| # | Title | Journal | Year | Citations |
|---|
| 1 | SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls | Nature | 2020 | 1,744 |
| 2 | Diagnosis, Prevention, and Treatment of Catheter-Associated Urinary Tract Infection in Adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 1,604 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak | Brain, Behavior, and Immunity | 2020 | 1,165 |
| 5 | Guillain–Barré Syndrome | New England Journal of Medicine | 2012 | 1,091 |
| 6 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 7 | Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study | Gastroenterology | 2021 | 913 |
| 8 | Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression | Journal of Affective Disorders | 2012 | 759 |
| 9 | Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity | Nature | 2017 | 743 |
| 10 | Big data and machine learning algorithms for health-care delivery | Lancet Oncology, The | 2019 | 733 |
| 11 | Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches | Science | 2019 | 676 |
| 12 | An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element | Science | 2014 | 665 |
| 13 | Epidemiology of COVID‐19: A systematic review and meta‐analysis of clinical characteristics, risk factors, and outcomes | Journal of Medical Virology | 2021 | 450 |
| 14 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 15 | Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men | Diabetologia | 2010 | 405 |
| 16 | Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency | Immunity | 2017 | 380 |
| 17 | A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci | Nature Genetics | 2010 | 374 |
| 18 | The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review | Gut | 2017 | 368 |
| 19 | The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals | Nature Genetics | 2016 | 362 |
| 20 | Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 1: Definition, risk factors and assessment | Journal of Gastroenterology and Hepatology (Australia) | 2018 | 358 |
| 21 | Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer | PLoS Genetics | 2009 | 354 |
| 22 | A global scientific strategy to cure hepatitis B | The Lancet Gastroenterology and Hepatology | 2019 | 342 |
| 23 | Fast and sensitive mapping of nanopore sequencing reads with GraphMap | Nature Communications | 2016 | 331 |
| 24 | Asia Pacific consensus recommendations for colorectal cancer screening | Gut | 2008 | 307 |
| 25 | Geographic Expansion of Dengue: The Impact of International Travel | Medical Clinics of North America | 2008 | 299 |
| 26 | Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia | Cell | 2011 | 292 |
| 27 | Choosing an animal model for the study of Huntington's disease | Nature Reviews Neuroscience | 2013 | 287 |
| 28 | Risk factors for lung cancer in singapore chinese, a population with high female incidence rates | International Journal of Cancer | 1977 | 274 |
| 29 | Serum autoantibodies as biomarkers for early cancer detection | FEBS Journal | 2009 | 272 |
| 30 | Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements) | Gut | 2020 | 264 |
| 31 | Role of the miR‐106b‐25 microRNA cluster in hepatocellular carcinoma | Cancer Science | 2009 | 262 |
| 32 | Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms | American Journal of Gastroenterology | 1998 | 258 |
| 33 | 2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis | Clinical Gastroenterology and Hepatology | 2022 | 255 |
| 34 | Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis | BMJ, The | 2022 | 253 |
| 35 | Characteristics and outcomes of culture-negative versus culture-positive severe sepsis | Critical Care | 2013 | 250 |
| 36 | Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls | Nature | 2019 | 248 |
| 37 | A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B | Nature Genetics | 2010 | 245 |
| 38 | Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis | Cell | 2010 | 245 |
| 39 | Axonal Guillain-Barré syndrome: concepts and controversies | Lancet Neurology, The | 2013 | 244 |
| 40 | Emergence of a new SARS-CoV-2 variant in the UK | Journal of Infection | 2021 | 241 |
| 41 | The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects | Gut | 2011 | 240 |
| 42 | The Human Bone Marrow Response to Acute Air Pollution Caused by Forest Fires | American Journal of Respiratory and Critical Care Medicine | 2000 | 239 |
| 43 | Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus | Gut | 2020 | 239 |
| 44 | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers | Free Radical Biology and Medicine | 2010 | 226 |
| 45 | GFR Estimating Equations in a Multiethnic Asian Population | American Journal of Kidney Diseases | 2011 | 225 |
| 46 | Right ventricular dysfunction in left‐sided heart failure with preserved versus reduced ejection fraction | European Journal of Heart Failure | 2017 | 224 |
| 47 | Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression | Rheumatology | 2010 | 221 |
| 48 | The rise of chronic non-communicable diseases in southeast Asia: time for action | Lancet, The | 2011 | 220 |
| 49 | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease | Nature Genetics | 2017 | 218 |
| 50 | Determinants of burnout and other aspects of psychological well-being in healthcare workers during the Covid-19 pandemic: A multinational cross-sectional study | PLoS ONE | 2021 | 215 |
