| # | Title | Journal | Year | Citations |
|---|
| 1 | Human Anti–Tumor Necrosis Factor Monoclonal Antibody (Adalimumab) in Crohn’s Disease: the CLASSIC-I Trial | Gastroenterology | 2006 | 1,523 |
| 2 | An overview of clinical decision support systems: benefits, risks, and strategies for success | Npj Digital Medicine | 2020 | 992 |
| 3 | Probiotic bacteria enhance murine and human intestinal epithelial barrier function | Gastroenterology | 2001 | 958 |
| 4 | ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications | Journal of Crohn's and Colitis | 2019 | 958 |
| 5 | Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice | Gastroenterology | 1999 | 710 |
| 6 | A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease | Gastroenterology | 2008 | 709 |
| 7 | The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults | Gastroenterology | 2016 | 671 |
| 8 | VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis | American Journal of Gastroenterology | 2005 | 659 |
| 9 | Intestinal barrier function in health and gastrointestinal disease | Neurogastroenterology and Motility | 2012 | 613 |
| 10 | Natalizumab for the Treatment of Active Crohn’s Disease: Results of the ENCORE Trial | Gastroenterology | 2007 | 586 |
| 11 | A Randomized, Placebo-Controlled Trial of Certolizumab Pegol (CDP870) for Treatment of Crohn’s Disease | Gastroenterology | 2005 | 571 |
| 12 | Liver cirrhosis | Lancet, The | 2021 | 515 |
| 13 | Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease | Gastroenterology | 2000 | 490 |
| 14 | Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid | Gastroenterology | 2015 | 470 |
| 15 | Bacterial Infections, Sepsis, and Multiorgan Failure in Cirrhosis | Seminars in Liver Disease | 2008 | 460 |
| 16 | Effect of Oral Capsule– vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection | JAMA - Journal of the American Medical Association | 2017 | 446 |
| 17 | Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management | Clinical Gastroenterology and Hepatology | 2020 | 437 |
| 18 | A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease | Gastroenterology | 1998 | 381 |
| 19 | The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy | Gastroenterology | 2016 | 373 |
| 20 | A multicenter study to define sarcopenia in patients with end‐stage liver disease | Liver Transplantation | 2017 | 343 |
| 21 | Probiotics in Critically Ill Patients | Journal of Clinical Gastroenterology | 2008 | 339 |
| 22 | DNA from probiotic bacteria modulates murine and human epithelial and immune function | Gastroenterology | 2004 | 294 |
| 23 | International consensus conference on stool banking for faecal microbiota transplantation in clinical practice | Gut | 2019 | 290 |
| 24 | A MELD-Based Model to Determine Risk of Mortality Among Patients With Acute Variceal Bleeding | Gastroenterology | 2014 | 285 |
| 25 | Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin | Clinical Gastroenterology and Hepatology | 2008 | 283 |
| 26 | Interleukin-10 Gene-Deficient Mice Develop a Primary Intestinal Permeability Defect in Response to Enteric Microflora | Inflammatory Bowel Diseases | 1999 | 259 |
| 27 | Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse | Gut | 2009 | 251 |
| 28 | ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects | Journal of Crohn's and Colitis | 2019 | 250 |
| 29 | Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma | Liver Transplantation | 2004 | 241 |
| 30 | Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: An updated meta‐analysis | Journal of Gastroenterology and Hepatology (Australia) | 2011 | 237 |
| 31 | Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD | Gut | 2017 | 237 |
| 32 | Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin | Alimentary Pharmacology and Therapeutics | 2005 | 232 |
| 33 | Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis | Hepatology | 2015 | 230 |
| 34 | Antibiotic therapy attenuates colitis in interleukin 10 gene–deficient mice | Gastroenterology | 2000 | 215 |
| 35 | Intestinal sugar transport | World Journal of Gastroenterology | 2006 | 210 |
| 36 | Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease | Gut | 2002 | 207 |
| 37 | A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis | Hepatology | 2018 | 204 |
| 38 | American Gastroenterological Association Consensus Development Conference on the Use of Biologics in the Treatment of Inflammatory Bowel Disease, June 21–23, 2006 | Gastroenterology | 2007 | 197 |
| 39 | Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome | Diabetes | 2017 | 189 |
| 40 | Patients With Cirrhosis and Denied Liver Transplants Rarely Receive Adequate Palliative Care or Appropriate Management | Clinical Gastroenterology and Hepatology | 2014 | 188 |
| 41 | Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials | Lancet, The | 2022 | 187 |
| 42 | The impact of a gluten-free diet on adults with coeliac disease: results of a national survey | Journal of Human Nutrition and Dietetics | 2006 | 185 |
| 43 | Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension | Journal of Hepatology | 2015 | 183 |
| 44 | Human gut microbiota and its relationship to health and disease | Nutrition Reviews | 2011 | 182 |
| 45 | Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection | Gut | 2019 | 182 |
| 46 | The Probiotic VSL#3 Has Anti-inflammatory Effects and Could Reduce Endoscopic Recurrence After Surgery for Crohn's Disease | Clinical Gastroenterology and Hepatology | 2015 | 181 |
| 47 | Recommendations for Probiotic Use—2011 Update | Journal of Clinical Gastroenterology | 2011 | 180 |
| 48 | Endoscopic comparison of esophageal and gastroduodenal effects of risedronate and alendronate in postmenopausal women | Gastroenterology | 2000 | 178 |
| 49 | Bioproduction of Conjugated Linoleic Acid by Probiotic Bacteria Occurs In Vitro and In Vivo in Mice | Journal of Nutrition | 2006 | 178 |
| 50 | Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo‐controlled study | Alimentary Pharmacology and Therapeutics | 2013 | 167 |
