# | Title | Journal | Year | Citations |
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1 | 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development | Journal of Steroid Biochemistry and Molecular Biology | 2011 | 181 |
2 | Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa | Chemistry and Biology | 2012 | 110 |
3 | Metal-Mediated Inhibition ofEscherichiacoliMethionine Aminopeptidase: Structure−Activity Relationships and Development of a Novel Scoring Function for Metal−Ligand Interactions | Journal of Medicinal Chemistry | 2006 | 100 |
4 | Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) | Journal of Medicinal Chemistry | 2008 | 99 |
5 | Effects of novel 17α-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo | Journal of Steroid Biochemistry and Molecular Biology | 2003 | 95 |
6 | Synthesis and Evaluation of Heteroaryl-Substituted Dihydronaphthalenes and Indenes: Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) for the Treatment of Congestive Heart Failure and Myocardial Fibrosis | Journal of Medicinal Chemistry | 2006 | 91 |
7 | Synthesis and Evaluation of Novel Steroidal Oxime Inhibitors of P450 17 (17α-Hydroxylase/C17−20-Lyase) and 5α-Reductase Types 1 and 2 | Journal of Medicinal Chemistry | 2000 | 84 |
8 | Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells | Journal of Steroid Biochemistry and Molecular Biology | 2002 | 78 |
9 | Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Aromatase Inhibitors Selective over 17-α-Hydroxylase/C17−20 Lyase | Journal of Medicinal Chemistry | 2011 | 78 |
10 | Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure | Bioorganic and Medicinal Chemistry | 2008 | 76 |
11 | Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases | Journal of Medicinal Chemistry | 2008 | 76 |
12 | In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1H-quinolin-2-one Derivatives | Journal of Medicinal Chemistry | 2008 | 73 |
13 | 3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of 2Z with PDK1: 3HRF. | Journal of Medicinal Chemistry | 2009 | 72 |
14 | New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity | Journal of Medicinal Chemistry | 2009 | 70 |
15 | Heteroaryl-Substituted Naphthalenes and Structurally Modified Derivatives: Selective Inhibitors of CYP11B2 for the Treatment of Congestive Heart Failure and Myocardial Fibrosis | Journal of Medicinal Chemistry | 2005 | 69 |
16 | Prediction of Protein−Protein Interaction Inhibitors by Chemoinformatics and Machine Learning Methods | Journal of Medicinal Chemistry | 2007 | 69 |
17 | Synthesis, Biological Evaluation, and Molecular Modeling of Abiraterone Analogues: Novel CYP17 Inhibitors for the Treatment of Prostate Cancer | Journal of Medicinal Chemistry | 2008 | 69 |
18 | Isopropylidene Substitution Increases Activity and Selectivity of Biphenylmethylene 4-Pyridine Type CYP17 Inhibitors | Journal of Medicinal Chemistry | 2010 | 69 |
19 | Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach | Journal of Medicinal Chemistry | 2008 | 68 |
20 | Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls | European Journal of Medicinal Chemistry | 2009 | 63 |
21 | Synthesis of Hydroxy Derivatives of Highly Potent Non-steroidal CYP 17 Inhibitors as Potential Metabolites and Evaluation of their Activity by a Non Cellular Assay using Recombinant Human Enzyme | Journal of Enzyme Inhibition and Medicinal Chemistry | 2004 | 62 |
22 | Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases | Bioorganic and Medicinal Chemistry | 2008 | 61 |
23 | First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases | ACS Medicinal Chemistry Letters | 2011 | 61 |
24 | Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives | Journal of Medicinal Chemistry | 2011 | 60 |
25 | Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics | Journal of Medicinal Chemistry | 2008 | 59 |
26 | A novel approach towards calibrated measurement of trace gases using metal oxide semiconductor sensors | Sensors and Actuators B: Chemical | 2017 | 59 |
27 | Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge | Bioorganic and Medicinal Chemistry | 2008 | 58 |
28 | Inhibition of CYP 17, a New Strategy for the Treatment of Prostate Cancer | Archiv Der Pharmazie | 2002 | 57 |
29 | Cushing’s Syndrome: Development of Highly Potent and Selective CYP11B1 Inhibitors of the (Pyridylmethyl)pyridine Type | Journal of Medicinal Chemistry | 2013 | 53 |
30 | Novel Highly Potent and Selective Nonsteroidal Aromatase Inhibitors: Synthesis, Biological Evaluation and Structure−Activity Relationships Investigation | Journal of Medicinal Chemistry | 2010 | 52 |
31 | Structure Optimization of 2-Benzamidobenzoic Acids as PqsD Inhibitors for Pseudomonas aeruginosa Infections and Elucidation of Binding Mode by SPR, STD NMR, and Molecular Docking | Journal of Medicinal Chemistry | 2013 | 52 |
32 | Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer | Journal of Medicinal Chemistry | 2012 | 51 |
33 | Tetrahydropyrroloquinolinone Type Dual Inhibitors of Aromatase/Aldosterone Synthase as a Novel Strategy for Breast Cancer Patients with Elevated Cardiovascular Risks | Journal of Medicinal Chemistry | 2013 | 51 |
34 | Replacement of Imidazolyl by Pyridyl in Biphenylmethylenes Results in Selective CYP17 and Dual CYP17/CYP11B1 Inhibitors for the Treatment of Prostate Cancer | Journal of Medicinal Chemistry | 2010 | 50 |
35 | New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases | Journal of Medicinal Chemistry | 2011 | 50 |
36 | Functional esterase surface display by the autotransporter pathway in Escherichia coli | Journal of Molecular Catalysis B: Enzymatic | 2002 | 49 |
37 | 5-Phenyl substituted 1-methyl-2-pyridones and 4′-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5α-reductase type 1 and 2 | Bioorganic and Medicinal Chemistry | 2002 | 49 |
38 | In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment | Frontiers in Microbiology | 2017 | 49 |
39 | Novel Pyridyl- or Isoquinolinyl-Substituted Indolines and Indoles as Potent and Selective Aldosterone Synthase Inhibitors | Journal of Medicinal Chemistry | 2014 | 48 |
40 | Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity | Journal of Medicinal Chemistry | 2008 | 46 |
41 | Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure–activity relationships | European Journal of Medicinal Chemistry | 2014 | 46 |
42 | Development of a biological screening system for the evaluation of highly active and selective 17β-HSD1-inhibitors as potential therapeutic agents | Molecular and Cellular Endocrinology | 2009 | 45 |
43 | Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer | International Journal of Molecular Sciences | 2013 | 45 |
44 | Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy | Medicinal Chemistry Research | 2011 | 43 |
45 | Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins | Journal of Medicinal Chemistry | 2017 | 41 |
46 | 17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold | Bioorganic and Medicinal Chemistry | 2011 | 40 |
47 | Highly Potent and Selective Nonsteroidal Dual Inhibitors of CYP17/CYP11B2 for the Treatment of Prostate Cancer To Reduce Risks of Cardiovascular Diseases | Journal of Medicinal Chemistry | 2013 | 40 |
48 | Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4 | ACS Medicinal Chemistry Letters | 2014 | 40 |
49 | Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition | Journal of Medicinal Chemistry | 2013 | 39 |
50 | Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa | European Journal of Medicinal Chemistry | 2015 | 39 |