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Top Articles

#TitleJournalYearCitations
1Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,122
2Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy20211,430
3Mutational signatures associated with tobacco smoking in human cancerScience2016842
4Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's diseaseNature Genetics2010595
5The Relationship Between Online Game Addiction and Aggression, Self-Control and Narcissistic Personality TraitsEuropean Psychiatry2008514
6The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesisProceedings of the National Academy of Sciences of the United States of America2010416
7Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsyNature Medicine2015406
8Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC MutagenesisCell2019298
9Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionNature Genetics2020275
10Immune responses and immunopathology in acute and chronic viral hepatitisNature Reviews Immunology2016263
11Comprehensive molecular characterization of mitochondrial genomes in human cancersNature Genetics2020256
12Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasisJournal of Cell Biology2017250
13Biological functions of lymphatic vesselsScience2020220
14Association Between Expression Level of PD1 by Tumor-Infiltrating CD8+ T Cells and Features of Hepatocellular CarcinomaGastroenterology2018211
15A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress responseNature Communications2014209
16Hyperprogressive disease during PD-1/PD-L1 blockade in patients with non-small-cell lung cancerAnnals of Oncology2019205
17Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activationEMBO Journal2016201
18Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2Cell Stem Cell2020195
19Regulation of systemic energy homeostasis by serotonin in adipose tissuesNature Communications2015187
20Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherinJournal of Experimental Medicine2015172
21Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassaysJournal of Translational Medicine2011171
22Signal transducer and activator of transcription 3‐mediated CD133 up‐regulation contributes to promotion of hepatocellular carcinomaHepatology2015165
23Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complexNature Communications2017164
24Exosome‐mediated activation of toll‐like receptor 3 in stellate cells stimulates interleukin‐17 production by γδ T cells in liver fibrosisHepatology2016163
25Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesisNature Communications2016159
26YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant MelanomaCancer Immunology Research2018158
27Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working MemoryNeuron2016155
28Tracing Oncogene Rearrangements in the Mutational History of Lung AdenocarcinomaCell2019153
29Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle traffickingNature Communications2015151
30VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancersScience Immunology2019148
31CCDC41 is required for ciliary vesicle docking to the mother centrioleProceedings of the National Academy of Sciences of the United States of America2013145
32Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis AImmunity2018144
33Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancyProceedings of the National Academy of Sciences of the United States of America2013136
34The First-week Proliferative Response of Peripheral Blood PD-1+CD8+ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid TumorsClinical Cancer Research2019134
35Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortalityScience Advances2020132
36Resilience buffers the impact of traumatic events on the development of PTSD symptoms in firefightersJournal of Affective Disorders2014130
37Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant miceNature Neuroscience2018128
38Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasisNature Medicine2014127
39Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA BindingMolecular Cell2015126
40Neopepsee: accurate genome-level prediction of neoantigens by harnessing sequence and amino acid immunogenicity informationAnnals of Oncology2018126
41Defective mitochondrial fission augments NLRP3 inflammasome activationScientific Reports2015125
42Lung Myeloid Dendritic Cells Coordinately Induce T H 1 and T H 17 Responses in Human EmphysemaScience Translational Medicine2009124
43Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in miceHepatology2011124
44Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinomaJournal of Hepatology2021122
45VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formationNature Communications2013120
46Reduced oxidative capacity in macrophages results in systemic insulin resistanceNature Communications2018114
47Angiopoietin-1 Guides Directional Angiogenesis Through Integrin α v β 5 Signaling for Recovery of Ischemic RetinopathyScience Translational Medicine2013113
48Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdownJCI Insight2017113
49Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Enhanced Antigen Presentation of Dendritic CellACS Nano2019113
50Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular DisruptionCancer Cell2014109