| # | Title | Journal | Year | Citations |
|---|
| 1 | Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain | Journal of Pain | 2009 | 1,960 |
| 2 | Platelet-rich plasma: evidence to support its use | Journal of Oral and Maxillofacial Surgery | 2004 | 1,681 |
| 3 | Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? | Implant Dentistry | 2001 | 1,254 |
| 4 | A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction | Journal of the American College of Cardiology | 2009 | 1,205 |
| 5 | Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. | Stroke | 1989 | 1,136 |
| 6 | Chronic Pain-Associated Depression: Antecedent or Consequence of Chronic Pain? A Review | Clinical Journal of Pain | 1997 | 922 |
| 7 | Treatment Outcomes in the Tube Versus Trabeculectomy (TVT) Study After Five Years of Follow-up | American Journal of Ophthalmology | 2012 | 874 |
| 8 | The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes | Nature Genetics | 1997 | 863 |
| 9 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 10 | The Perioperative Management of Antithrombotic Therapy | Chest | 2008 | 763 |
| 11 | TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease | Annals of Neurology | 2007 | 753 |
| 12 | Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein | Science | 1999 | 689 |
| 13 | Postoperative Complications in the Tube Versus Trabeculectomy (TVT) Study During Five Years of Follow-up | American Journal of Ophthalmology | 2012 | 678 |
| 14 | Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells | Cancer Research | 2008 | 617 |
| 15 | Rodent models of cerebral ischemia. | Stroke | 1989 | 597 |
| 16 | Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1 | Nature | 1997 | 572 |
| 17 | Selective Trans-Splenic Decompression Of Gastroesophageal Varices By Distal Splenorenal Shunt | Annals of Surgery | 1967 | 559 |
| 18 | Identity and Agency in Emerging Adulthood | Youth and Society | 2005 | 519 |
| 19 | The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production | Journal of Cell Biology | 2007 | 510 |
| 20 | Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. | Journal of Immunology | 1993 | 497 |
| 21 | Spectrum of Microbial Keratitis in South Florida | American Journal of Ophthalmology | 1980 | 483 |
| 22 | Prenatal depression effects on the fetus and newborn: a review | | 2006 | 472 |
| 23 | A Randomized and Blinded Multicenter Trial of High‐Dose Fluconazole plus Placebo versus Fluconazole plus Amphotericin B as Therapy for Candidemia and Its Consequences in Nonneutropenic Subjects | Clinical Infectious Diseases | 2003 | 471 |
| 24 | Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium | FEBS Letters | 2006 | 461 |
| 25 | Movement of spermatocytes from the basal to the adluminal compartment of the rat testis | American Journal of Anatomy | 1977 | 455 |
| 26 | Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. | Journal of Cell Biology | 1996 | 437 |
| 27 | Nosocomial acute-onset postoperative endophthalmitis survey | Ophthalmology | 1998 | 431 |
| 28 | 2-Deoxy-d-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo | Cancer Research | 2004 | 414 |
| 29 | Size limit of molecules permeating the junctional membrane channels | Science | 1977 | 412 |
| 30 | Metformin reverses established lung fibrosis in a bleomycin model | Nature Medicine | 2018 | 411 |
| 31 | Macular Ganglion Cell–Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral Domain–Optical Coherence Tomography in Glaucoma | | 2011 | 384 |
| 32 | Epidemiology of puerperal fever: The contributions of Alexander Gordon | Medical History | 1993 | 382 |
| 33 | Decreased Accessibility and Lack of Activation of ErbB2 in JIMT-1, a Herceptin-Resistant, MUC4-Expressing Breast Cancer Cell Line | Cancer Research | 2005 | 378 |
| 34 | Neurones express high levels of a structurally modified, activated form of pp60c-src | Nature | 1985 | 376 |
| 35 | High Risk of HIV-Related Mortality Is Associated With Selenium Deficiency | Journal of Acquired Immune Deficiency Syndromes | 1997 | 362 |
| 36 | INCIDENCE, ETIOLOGY, LOCATION, PREVENTION AND TREATMENT OF POSITIVE SURGICAL MARGINS AFTER RADICAL PROSTATECTOMY FOR PROSTATE CANCER | Journal of Urology | 1998 | 357 |
| 37 | Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial | Lancet Neurology, The | 2012 | 354 |
| 38 | Three-Year Follow-up of the Tube Versus Trabeculectomy Study | American Journal of Ophthalmology | 2009 | 352 |
| 39 | Calcium-activated potassium channels | Trends in Neurosciences | 1987 | 344 |
| 40 | Titrating the Effects of Mitochondrial Complex I Impairment in the Cell Physiology | Journal of Biological Chemistry | 1999 | 342 |
| 41 | 5-Fluorouracil and Glaucoma Filtering Surgery | Ophthalmology | 1984 | 341 |
| 42 | Structure and function of human perforin | Nature | 1988 | 339 |
| 43 | Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor | Journal of Cell Biology | 1992 | 335 |
| 44 | Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation. | Radiology | 1993 | 327 |
| 45 | Permeability of cell junction depends on local cytoplasmic calcium activity | Nature | 1975 | 321 |
| 46 | Norepinephrine and GTP-γ-S increase myofilament Ca2+ sensitivity in α-toxin permeabilized arterial smooth muscle | Biochemical and Biophysical Research Communications | 1988 | 317 |
| 47 | Drug Abuse, Dependence, and Addiction in Chronic Pain Patients | Clinical Journal of Pain | 1992 | 313 |
| 48 | Rat ?-nerve growth factor sequence and site of synthesis in the adult hippocampus | Journal of Neuroscience Research | 1988 | 311 |
| 49 | Distribution of CGRP-, VIP-, D?H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat | Cell and Tissue Research | 1991 | 311 |
| 50 | Adaptive Increase in D3Dopamine Receptors in the Brain Reward Circuits of Human Cocaine Fatalities | Journal of Neuroscience | 1996 | 302 |
