# | Title | Journal | Year | Citations |
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1 | The Inflammasomes | Cell | 2010 | 4,781 |
2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
3 | Gout-associated uric acid crystals activate the NALP3 inflammasome | Nature | 2006 | 4,427 |
4 | A role for mitochondria in NLRP3 inflammasome activation | Nature | 2011 | 4,234 |
5 | Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 | Cell Death and Differentiation | 2009 | 2,572 |
6 | Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica | Science | 2008 | 2,289 |
7 | Thioredoxin-interacting protein links oxidative stress to inflammasome activation | Nature Immunology | 2010 | 2,163 |
8 | Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus | Nature | 2005 | 2,136 |
9 | The Inflammasomes: Guardians of the Body | Annual Review of Immunology | 2009 | 2,082 |
10 | Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors | Nature Medicine | 2009 | 1,614 |
11 | NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder | Immunity | 2004 | 1,566 |
12 | NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? | Nature Reviews Immunology | 2010 | 1,495 |
13 | Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration | Cell Death and Differentiation | 2007 | 1,222 |
14 | Intracellular pattern recognition receptors in the host response | Nature | 2006 | 1,051 |
15 | IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis | Cell | 2007 | 993 |
16 | The NLRP3 Inflammasome: A Sensor for Metabolic Danger? | Science | 2010 | 956 |
17 | Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy | Immunity | 2019 | 924 |
18 | The gasdermins, a protein family executing cell death and inflammation | Nature Reviews Immunology | 2020 | 881 |
19 | Inflammatory Caspases | Cell | 2004 | 866 |
20 | The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response | Nature | 2008 | 838 |
21 | Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation | Immunity | 2011 | 810 |
22 | Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells | Nature Immunology | 2007 | 809 |
23 | Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence | Nature | 2009 | 799 |
24 | RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation | Nature Immunology | 2004 | 744 |
25 | Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation | Journal of Biological Chemistry | 2011 | 723 |
26 | Inflammatory caspases and inflammasomes: master switches of inflammation | Cell Death and Differentiation | 2007 | 718 |
27 | Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome | Gut | 2010 | 687 |
28 | The inflammasome: an integrated view | Immunological Reviews | 2011 | 683 |
29 | The inflammasome: a danger sensing complex triggering innate immunity | Current Opinion in Immunology | 2007 | 640 |
30 | Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans | Nature Genetics | 2005 | 620 |
31 | Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes | Cell Death and Differentiation | 2009 | 599 |
32 | Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation | Immunity | 2013 | 597 |
33 | The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress | Science | 2004 | 591 |
34 | NLRs join TLRs as innate sensors of pathogens | Trends in Immunology | 2005 | 579 |
35 | Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome | Journal of Immunology | 2008 | 548 |
36 | Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells | Immunity | 2010 | 544 |
37 | Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome | Current Biology | 2004 | 512 |
38 | Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 486 |
39 | Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production | Nature Immunology | 2010 | 477 |
40 | Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients | Science | 2013 | 474 |
41 | Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 470 |
42 | ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation | Science | 2018 | 466 |
43 | Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response | Journal of Histochemistry and Cytochemistry | 2007 | 438 |
44 | Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains | Science | 2016 | 438 |
45 | A unique signature identifies a family of zinc-dependent metallopeptidases | FEBS Letters | 1989 | 435 |
46 | Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation | Immunity | 2012 | 430 |
47 | Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1 | Immunity | 2012 | 427 |
48 | Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps | Science Immunology | 2018 | 425 |
49 | CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons | Journal of Neuroscience | 1999 | 406 |
50 | STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 404 |