| # | Title | Journal | Year | Citations |
|---|
| 1 | Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants | Nature Reviews Microbiology | 2020 | 1,427 |
| 2 | Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species | Immunity | 2019 | 897 |
| 3 | Origins and Evolution of the Global RNA Virome | MBio | 2018 | 383 |
| 4 | KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer | Cancers | 2017 | 193 |
| 5 | SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation | Bioinformatics | 2019 | 191 |
| 6 | Validation of the Crystallography Open Database using the Crystallographic Information Framework | Journal of Applied Crystallography | 2021 | 179 |
| 7 | Expanding functional protein sequence spaces using generative adversarial networks | Nature Machine Intelligence | 2021 | 165 |
| 8 | Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms | Nature Communications | 2019 | 160 |
| 9 | Doubling of the known set of RNA viruses by metagenomic analysis of an aquatic virome | Nature Microbiology | 2020 | 156 |
| 10 | The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame? | Nutrients | 2021 | 130 |
| 11 | Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids | Nature Communications | 2019 | 127 |
| 12 | Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease | Nature | 2021 | 125 |
| 13 | Cressdnaviricota : a Virus Phylum Unifying Seven Families of Rep-Encoding Viruses with Single-Stranded, Circular DNA Genomes | Journal of Virology | 2020 | 118 |
| 14 | An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing | Molecular Cell | 2019 | 109 |
| 15 | Blind prediction of homo‐ and hetero‐protein complexes: The CASP13‐CAPRI experiment | Proteins: Structure, Function and Bioinformatics | 2019 | 99 |
| 16 | Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia | Journal of Neurochemistry | 2020 | 91 |
| 17 | Microbial lipolytic enzymes – promising energy-efficient biocatalysts in bioremediation | Energy | 2020 | 85 |
| 18 | Estimation of model accuracy in CASP13 | Proteins: Structure, Function and Bioinformatics | 2019 | 78 |
| 19 | Structural biology of CRISPR–Cas immunity and genome editing enzymes | Nature Reviews Microbiology | 2022 | 78 |
| 20 | Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor | Nature Biomedical Engineering | 2021 | 77 |
| 21 | Microbial Diversity and Antimicrobial Resistance Profile in Microbiota From Soils of Conventional and Organic Farming Systems | Frontiers in Microbiology | 2019 | 76 |
| 22 | Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 75 |
| 23 | Binding affinity in drug design: experimental and computational techniques | Expert Opinion on Drug Discovery | 2019 | 75 |
| 24 | The Essentials of Marine Biotechnology | Frontiers in Marine Science | 2021 | 75 |
| 25 | Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment | Proteins: Structure, Function and Bioinformatics | 2021 | 73 |
| 26 | Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature | Frontiers in Bioengineering and Biotechnology | 2020 | 68 |
| 27 | A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage | Nature Cell Biology | 2019 | 67 |
| 28 | Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense | Nucleic Acids Research | 2020 | 66 |
| 29 | Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils | Cell Reports | 2020 | 65 |
| 30 | Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion | Nature Microbiology | 2022 | 64 |
| 31 | In vitro comparison of 3D printed polylactic acid/hydroxyapatite and polylactic acid/bioglass composite scaffolds: Insights into materials for bone regeneration | Journal of the Mechanical Behavior of Biomedical Materials | 2020 | 62 |
| 32 | Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells | Leukemia and Lymphoma | 2018 | 60 |
| 33 | Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging | Nature Communications | 2018 | 59 |
| 34 | New Insights Into Targeting Membrane Lipids for Cancer Therapy | Frontiers in Cell and Developmental Biology | 2020 | 58 |
| 35 | Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis | Nature Communications | 2019 | 55 |
| 36 | Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells | Nature Communications | 2021 | 53 |
| 37 | Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116 | Journal of Cellular Biochemistry | 2018 | 52 |
| 38 | Diversity and evolution of B-family DNA polymerases | Nucleic Acids Research | 2020 | 52 |
| 39 | Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion | Nature Microbiology | 2022 | 52 |
| 40 | Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions | Nature Communications | 2021 | 51 |
| 41 | Assessment of the morphology and dimensional accuracy of 3D printed PLA and PLA/HAp scaffolds | Journal of the Mechanical Behavior of Biomedical Materials | 2020 | 49 |
| 42 | Visual adaptations of diurnal and nocturnal raptors | Seminars in Cell and Developmental Biology | 2020 | 47 |
| 43 | Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy | Science Immunology | 2021 | 47 |
| 44 | Surface-Related Features and Virulence Among Acinetobacter baumannii Clinical Isolates Belonging to International Clones I and II | Frontiers in Microbiology | 2018 | 46 |
| 45 | Indole Biodegradation in Acinetobacter sp. Strain O153: Genetic and Biochemical Characterization | Applied and Environmental Microbiology | 2017 | 45 |
| 46 | Diversity, taxonomy, and evolution of archaeal viruses of the class Caudoviricetes | PLoS Biology | 2021 | 44 |
| 47 | Isothermal titration calorimetry for drug design: Precision of the enthalpy and binding constant measurements and comparison of the instruments | Analytical Biochemistry | 2016 | 43 |
| 48 | Asbestos‐associated genome‐wide DNA methylation changes in lung cancer | International Journal of Cancer | 2017 | 42 |
| 49 | Cell-Free DNA Modification Dynamics in Abiraterone Acetate-Treated Prostate Cancer Patients | Clinical Cancer Research | 2018 | 41 |
| 50 | Does the use of hormonal contraceptives affect the mental rotation performance? | Hormones and Behavior | 2018 | 40 |
