| # | Title | Journal | Year | Citations |
|---|
| 1 | ESPEN guidelines on definitions and terminology of clinical nutrition | Clinical Nutrition | 2017 | 1,451 |
| 2 | Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial | Lancet, The | 2008 | 1,269 |
| 3 | Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus | Endocrine Reviews | 2016 | 1,172 |
| 4 | Dickkopf-1 is a master regulator of joint remodeling | Nature Medicine | 2007 | 1,161 |
| 5 | Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) | Nature Reviews Gastroenterology and Hepatology | 2016 | 964 |
| 6 | EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update | Annals of the Rheumatic Diseases | 2017 | 918 |
| 7 | New therapies for treatment of rheumatoid arthritis | Lancet, The | 2007 | 859 |
| 8 | Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2017 | 831 |
| 9 | Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial | Lancet, The | 2016 | 771 |
| 10 | The interaction of hepatic lipid and glucose metabolism in liver diseases | Journal of Hepatology | 2012 | 728 |
| 11 | The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response | Immunity | 2008 | 687 |
| 12 | NASH limits anti-tumour surveillance in immunotherapy-treated HCC | Nature | 2021 | 649 |
| 13 | Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial | Lancet, The | 2017 | 633 |
| 14 | Bile acid receptors as targets for drug development | Nature Reviews Gastroenterology and Hepatology | 2014 | 565 |
| 15 | Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines | Journal of Crohn's and Colitis | 2013 | 541 |
| 16 | Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial | Lancet Oncology, The | 2022 | 526 |
| 17 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2013 | 498 |
| 18 | Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS | Intensive Care Medicine | 2013 | 474 |
| 19 | Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease | Nature Reviews Nephrology | 2018 | 473 |
| 20 | Sleeve Gastrectomy as Sole and Definitive Bariatric Procedure: 5-Year Results for Weight Loss and Ghrelin | Obesity Surgery | 2010 | 455 |
| 21 | Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives | Hepatology | 2017 | 444 |
| 22 | Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production | International Journal of Obesity | 2007 | 436 |
| 23 | Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial | Annals of the Rheumatic Diseases | 2009 | 424 |
| 24 | New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond | Journal of Hepatology | 2015 | 406 |
| 25 | Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation | Cancer Cell | 2010 | 405 |
| 26 | Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 395 |
| 27 | Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease | Annual Review of Pathology: Mechanisms of Disease | 2018 | 387 |
| 28 | The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm | Journal of Viral Hepatitis | 2014 | 372 |
| 29 | The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response? | American Journal of Gastroenterology | 2011 | 356 |
| 30 | Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis | Gastroenterology | 2017 | 355 |
| 31 | Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn’s Disease | Gastroenterology | 2018 | 331 |
| 32 | Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability | Diabetes | 2005 | 320 |
| 33 | Targeting the gut-liver axis in liver disease | Journal of Hepatology | 2017 | 311 |
| 34 | Bile acid transporters and regulatory nuclear receptors in the liver and beyond | Journal of Hepatology | 2013 | 304 |
| 35 | Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development | Toxicological Sciences | 2010 | 302 |
| 36 | Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 300 |
| 37 | Temporal Bacterial Community Dynamics Vary Among Ulcerative Colitis Patients After Fecal Microbiota Transplantation | American Journal of Gastroenterology | 2013 | 298 |
| 38 | Prospective Age-Matching in Elderly Kidney Transplant Recipients—A 5-Year Analysis of the Eurotransplant Senior Program | American Journal of Transplantation | 2008 | 291 |
| 39 | Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis | Annals of the Rheumatic Diseases | 2005 | 287 |
| 40 | CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity | Journal of Clinical Endocrinology and Metabolism | 2008 | 283 |
| 41 | Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update | Annals of the Rheumatic Diseases | 2016 | 275 |
| 42 | TNF-induced structural joint damage is mediated by IL-1 | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 273 |
| 43 | Pathophysiological mechanisms of liver injury in COVID‐19 | Liver International | 2021 | 273 |
| 44 | Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment | Gut | 2014 | 267 |
| 45 | Depletion of Endothelial Progenitor Cells in the Peripheral Blood of Patients With Rheumatoid Arthritis | Circulation | 2005 | 265 |
| 46 | Increased Plasma Visfatin Concentrations in Morbidly Obese Subjects Are Reduced after Gastric Banding | Journal of Clinical Endocrinology and Metabolism | 2006 | 265 |
| 47 | Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids | Diabetologia | 2006 | 264 |
| 48 | Adipose tissue macrophages | Immunology Letters | 2007 | 261 |
| 49 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2020 | Endoscopy | 2020 | 255 |
| 50 | PONTIAC (NT-proBNP Selected PreventiOn of cardiac eveNts in a populaTion of dIabetic patients without A history of Cardiac disease) | Journal of the American College of Cardiology | 2013 | 253 |
