| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice | Journal of Experimental Medicine | 2000 | 1,458 |
| 3 | Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use | Nature Genetics | 2019 | 1,307 |
| 4 | Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives | Biophysical Journal | 1999 | 1,068 |
| 5 | Polycystic ovary syndrome | Nature Reviews Disease Primers | 2016 | 1,004 |
| 6 | KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene | Journal of the National Cancer Institute | 1996 | 867 |
| 7 | Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters | Journal of Cerebral Blood Flow and Metabolism | 2007 | 678 |
| 8 | Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome | Endocrine Reviews | 2015 | 649 |
| 9 | Insomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension | Sleep | 2009 | 629 |
| 10 | Effects of surface wettability and contact time on protein adhesion to biomaterial surfaces | Biomaterials | 2007 | 586 |
| 11 | Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder | Sleep Medicine Reviews | 2013 | 572 |
| 12 | Assessment and Management of Foot Disease in Patients with Diabetes | New England Journal of Medicine | 1994 | 543 |
| 13 | Expanded 2-Year Follow-up of Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema | Ophthalmology | 2011 | 525 |
| 14 | Cell Sensing and Response to Micro- and Nanostructured Surfaces Produced by Chemical and Topographic Patterning | Tissue Engineering | 2007 | 495 |
| 15 | Polyamine metabolism and cancer: treatments, challenges and opportunities | Nature Reviews Cancer | 2018 | 468 |
| 16 | Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease | Science | 2016 | 438 |
| 17 | Preassociation of Calmodulin with Voltage-Gated Ca2+ Channels Revealed by FRET in Single Living Cells | Neuron | 2001 | 430 |
| 18 | Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction | Nature Communications | 2015 | 413 |
| 19 | Near-Infrared Emitting Fluorophore-Doped Calcium Phosphate Nanoparticles for In Vivo Imaging of Human Breast Cancer | ACS Nano | 2008 | 405 |
| 20 | The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice | Molecular and Cellular Biology | 2002 | 395 |
| 21 | The astacin family of metalloendopeptidases | Protein Science | 1995 | 391 |
| 22 | Orally Administered Leucine Stimulates Protein Synthesis in Skeletal Muscle of Postabsorptive Rats in Association with Increased eIF4F Formation | Journal of Nutrition | 2000 | 390 |
| 23 | Adolescent Girls with Polycystic Ovary Syndrome Have an Increased Risk of the Metabolic Syndrome Associated with Increasing Androgen Levels Independent of Obesity and Insulin Resistance | Journal of Clinical Endocrinology and Metabolism | 2006 | 383 |
| 24 | The facilitative glucose transporter GLUT3: 20 years of distinction | American Journal of Physiology - Endocrinology and Metabolism | 2008 | 367 |
| 25 | Neurological and Neuropsychological Bases of Empathy | European Neurology | 1998 | 358 |
| 26 | Alterations in vasomotor tone in congestive heart failure | Progress in Cardiovascular Diseases | 1982 | 350 |
| 27 | Sleep Apnea and Sleep Disruption in Obese Patients | Archives of Internal Medicine | 1994 | 344 |
| 28 | North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens | Journal of the American Academy of Dermatology | 1998 | 339 |
| 29 | Estimating the Harms of Nicotine-Containing Products Using the MCDA Approach | European Addiction Research | 2014 | 337 |
| 30 | Weight-related attitudes and behaviors of black women | Journal of the American Dietetic Association | 1993 | 327 |
| 31 | Properties of Hamster Embryo Fibroblasts Transformed In Vitro After Exposure to Ultraviolet-Irradiated Herpes Simplex Virus Type 2 | Journal of Virology | 1971 | 320 |
| 32 | Development of a Questionnaire for Assessing Dependence on Electronic Cigarettes Among a Large Sample of Ex-Smoking E-cigarette Users | Nicotine and Tobacco Research | 2015 | 319 |
| 33 | Induction of autophagy by amino-acid deprivation in perfused rat liver | Nature | 1977 | 317 |
| 34 | Regulation of Protein Synthesis in Heart Muscle | Journal of Biological Chemistry | 1971 | 314 |
| 35 | The Importance of Delirium: Economic and Societal Costs | Journal of the American Geriatrics Society | 2011 | 312 |
| 36 | Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6 | Journal of Biological Chemistry | 1999 | 309 |
| 37 | Sleep, the hypothalamic–pituitary–adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders | Endocrinology and Metabolism Clinics of North America | 2002 | 309 |
| 38 | Calcium signalling in T cells | Nature Reviews Immunology | 2019 | 306 |
| 39 | Central distribution of subdiaphragmatic vagal branches in the rat | Journal of Comparative Neurology | 1988 | 299 |
| 40 | Neuronal organization of olfactory bulb circuits | Frontiers in Neural Circuits | 2014 | 297 |
| 41 | Mutant V599EB-Raf Regulates Growth and Vascular Development of Malignant Melanoma Tumors | Cancer Research | 2005 | 296 |
| 42 | The biology of the opioid growth factor receptor (OGFr) | Brain Research Reviews | 2002 | 293 |
| 43 | Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro☆ | Biomaterials | 2007 | 292 |
| 44 | Proteins, platelets, and blood coagulation at biomaterial interfaces | Colloids and Surfaces B: Biointerfaces | 2014 | 290 |
| 45 | Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus | Virology | 1973 | 289 |
| 46 | Protein Stability and Surface Electrostatics: A Charged Relationship† | Biochemistry | 2006 | 285 |
| 47 | Transforming Growth Factor β Activation of p44mapk in Proliferating Cultures of Epithelial Cells | Journal of Biological Chemistry | 1995 | 280 |
| 48 | An assembly domain of the Rous sarcoma virus Gag protein required late in budding | Journal of Virology | 1994 | 276 |
| 49 | Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents | Advances in Cancer Research | 1977 | 272 |
| 50 | Integrative detection and analysis of structural variation in cancer genomes | Nature Genetics | 2018 | 268 |
