| # | Title | Journal | Year | Citations |
|---|
| 1 | The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract | Nature | 1998 | 1,423 |
| 2 | A novel class of small RNAs bind to MILI protein in mouse testes | Nature | 2006 | 1,303 |
| 3 | Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes | Nature | 2008 | 1,007 |
| 4 | Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer | Cell | 2002 | 957 |
| 5 | DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes | Genes and Development | 2008 | 790 |
| 6 | Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors | Gastroenterology | 2003 | 653 |
| 7 | PGC7/Stella protects against DNA demethylation in early embryogenesis | Nature Cell Biology | 2007 | 493 |
| 8 | PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos | Nature | 2012 | 397 |
| 9 | Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses | Immunity | 2007 | 340 |
| 10 | Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells | Oncogene | 2006 | 312 |
| 11 | A Broadly Conserved Pathway Generates 3′UTR-Directed Primary piRNAs | Current Biology | 2009 | 304 |
| 12 | iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS | Science | 2012 | 292 |
| 13 | Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages | Nature | 2013 | 285 |
| 14 | The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin | Journal of Biological Chemistry | 1999 | 283 |
| 15 | Transcriptional regulation of osteopontin gene in vivo by PEBP2αA/CBFA1 and ETS1 in the skeletal tissues | Oncogene | 1998 | 263 |
| 16 | Akt mediates self-renewal division of mouse spermatogonial stem cells | Development (Cambridge) | 2007 | 234 |
| 17 | Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα | Oncogene | 1999 | 194 |
| 18 | Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients | Journal of Pathology | 2004 | 188 |
| 19 | Oncogenic protein tyrosine kinases | Cellular and Molecular Life Sciences | 2004 | 180 |
| 20 | A new type of hepatitis C virus in patients in Thailand | Biochemical and Biophysical Research Communications | 1992 | 172 |
| 21 | Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 | Nature Medicine | 2011 | 170 |
| 22 | Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice | Blood | 1996 | 167 |
| 23 | A role for heterologous gap junctions between melanoma and endothelial cells in metastasis | Journal of Clinical Investigation | 2000 | 167 |
| 24 | Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways | Development (Cambridge) | 2011 | 151 |
| 25 | Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities | EMBO Journal | 2005 | 149 |
| 26 | An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma | Cancer | 1992 | 144 |
| 27 | Comparative Detection of Lymph Node Micrometastases of Stage II Colorectal Cancer by Reverse Transcriptase Polymerase Chain Reaction and Immunohistochemistry | Journal of Clinical Oncology | 2002 | 136 |
| 28 | Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery | Oncogene | 2001 | 134 |
| 29 | Cancer risk after renal transplantation in Japan | International Journal of Cancer | 1997 | 133 |
| 30 | Molecular Cloning of a Novel Human Collectin from Liver (CL-L1) | Journal of Biological Chemistry | 1999 | 126 |
| 31 | Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer | British Journal of Cancer | 2007 | 123 |
| 32 | JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis | Gastroenterology | 2003 | 119 |
| 33 | Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy | ELife | 2018 | 118 |
| 34 | Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm | Hepatology | 2001 | 116 |
| 35 | Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals | Nature Communications | 2016 | 114 |
| 36 | CUBIC pathology: three-dimensional imaging for pathological diagnosis | Scientific Reports | 2017 | 110 |
| 37 | Gastrointestinal stromal tumors (GIST): A model for molecule-based diagnosis and treatment of solid tumors | Cancer Science | 2003 | 98 |
| 38 | PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation | Genes To Cells | 2008 | 97 |
| 39 | Expression of human immunodeficiency virus type 1 (HIV-1) gag antigens on the surface of a cell line persistently infected with HIV-1 that highly expresses HIV-1 antigens | Virology | 1989 | 95 |
| 40 | Effects of Peak Inspiratory Flow on Development of Ventilator-induced Lung Injury in Rabbits | Anesthesiology | 2004 | 95 |
| 41 | Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos | Development (Cambridge) | 1993 | 92 |
| 42 | MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways | Oncogene | 2011 | 91 |
| 43 | Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population | Cancer Science | 2014 | 89 |
| 44 | AKT signaling promotes derivation of embryonic germ cells from primordial germ cells | Development (Cambridge) | 2008 | 87 |
| 45 | Comparative studies of host-cell reactivation, colony forming ability and excision repair after UV irradiation of xeroderma pigmentosum, normal human and some other mammalian cells | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 1974 | 86 |
| 46 | The role of the vimentin intermediate filaments in rat 3Y1 cells elucidated by immunoelectron microscopy and computer-graphic reconstruction | Biology of the Cell | 1990 | 86 |
| 47 | Structure of the dnaA region of Pseudomonas putida: Conservation among three bacteria, Bacillus subtilis, Escherichia coli and P. putida | Molecular Genetics and Genomics | 1989 | 85 |
| 48 | Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization | Journal of Bone and Mineral Research | 1994 | 85 |
| 49 | Abnormal Expression of Mouse Mast Cell Protease 5 Gene in Cultured Mast Cells Derived From Mutant mi/mi Mice | Blood | 1997 | 82 |
| 50 | Genetic detection of lymph node micrometastases in patients with gastric carcinoma by multiple-marker reverse transcriptase-polymerase chain reaction assay | Cancer | 2001 | 81 |
