| # | Title | Journal | Year | Citations |
|---|
| 1 | Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents | Journal of the American College of Cardiology | 2008 | 523 |
| 2 | ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin | Clinical Pharmacology and Therapeutics | 2009 | 365 |
| 3 | Blockade of TNF-α rapidly inhibits pain responses in the central nervous system | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 308 |
| 4 | Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement | Journal of the American College of Cardiology | 2010 | 285 |
| 5 | IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice | Hepatology | 2007 | 234 |
| 6 | CYTOKINE EXPRESSION IN THREE MOUSE MODELS OF EXPERIMENTAL HEPATITIS | Cytokine | 2002 | 191 |
| 7 | Understanding platinum-induced ototoxicity | Trends in Pharmacological Sciences | 2013 | 183 |
| 8 | Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice | Journal of Clinical Investigation | 2001 | 178 |
| 9 | The Influence of Macrolide Antibiotics on the Uptake of Organic Anions and Drugs Mediated by OATP1B1 and OATP1B3 | Drug Metabolism and Disposition | 2007 | 175 |
| 10 | Silibinin protects mice from T cell-dependent liver injury☆ | Journal of Hepatology | 2003 | 160 |
| 11 | Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol‐associated adverse effects | Clinical Pharmacology and Therapeutics | 2002 | 154 |
| 12 | α-Galactosylceramide-Induced Liver Injury in Mice Is Mediated by TNF-α but Independent of Kupffer Cells | Journal of Immunology | 2005 | 153 |
| 13 | Transporter-mediated drug–drug interactions | Pharmacogenomics | 2011 | 148 |
| 14 | Antiviral Activity and Hepatoprotection by Heme Oxygenase-1 in Hepatitis B Virus Infection | Gastroenterology | 2007 | 143 |
| 15 | Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines | Hepatology | 2007 | 139 |
| 16 | Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1) | British Journal of Clinical Pharmacology | 2005 | 134 |
| 17 | Asymmetric and Symmetric Dimethylarginine as Risk Markers for Total Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies | PLoS ONE | 2016 | 131 |
| 18 | Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia | Blood | 2013 | 130 |
| 19 | Functionalization of carbon nanotubes enables non-covalent binding and intracellular delivery of small interfering RNA for efficient knock-down of genes | Biochemical and Biophysical Research Communications | 2008 | 127 |
| 20 | Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects | Clinical Pharmacology and Therapeutics | 2014 | 114 |
| 21 | Role of P-Glycoprotein Inhibition for Drug Interactions | Clinical Pharmacokinetics | 2007 | 101 |
| 22 | Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2) | Naunyn-Schmiedeberg's Archives of Pharmacology | 2009 | 101 |
| 23 | The flame retardants tetrabromobisphenol A and tetrabromobisphenol A–bisallylether suppress the induction of interleukin-2 receptor α chain (CD25) in murine splenocytes | Toxicology | 2003 | 99 |
| 24 | Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport | Drug Metabolism and Disposition | 2011 | 94 |
| 25 | Cellular and Cytokine-Mediated Mechanisms of Inflammation and its Modulation in Immune-Mediated Liver Injury | Zeitschrift Fur Gastroenterologie | 2007 | 93 |
| 26 | Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates | PLoS ONE | 2015 | 92 |
| 27 | Clinical Aspects of Transporter‐Mediated Drug–Drug Interactions | Clinical Pharmacology and Therapeutics | 2019 | 88 |
| 28 | Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice | International Journal of Cancer | 2008 | 87 |
| 29 | Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine | Biochemical Pharmacology | 2013 | 85 |
| 30 | Variability in human hepatic MRP4 expression: influence of cholestasis and genotype | Pharmacogenomics Journal | 2008 | 83 |
| 31 | Functional Characterization of the Human Organic Cation Transporter 2 Variant p.270Ala>Ser | Drug Metabolism and Disposition | 2009 | 80 |
| 32 | N1-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin–trimethoprim interaction | European Journal of Clinical Pharmacology | 2015 | 79 |
| 33 | Identification of Budesonide and Prednisone as Substrates of the Intestinal Drug Efflux Pump P-glycoprotein | Inflammatory Bowel Diseases | 2004 | 78 |
| 34 | Characterization of beta-adrenoceptor antagonists as substrates and inhibitors of the drug transporter P-glycoprotein1 | Fundamental and Clinical Pharmacology | 2006 | 75 |
| 35 | Neurokinin-1 Receptor Antagonists CP-96,345 and L-733,060 Protect Mice from Cytokine-Mediated Liver Injury | Journal of Pharmacology and Experimental Therapeutics | 2003 | 74 |
| 36 | Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell-surface Antigen-restricted Activation | Journal of Biological Chemistry | 2003 | 70 |
| 37 | The candy smell test: A New Test for Retronasal Olfactory Performance | Laryngoscope | 2009 | 68 |
| 38 | 3D engineered heart tissue for replacement therapy | Basic Research in Cardiology | 2002 | 64 |
| 39 | Molecular Mechanism of Renal Tubular Secretion of the Antimalarial Drug Chloroquine | Antimicrobial Agents and Chemotherapy | 2011 | 64 |
| 40 | Inhibitory Effects of Green Tea and (–)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein | PLoS ONE | 2015 | 64 |
| 41 | Protection against Progressive Leishmaniasis by IFN-β | Journal of Immunology | 2004 | 62 |
| 42 | Inhibition of hepatic uptake transporters by flavonoids | European Journal of Pharmaceutical Sciences | 2012 | 59 |
| 43 | Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple‐transfected MDCK‐OATP1B1‐UGT1A1‐MRP2 cells | British Journal of Pharmacology | 2012 | 57 |
| 44 | Dimethylarginine Dimethylaminohydrolase Overexpression Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Lowering Asymmetric Dimethylarginine | American Journal of Pathology | 2010 | 55 |
| 45 | Adverse drug events in patients admitted to an emergency department: an analysis of direct costs | Pharmacoepidemiology and Drug Safety | 2015 | 55 |
| 46 | Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1) | Journal of Molecular and Cellular Cardiology | 2012 | 52 |
| 47 | Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure | Biochemical and Biophysical Research Communications | 2008 | 50 |
| 48 | The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice | Journal of Hepatology | 2009 | 50 |
| 49 | Anticholinergic burden and cognitive function in a large German cohort of hospitalized geriatric patients | PLoS ONE | 2017 | 50 |
| 50 | 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4 | Human Mutation | 2008 | 46 |
