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer | Archives of Pathology and Laboratory Medicine | 2021 | 143 |
| 42 | An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation | Translational Psychiatry | 2016 | 141 |
| 43 | Is Motorized Treadmill Running Biomechanically Comparable to Overground Running? A Systematic Review and Meta-Analysis of Cross-Over Studies | Sports Medicine | 2020 | 141 |
| 44 | Motor Neuron Susceptibility in ALS/FTD | Frontiers in Neuroscience | 2019 | 140 |
| 45 | The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD | Frontiers in Neuroscience | 2019 | 135 |
| 46 | The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal | International Journal of Tryptophan Research | 2019 | 134 |
| 47 | The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins | Glia | 2020 | 133 |
| 48 | DEXAMETHASONE IMPLANT FOR DIABETIC MACULAR EDEMA IN NAIVE COMPARED WITH REFRACTORY EYES | Retina | 2019 | 130 |
| 49 | Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status | International Journal of Tryptophan Research | 2019 | 129 |
| 50 | Risk Factors for Falls in Community Stroke Survivors: A Systematic Review and Meta-Analysis | Archives of Physical Medicine and Rehabilitation | 2018 | 126 |
