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#TitleJournalYearCitations
117β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor developmentJournal of Steroid Biochemistry and Molecular Biology2011181
2Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosaChemistry and Biology2012110
3Metal-Mediated Inhibition ofEscherichiacoliMethionine Aminopeptidase:  Structure−Activity Relationships and Development of a Novel Scoring Function for Metal−Ligand InteractionsJournal of Medicinal Chemistry2006100
4Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)Journal of Medicinal Chemistry200899
5Effects of novel 17α-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivoJournal of Steroid Biochemistry and Molecular Biology200395
6Synthesis and Evaluation of Heteroaryl-Substituted Dihydronaphthalenes and Indenes:  Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) for the Treatment of Congestive Heart Failure and Myocardial FibrosisJournal of Medicinal Chemistry200691
7Synthesis and Evaluation of Novel Steroidal Oxime Inhibitors of P450 17 (17α-Hydroxylase/C17−20-Lyase) and 5α-Reductase Types 1 and 2Journal of Medicinal Chemistry200084
8Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cellsJournal of Steroid Biochemistry and Molecular Biology200278
9Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Aromatase Inhibitors Selective over 17-α-Hydroxylase/C17−20 LyaseJournal of Medicinal Chemistry201178
10Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structureBioorganic and Medicinal Chemistry200876
11Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent DiseasesJournal of Medicinal Chemistry200876
12In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1H-quinolin-2-one DerivativesJournal of Medicinal Chemistry200873
133,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of 2Z with PDK1: 3HRF.Journal of Medicinal Chemistry200972
14New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and SelectivityJournal of Medicinal Chemistry200970
15Heteroaryl-Substituted Naphthalenes and Structurally Modified Derivatives:  Selective Inhibitors of CYP11B2 for the Treatment of Congestive Heart Failure and Myocardial FibrosisJournal of Medicinal Chemistry200569
16Prediction of Protein−Protein Interaction Inhibitors by Chemoinformatics and Machine Learning MethodsJournal of Medicinal Chemistry200769
17Synthesis, Biological Evaluation, and Molecular Modeling of Abiraterone Analogues: Novel CYP17 Inhibitors for the Treatment of Prostate CancerJournal of Medicinal Chemistry200869
18Isopropylidene Substitution Increases Activity and Selectivity of Biphenylmethylene 4-Pyridine Type CYP17 InhibitorsJournal of Medicinal Chemistry201069
19Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design ApproachJournal of Medicinal Chemistry200868
20Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenylsEuropean Journal of Medicinal Chemistry200963
21Synthesis of Hydroxy Derivatives of Highly Potent Non-steroidal CYP 17 Inhibitors as Potential Metabolites and Evaluation of their Activity by a Non Cellular Assay using Recombinant Human EnzymeJournal of Enzyme Inhibition and Medicinal Chemistry200462
22Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseasesBioorganic and Medicinal Chemistry200861
23First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent DiseasesACS Medicinal Chemistry Letters201161
24Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one DerivativesJournal of Medicinal Chemistry201160
25Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and PharmacokineticsJournal of Medicinal Chemistry200859
26A novel approach towards calibrated measurement of trace gases using metal oxide semiconductor sensorsSensors and Actuators B: Chemical201759
27Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridgeBioorganic and Medicinal Chemistry200858
28Inhibition of CYP 17, a New Strategy for the Treatment of Prostate CancerArchiv Der Pharmazie200257
29Cushing’s Syndrome: Development of Highly Potent and Selective CYP11B1 Inhibitors of the (Pyridylmethyl)pyridine TypeJournal of Medicinal Chemistry201353
30Novel Highly Potent and Selective Nonsteroidal Aromatase Inhibitors: Synthesis, Biological Evaluation and Structure−Activity Relationships InvestigationJournal of Medicinal Chemistry201052
31Structure Optimization of 2-Benzamidobenzoic Acids as PqsD Inhibitors for Pseudomonas aeruginosa Infections and Elucidation of Binding Mode by SPR, STD NMR, and Molecular DockingJournal of Medicinal Chemistry201352
32Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast CancerJournal of Medicinal Chemistry201251
33Tetrahydropyrroloquinolinone Type Dual Inhibitors of Aromatase/Aldosterone Synthase as a Novel Strategy for Breast Cancer Patients with Elevated Cardiovascular RisksJournal of Medicinal Chemistry201351
34Replacement of Imidazolyl by Pyridyl in Biphenylmethylenes Results in Selective CYP17 and Dual CYP17/CYP11B1 Inhibitors for the Treatment of Prostate CancerJournal of Medicinal Chemistry201050
35New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent DiseasesJournal of Medicinal Chemistry201150
36Functional esterase surface display by the autotransporter pathway in Escherichia coliJournal of Molecular Catalysis B: Enzymatic200249
375-Phenyl substituted 1-methyl-2-pyridones and 4′-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5α-reductase type 1 and 2Bioorganic and Medicinal Chemistry200249
38In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor TreatmentFrontiers in Microbiology201749
39Novel Pyridyl- or Isoquinolinyl-Substituted Indolines and Indoles as Potent and Selective Aldosterone Synthase InhibitorsJournal of Medicinal Chemistry201448
40Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and SelectivityJournal of Medicinal Chemistry200846
41Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure–activity relationshipsEuropean Journal of Medicinal Chemistry201446
42Development of a biological screening system for the evaluation of highly active and selective 17β-HSD1-inhibitors as potential therapeutic agentsMolecular and Cellular Endocrinology200945
43Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate CancerInternational Journal of Molecular Sciences201345
44Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapyMedicinal Chemistry Research201143
45Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant ProteinsJournal of Medicinal Chemistry201741
4617β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffoldBioorganic and Medicinal Chemistry201140
47Highly Potent and Selective Nonsteroidal Dual Inhibitors of CYP17/CYP11B2 for the Treatment of Prostate Cancer To Reduce Risks of Cardiovascular DiseasesJournal of Medicinal Chemistry201340
48Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4ACS Medicinal Chemistry Letters201440
49Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase InhibitionJournal of Medicinal Chemistry201339
50Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosaEuropean Journal of Medicinal Chemistry201539